7:["$","$L12",null,{"blok":{"_uid":"fd6fd37d-e7e0-48d1-8be3-1624f0c2d42f","Sections":[{"_uid":"99e84970-7baf-4db4-949b-4011a08e5082","Button":[{"id":"","url":"","Icon":[],"Name":"Contact Us","_uid":"35ba03d1-7d08-4c9a-8013-f29ccdb381de","Fields":[],"scroll":"contactUs","data_Id":"CTA Button - Hero Section","component":"Button"}],"Heading":"Hepatron® 35% Liquid","component":"Product-Detail-Hero","Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Hepatron® 35% Liquid is a natural, practical source of anhydrous betaine for feed mills derived from partially desugared beet molasses. Hepatron® 35% Liquid functions as both methyl a group donor and as an exceptional osmolyte. Hepatron® 35% Liquid can be beneficial for organic feed mills as a cost-effective substitute for choline chloride and methionine. Elevate your feed with Hepatron® 35% Liquid!","type":"text"}]}]},"isH1Heading":true,"Animal_Species":[{"Name":"Poultry","Icon":{"id":11769942,"alt":"Chicken","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/24x16/779f87a961/chicken.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"2"},{"Name":"Swine","Icon":{"id":11769940,"alt":"Swine","name":"","focus":"","title":"Swine","source":"","filename":"https://a.storyblok.com/f/190033/23x16/938878805c/swine.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"3"},{"Name":"Aquaculture","Icon":{"id":11769947,"alt":"Fish","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/19x16/96a9a5b85a/fish.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"4"},{"Name":"Ruminants","Icon":{"id":11769941,"alt":"Cattle","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/18x16/66dcfea614/cattle.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"1"},{"Name":"Companions","Icon":{"id":11769945,"alt":"Dog","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/20x16/e96b6234ec/dog.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"5"}],"Feed_Solutions":[{"Name":"Gut Health","Icon":{"id":11770002,"alt":"Gut Health","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/141x150/8531d58577/gut-health.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"gut-health"},{"Name":"Young Animal Nutrition","Icon":{"id":11770006,"alt":"Young Animal Nutrition","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/150x150/8c85590264/young-animal-nutrition.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"young-animal-nutrition"},{"Name":"Immune Support","Icon":{"id":11770004,"alt":"Immune Stimulation","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/179x150/690b793fce/immune-stimulation.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"immunity-support"},{"Name":"Feed Efficiency & Attraction","Icon":{"id":11769999,"alt":"Feed Efficiency","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/150x150/2b38b9a628/feed-efficiency.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Slug":"feed-efficiency-attraction"}],"Animal_Species_Title":"Animal Species","Feed_Solutions_Title":"Feed Solutions","BreadCrumbs_Current":"Hepatron® 35% Liquid"},{"Name":"Benefits","_uid":"968bf2dc-5ff5-426f-838c-3503b63355a2","Cards":[{"Heading":"Source of Methyl Groups","Description":"Methyl groups are vital for RNA and DNA synthesis, gene regulation, immune function, protein synthesis, and fatty acid metabolism. During growth and development, these pathways are highly active.","image":{"id":10956353,"alt":"Source of Methyl Groups","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/150x150/6c5dc7991f/source-of-methyl-groups.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false}},{"Heading":"Osmolyte","Description":"Osmolytes help balance water and ions in living cells, maintaining health. In the intestine, osmolytes function to help maintain intestinal integrity, especially during heat stress or diarrhea.","image":{"id":10956368,"alt":"Osmolyte","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/150x150/9a5a50f8ad/osmolyte.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false}},{"Heading":"Nutrient Sparing","Description":"Nutrient sparing ingredients perform essential processes in the body. These allow other costly, often rate-limiting, nutrients to be used to their full potential.","image":{"id":10956377,"alt":"Nutrient Sparing","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/150x150/53aab10b13/nutrient-sparing.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false}},{"Heading":"Improved Feed Palatability","Description":"Increasing feed palatability improves feed intake, especially in times of high metabolic demand. This improves growth and development, guards against metabolic disorders, and increases productivity.","image":{"id":10956356,"alt":"Improved Feed Palatability","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/150x150/85178a8b9f/improved-feed-palatability.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false}}],"Heading":"Product Benefits.","isBgGrey":false,"component":"Benefits_Career","Description":"","isCenterImage":true,"isSliderOnMobile":false},{"_uid":"3e194e04-e1d0-4a86-988b-884f25c94414","name":"Mode of Action Section","cards":[{"Heading":"Methyl-group Donor","Description":"Methyl groups are vital for RNA and DNA synthesis, gene regulation, immune function, protein synthesis, and fatty acid metabolism. During growth and development, these pathways are highly active."},{"Heading":"Osmoregulation","Description":"Functions to help regulate osmotic pressure and maintain cellular homeostasis, particularly in response to environmental stressors. In the intestine, this function helps maintain intestinal integrity."}],"image":[],"links":[],"Heading":"Modes of Action.","buttons":[],"isBgGrey":true,"component":"Section_Template","isTextLeft":false,"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Our effective range of feed additives and dietary feed supplements are specifically selected and developed to support animal health and productivity.","type":"text"}]}]},"isH1Heading":false,"Filter_Buttons":[]},{"_uid":"57fb2c91-7950-437b-8799-49c4af110e8e","Heading":"Product Specifications.","component":"Product_Specification_Section","Description":"","Availability_Text":"*This product may not be available in all markets.","list":[{"_uid":"de8d6bc3-bdc9-4e01-9f73-f1713629a089","Animals_3":"Cattle, Dairy Cattle, Beef Cattle, Calves, Goats, Kids, Sheep, Lambs, Chicken, Breeders, Broilers, Layers, Ducks, Turkeys, Fattening Turkeys, Fish, Shrimps, Sows, Piglets, Fattening Pigs, Dogs, Cats, Horses, Foals","Soluble_7":"Yes","component":"Specification","Challenges_5":"Nutrient Deficiency, Heat Stress","Heat_Stable_6":"Yes","Availability_9":"","Package_Size_8":"1000 l, Bulk","Product_Form_2":"Liquid","Animal_Category":"","Product_Group_1":"Betaine","Main_Ingredients_4":""}],"product":{"Name":"Hepatron® 35% Liquid","Type":["Betaine"],"_uid":"325b7d70-288e-42e3-a98b-a63f7946d40e","Views":"0","Ranking":"2","Soluble":true,"Benefits":["a4ba2fe7-bef5-4c1a-b58d-a875dc89bf22","a81a1cc3-a7f1-4d16-a8ee-c8be9552b0d0","5e31ea35-a733-4052-9d15-baae2b86ea95","89a19d46-6763-47ea-a11d-1a9f099bd326"],"no_index":false,"component":"product","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"Hepatron® 35% Liquid - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/4000x3000/d1132e42eb/hepatron-35.webp","og_title":"Hepatron® 35% Liquid - Biochem","description":"Hepatron® 35% Liquid is a natural, practical source of anhydrous betaine for feed mills derived from partially desugared beet molasses. ","twitter_image":"https://a.storyblok.com/f/190033/4000x3000/d1132e42eb/hepatron-35.webp","twitter_title":"Hepatron® 35% Liquid - Biochem","og_description":"Hepatron® 35% Liquid is a natural, practical source of anhydrous betaine for feed mills derived from partially desugared beet molasses. ","twitter_description":"Hepatron® 35% Liquid is a natural, practical source of anhydrous betaine for feed mills derived from partially desugared beet molasses. "},"Challenges":["Heat Stress","Nutrient Deficiency"],"Application":["875e6ce7-84f6-4a73-97d9-8b0d6f6b8232"],"Description":"$13","Heat_Stable":true,"Video_Links":[],"Availability":true,"Package_Size":["1000 L","Bulk"],"Product_Form":["Liquid"],"Display_Image":{"id":11567439,"alt":"Hepatron 35","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/4000x3000/d1132e42eb/hepatron-35.webp","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Animal_Species":["888ff53a-18a3-46b2-8333-ff560e35e5a1","fd1eeff1-3fec-434c-8cbc-39e38f966007","55d3b968-2ba6-474c-8926-7cf0e779b6e0","dcd74202-ba01-4f86-bd3f-f333607f395d","68e0ff4d-df74-4e39-88f4-db24d095692d"],"Feed_Solutions":["abc9dcbc-1d46-4635-b3a9-26b833e011c1","4d20b04c-d593-4dac-bcd3-ae4cf3e6f77c","0b70fc3f-fc3f-4201-84a5-be656f27c716","6b994c69-a560-4fc5-9942-3a00876716f2"],"canonical_link":"","Mode_of_Actions":["58fb07b8-0d60-4f4c-9cf1-510c587a5113","f3fec327-ccfc-4839-a674-cec0f47af752"],"Side_Bar_Filter":["4_1","4_2","2_1_1","2_1_3","2_2","2_3","3_1","2_1","3_2","3_3","1_1","1_2","1_3","5_1","5_2","5_3","1_1_1","1_1_2","1_1_3","1_2_1","1_3_1","2_1_2","2_3_1","5_3_1"],"Country_Specific":[],"Related_Products":[],"Product_Information":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" is a natural, practical source of betaine anhydrous for feed mills derived from partially desugared beet molasses. This unique feed ingredient offers non-toxic, stable, and GMO-free characteristics, resulting in a high-quality product that improves nutrient digestibility and enhances growth performance. ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" is perfect for inclusion into organic feeds.","type":"text","marks":[]}]},{"type":"paragraph","content":[{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" functions as a methyl group donor and provides physiological benefits through its osmoregulatory effects. As a methyl group donor, ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" plays an essential role in proper liver health and liver function, cellular replication, and detoxification reactions. It also supports the production of carnitine and kidney protection. In this function, betaine is more efficient than choline chloride.","type":"text","marks":[]}]},{"type":"paragraph","content":[{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" ","type":"text","marks":[{"type":"bold"}]},{"text":"in aquaculture feeds is an excellent attractant to increase feed acceptance and intake as well as cover-up off-flavors like those from plant material. As betaine is a natural component of common prey like snails, squid, and crustaceans, ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" ","type":"text","marks":[{"type":"bold"}]},{"text":"brings back the natural flavor of feed.","type":"text","marks":[]}]},{"type":"paragraph","content":[{"text":"Besides its role as a methyl group donor, ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" contributes to osmoregulation. Betaine accumulates in gut cells, stabilizes the water balance, and protects cells against dehydration. This support of intestinal stability and functionality results in a healthy gut mucosa, optimal nutrient intake, coccidiostat support, and drier litter.","type":"text","marks":[]}]},{"type":"paragraph","content":[{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" is especially beneficial for feed mills formulating for organic feeds and for organic farming. ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" is a cost-effective substitute for choline chloride and methionine and results in a reduction in chlorides in feed. Moreover, its function as a methyl group donor allows for reduced methionine inclusion rates and crude protein levels.","type":"text","marks":[]}]},{"type":"paragraph","content":[{"text":"Embrace the natural power of sugar beets with ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":" and provide your animals with exceptional nutrition and support for optimal performance. Elevate your feed with ","type":"text","marks":[]},{"text":"Hepatron® 35% Liquid","type":"text","marks":[{"type":"bold"}]},{"text":"!","type":"text","marks":[]}]}]},"Product_Specification":"$18","Product_Information_Images":[{"id":11939873,"alt":"Hepatron 35 Liquid","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/2caec7e482/hepatron-35.webp","copyright":"","fieldtype":"asset","meta_data":{}}]}},{"Name":"How to use Section","_uid":"a8e0c7e6-e732-4140-ae5e-63199205bcd7","Cards":[{"Heading":"In Feed","Description":"","image":{"id":10956643,"alt":"In Feed","name":"","focus":"","title":"In Feed","source":"","filename":"https://a.storyblok.com/f/190033/162x150/b769be8a76/feed-application.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false}}],"Heading":"Application Method.","isBgGrey":true,"component":"Benefits_Career","Description":"","isCenterImage":true,"isSliderOnMobile":false},{"_uid":"81a7027c-9c19-49ad-8d62-85b7ade44e18","Video":"","Images":"$1a","Content":"$1c","Heading":"Product Description.","component":"Product_Information_Section","Video_Links":"$6b"},{"id":"contactUs","Form":[{"Name":"first","_uid":"bef42218-6d72-40f4-92dd-e584743342d6","Label":"First Name","Required":true,"component":"Form_Input","Input_Type":"text","Placeholder":"Enter your first name"},{"Name":"last","_uid":"374eed14-feab-4ab2-b4e4-19229972f12a","Label":"Last Name","Required":true,"component":"Form_Input","Input_Type":"text","Placeholder":"Enter your last name"},{"Name":"email","_uid":"298944e6-a278-4e9b-b75c-d160a686e0d2","Label":"Email","Required":true,"component":"Form_Input","Input_Type":"email","Placeholder":"Enter your email"},{"Name":"mobile","_uid":"d8f8f764-8a7f-4fe4-a279-27d9a34d4011","Label":"Mobile","Required":false,"component":"Form_Input","Input_Type":"tel","Placeholder":"Enter your mobile number"},{"Name":"country","_uid":"0b465dc3-a658-4d76-a170-f2c9adc07447","Label":"Select Country","Required":true,"component":"Form_Input","Input_Type":"select","Placeholder":"Select your country"},{"Name":"message","_uid":"9bf2c3a1-1daa-42a3-b4f3-32d8f4a3311d","Label":"Message","Required":true,"component":"Form_Input","Input_Type":"text","Placeholder":"Enter your message"},{"Name":"Language","_uid":"29312ce5-e105-44f8-bb92-44582ce48f60","Label":"Select Language","Required":true,"component":"Form_Input","Input_Type":"select","Placeholder":"Select your language"}],"_uid":"23fba86a-cc79-40e3-9c6a-c15d85321505","Button":[{"Icon":[],"Name":"Submit Now","_uid":"7023fbc1-1b64-430b-b529-6a4f8f526a6e","data_Id":"ProductInquiry","component":"Button"}],"Heading":"Contact Us.","isBgGrey":false,"component":"Newsletter_Section","Description":"Connect with us! Let's discuss how we can help you achieve your goals.","isHeadingLeft":false,"Country_Selector":["Germany","Spain","Mexico","Turkey"],"Language_Selector":["EN","DE","ES"],"hasSubscribeCheckBox":true,"Newsletter_CheckBox_Text":"","Newsletter_CheckBox_Error":"","Terms_Conditions_CheckBox_Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"I have read and agree to the","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text"},{"text":"terms & conditions","type":"text","marks":[{"type":"link","attrs":{"href":"/privacy-and-policy","uuid":"a72fed2f-3d5d-4e2f-926c-1ec1447902ef","anchor":null,"target":"_self","linktype":"story"}},{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}},{"type":"underline"}]}]}]},"Terms_Conditions_CheckBox_Error":""},{"_uid":"a8ca3019-3aaf-4a91-8351-0c44ce73fbe2","Button":[{"Icon":[],"Name":"See All Products","_uid":"972940a2-3348-47e8-ac48-09eb6f78808d","data_Id":"CTA Button - Page Body","component":"Button"}],"Heading":"Related & Complimentary Products.","isBgGrey":false,"component":"Product_Section","Description":"","Product_Slider":[{"name":"BetaTrace® Manganese","created_at":"2024-09-23T11:33:58.932Z","published_at":"2025-03-27T04:38:59.359Z","updated_at":"2025-03-27T04:38:59.381Z","id":552230298,"uuid":"b178460e-bb50-4d76-88b2-021d0949dfa6","content":{"Name":"BetaTrace® Manganese","Type":["Trace Minerals"],"_uid":"571c4d8d-f93d-4bdb-b7f6-6c54a1b7ff81","Views":"0","Ranking":"1","Soluble":true,"Benefits":["836818d7-6299-4d0f-a38c-1a040308689c","61d06ed5-ca69-4c72-a5be-4a96a41ae521","0eac4a69-73b9-4d1b-b391-1dbb8c432134","11cd1108-a112-42af-b90e-1fe872d23e3e","7877074c-be10-4b45-87f7-cedab763338f","9e71df74-9831-45a9-9a79-382093623511","a4ba2fe7-bef5-4c1a-b58d-a875dc89bf22","5e31ea35-a733-4052-9d15-baae2b86ea95"],"no_index":false,"component":"product","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"BetaTrace® Manganese - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/1000x750/4e232a8f81/betatrace_mn.webp","og_title":"BetaTrace® Manganese - Biochem","description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Manganese is a unique molecule—betaine bound to manganese and designed to unlock the full nutritional potential of your feed.","twitter_image":"https://a.storyblok.com/f/190033/1000x750/4e232a8f81/betatrace_mn.webp","twitter_title":"BetaTrace® Manganese - Biochem","og_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Manganese is a unique molecule—betaine bound to manganese and designed to unlock the full nutritional potential of your feed.","twitter_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Manganese is a unique molecule—betaine bound to manganese and designed to unlock the full nutritional potential of your feed."},"Challenges":["Immune Deficiency","Lameness","Heat Stress","Eggshell Quality"],"Application":["c7feb605-b7e1-48c3-be69-447f36fb5166","875e6ce7-84f6-4a73-97d9-8b0d6f6b8232","de4ccaae-c9fa-4fbf-88c5-c2df45a19d1e"],"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Trace elements have the smallest proportion in feed, but they make all the difference! ","type":"text"},{"text":"BetaTrace® Manganese","type":"text","marks":[{"type":"bold"}]},{"text":" is a unique molecule—betaine bound to manganese and designed to unlock the full nutritional potential of your feed. Benefit from the sustainable effects of the highly bioavailable manganese and the metabolic powerhouse betaine and experience improved animal growth, immunity, and production. ","type":"text"},{"text":"BetaTrace® Manganese","type":"text","marks":[{"type":"bold"}]},{"text":" is the perfect choice for all your animals!","type":"text"}]}]},"Heat_Stable":true,"Video_Links":[],"Availability":true,"Package_Size":["25 KG","1000 KG"],"Product_Form":["Powder & Granulate"],"Display_Image":{"id":16666291,"alt":"Betatrace_Mn","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/4e232a8f81/betatrace_mn.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Mn","title":"","source":"","copyright":""},"is_external_url":false},"Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","fd1eeff1-3fec-434c-8cbc-39e38f966007","888ff53a-18a3-46b2-8333-ff560e35e5a1","55d3b968-2ba6-474c-8926-7cf0e779b6e0","68e0ff4d-df74-4e39-88f4-db24d095692d"],"Feed_Solutions":["0b70fc3f-fc3f-4201-84a5-be656f27c716","6b994c69-a560-4fc5-9942-3a00876716f2","4d20b04c-d593-4dac-bcd3-ae4cf3e6f77c","abc9dcbc-1d46-4635-b3a9-26b833e011c1"],"canonical_link":"","Mode_of_Actions":["79e5d266-68e4-470d-b2e3-7392c4bccc10","10451d25-08bd-40ac-ad22-cd70363820b9","03f06042-bcd6-4c94-9cb1-3eedc0ba51ea"],"Side_Bar_Filter":["1_1","1_2","1_3","5_3","1_1_3","1_2_1","1_3_1","5_3_1","3_2","2_1","2_2","2_3","4_1","4_2","5_1","5_2","1_1_1","1_1_2","2_1_1","2_1_3","2_3_1","3_1","3_3"],"Country_Specific":[],"Related_Products":["0c8bf8cb-53bc-4201-b4d1-1606e134792e","f5274c6a-af67-43df-825f-3edbe545141f","b178460e-bb50-4d76-88b2-021d0949dfa6","984342f5-f5a8-4a99-9ad8-7f3662405f4d"],"Product_Information":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"BetaTrace® Manganese ","type":"text","marks":[{"type":"bold"}]},{"text":"is a unique form of organic manganese with numerous advantages over inorganic forms of manganese such as manganese sulfate. The binding partner for","type":"text"},{"text":" BetaTrace® Manganese ","type":"text","marks":[{"type":"bold"}]},{"text":"is the metabolic powerhouse betaine. This means that ","type":"text"},{"text":"BetaTrace® Manganese","type":"text","marks":[{"type":"bold"}]},{"text":" not only has superior absorption and bioavailability, but also great capacity to donate essential methyl groups—perfect for high-yielding and young animals with high demands.","type":"text"}]},{"type":"paragraph","content":[{"text":"Manganese is important for healthy animals. It is an essential component of several enzyme systems and is also a component of the antioxidant system. Manganese plays an important role in growth, bone, and cartilage formation; normal neurological function; and optimal eggshell quality.","type":"text"}]},{"type":"paragraph","content":[{"text":"Despite manganese’s importance, it is often supplemented as inorganic manganese such as manganese oxide or sulfate. However, inorganic manganese is easily separated in the gut allowing for the formation of insoluble complexes with other free metals or other dietary components. This results in unabsorbed manganese being excreted in the feces, potentially contaminating the environment.","type":"text"}]},{"type":"paragraph","content":[{"text":"Organically bound manganese is manganese bound to another molecule, amino acid, or small peptide to enhance absorption. Organic manganese has greater binding strength and is better protected from antagonistic effects in the gut. The result is manganese that is better absorbed and metabolized, with a direct impact on animal health and productivity.","type":"text"}]},{"type":"paragraph","content":[{"text":"BetaTrace® Manganese","type":"text","marks":[{"type":"bold"}]},{"text":"focuses on the key challenges of modern livestock farming for higher productivity and well-being. Both betaine and manganese play a significant role in many important metabolic processes. With superior absorption over inorganic manganese,","type":"text"},{"text":"BetaTrace® Manganese","type":"text","marks":[{"type":"bold"}]},{"text":"is a perfect choice!","type":"text"}]}]},"Product_Specification":[{"_uid":"5093f96e-a991-416a-9af4-1971a940a243","Animals_3":"Cattle, Dairy Cattle, Beef Cattle, Calves, Goats, Kids, Sheep, Lambs, Chicken, Breeders, Broiler, Layers, Ducks, Turkeys, Fattening Turkeys, Sows, Piglets, Fattening Pigs, Fish, Shrimp, Dogs, Cats, Horses, Foals","Soluble_7":"Yes","component":"Specification","Challenges_5":"Immune Deficiency, Nutrient Deficiency","Heat_Stable_6":"Yes","Availability_9":"*This product may not be available in all markets. ","Package_Size_8":"25 kg, 1000 kg","Product_Form_2":"Granulate","Product_Group_1":"Trace Minerals","Main_Ingredients_4":""}],"Product_Information_Images":[{"id":16666289,"alt":"Betatrace_Zn","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/287a3a0136/betatrace_zn.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Zn","title":"","source":"","copyright":""}}]},"slug":"betatrace-manganese","full_slug":"products/betatrace-manganese","sort_by_date":null,"position":-800,"tag_list":[],"is_startpage":false,"parent_id":310901628,"meta_data":null,"group_id":"1db2805f-ecb9-4f42-8736-d8eecd19010f","first_published_at":"2024-05-29T10:57:33.519Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"products/betatrace-manganese","translated_slugs":[{"path":"products/betatrace-manganese","name":"BetaTrace® Manganese","lang":"de","published":true},{"path":"products/betatrace-manganese","name":null,"lang":"es","published":null},{"path":"products/betatrace-manganese","name":null,"lang":"pt-br","published":null}]},{"name":"BetaTrace® Zinc","created_at":"2024-09-23T11:29:42.900Z","published_at":"2025-03-13T07:29:17.391Z","updated_at":"2025-03-13T07:29:17.412Z","id":552229769,"uuid":"984342f5-f5a8-4a99-9ad8-7f3662405f4d","content":{"Name":"BetaTrace® Zinc","Type":["Trace Minerals"],"_uid":"571c4d8d-f93d-4bdb-b7f6-6c54a1b7ff81","Views":"0","Ranking":"1","Soluble":true,"Benefits":["836818d7-6299-4d0f-a38c-1a040308689c","61d06ed5-ca69-4c72-a5be-4a96a41ae521","0eac4a69-73b9-4d1b-b391-1dbb8c432134","11cd1108-a112-42af-b90e-1fe872d23e3e","7877074c-be10-4b45-87f7-cedab763338f","9e71df74-9831-45a9-9a79-382093623511","a4ba2fe7-bef5-4c1a-b58d-a875dc89bf22","5e31ea35-a733-4052-9d15-baae2b86ea95"],"no_index":false,"component":"product","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"BetaTrace® Zinc - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/1000x750/287a3a0136/betatrace_zn.webp","og_title":"BetaTrace® Zinc - Biochem","description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Zinc is a unique molecule—betaine bound to zinc and designed to unlock the full nutritional potential of your feed.","twitter_image":"https://a.storyblok.com/f/190033/1000x750/287a3a0136/betatrace_zn.webp","twitter_title":"BetaTrace® Zinc - Biochem","og_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Zinc is a unique molecule—betaine bound to zinc and designed to unlock the full nutritional potential of your feed.","twitter_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Zinc is a unique molecule—betaine bound to zinc and designed to unlock the full nutritional potential of your feed."},"Challenges":["Immune Deficiency","Lameness","Heat Stress","Eggshell Quality"],"Application":["c7feb605-b7e1-48c3-be69-447f36fb5166","875e6ce7-84f6-4a73-97d9-8b0d6f6b8232","de4ccaae-c9fa-4fbf-88c5-c2df45a19d1e"],"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Trace elements have the smallest proportion in feed, but they make all the difference! ","type":"text"},{"text":"BetaTrace® Zinc","type":"text","marks":[{"type":"bold"}]},{"text":" is a unique molecule—betaine bound to zinc and designed to unlock the full nutritional potential of your feed. Benefit from the sustainable effects of the highly bioavailable zinc and the metabolic powerhouse betaine and experience improved animal growth, immunity, and production. ","type":"text"},{"text":"BetaTrace® Zinc","type":"text","marks":[{"type":"bold"}]},{"text":" is the perfect choice for all your animals!","type":"text"}]}]},"Heat_Stable":true,"Video_Links":[],"Availability":true,"Package_Size":["25 KG","1000 KG"],"Product_Form":["Powder & Granulate"],"Display_Image":{"id":16666289,"alt":"Betatrace_Zn","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/287a3a0136/betatrace_zn.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Zn","title":"","source":"","copyright":""},"is_external_url":false},"Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","fd1eeff1-3fec-434c-8cbc-39e38f966007","888ff53a-18a3-46b2-8333-ff560e35e5a1","55d3b968-2ba6-474c-8926-7cf0e779b6e0","68e0ff4d-df74-4e39-88f4-db24d095692d"],"Feed_Solutions":["0b70fc3f-fc3f-4201-84a5-be656f27c716","6b994c69-a560-4fc5-9942-3a00876716f2","4d20b04c-d593-4dac-bcd3-ae4cf3e6f77c","abc9dcbc-1d46-4635-b3a9-26b833e011c1"],"canonical_link":"","Mode_of_Actions":["79e5d266-68e4-470d-b2e3-7392c4bccc10","10451d25-08bd-40ac-ad22-cd70363820b9","03f06042-bcd6-4c94-9cb1-3eedc0ba51ea"],"Side_Bar_Filter":["1_1","1_2","1_3","5_3","1_1_3","1_2_1","1_3_1","5_3_1","3_2","2_1","2_2","2_3","4_1","4_2","5_1","5_2","1_1_1","1_1_2","2_1_1","2_1_3","2_3_1","3_1","3_3"],"Country_Specific":[],"Related_Products":["0c8bf8cb-53bc-4201-b4d1-1606e134792e","f5274c6a-af67-43df-825f-3edbe545141f","b178460e-bb50-4d76-88b2-021d0949dfa6","984342f5-f5a8-4a99-9ad8-7f3662405f4d"],"Product_Information":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"BetaTrace® Zinc ","type":"text","marks":[{"type":"bold"}]},{"text":"is a unique form of organic zinc with numerous advantages over inorganic forms of zinc such as zinc sulfate. The binding partner for","type":"text"},{"text":" BetaTrace® Zinc ","type":"text","marks":[{"type":"bold"}]},{"text":"is the metabolic powerhouse betaine. This means that ","type":"text"},{"text":"BetaTrace® Zinc","type":"text","marks":[{"type":"bold"}]},{"text":" not only has superior absorption and bioavailability, but also great capacity to donate essential methyl groups—perfect for high-yielding and young animals with high demands.","type":"text"}]},{"type":"paragraph","content":[{"text":"Zinc is essential for healthy animals. Zinc is needed for immunity, reproduction, skin, hoof, and footpad integrity, muscle development, milk production, and eggshell quality. Moreover, the need for zinc increases during pregnancy and lactation and during stress such as extreme heat, feed changes, and relocation. Zinc is a critical component needed for cell membrane repair. As such, requirements are increased after tissue or skin damage and during wound healing.","type":"text"}]},{"type":"paragraph","content":[{"text":"Despite zinc’s importance, it is often supplemented as inorganic zinc such as zinc oxide or sulfate. However, inorganic zinc is easily separated in the gut allowing for the formation of insoluble complexes with other free metals or other dietary components. This results in unabsorbed zinc being excreted in the feces, potentially contaminating the environment.","type":"text"}]},{"type":"paragraph","content":[{"text":"Organically bound zinc is zinc bound to another molecule, amino acid, or small peptide to enhance absorption. Organic zinc has greater binding strength and is better protected from antagonistic effects in the gut. The result is zinc that is better absorbed and metabolized, with a direct impact on animal health and productivity.","type":"text"}]},{"type":"paragraph","content":[{"text":"BetaTrace® Zinc","type":"text","marks":[{"type":"bold"}]},{"text":" focuses on the key challenges of modern livestock farming for higher productivity and well-being. Both betaine and zinc play a significant role in many important metabolic processes. With superior absorption over inorganic zinc, ","type":"text"},{"text":"BetaTrace® Zinc","type":"text","marks":[{"type":"bold"}]},{"text":" is a perfect choice!","type":"text"}]}]},"Product_Specification":[{"_uid":"5093f96e-a991-416a-9af4-1971a940a243","Animals_3":"Cattle, Dairy Cattle, Beef Cattle, Calves, Goats, Kids, Sheep, Lambs, Chicken, Breeders, Broiler, Layers, Ducks, Turkeys, Fattening Turkeys, Sows, Piglets, Fattening Pigs, Fish, Shrimp, Dogs, Cats, Horses, Foals","Soluble_7":"Yes","component":"Specification","Challenges_5":"Immune Deficiency, Nutrient Deficiency","Heat_Stable_6":"Yes","Availability_9":"*This product may not be available in all markets. ","Package_Size_8":"25 kg, 1000 kg","Product_Form_2":"Granulate","Product_Group_1":"Trace Minerals","Main_Ingredients_4":""}],"Product_Information_Images":[{"id":16666289,"alt":"Betatrace_Zn","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/287a3a0136/betatrace_zn.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Zn","title":"","source":"","copyright":""}}]},"slug":"betatrace-zinc","full_slug":"products/betatrace-zinc","sort_by_date":null,"position":-800,"tag_list":[],"is_startpage":false,"parent_id":310901628,"meta_data":null,"group_id":"88fadd8f-de3d-4215-b005-c2ffd93d2b1a","first_published_at":"2024-05-29T10:57:33.519Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"products/betatrace-zinc","translated_slugs":[{"path":"products/betatrace-zinc","name":"BetaTrace® Zinc","lang":"de","published":true},{"path":"products/betatrace-zinc","name":null,"lang":"es","published":null},{"path":"products/betatrace-zinc","name":null,"lang":"pt-br","published":null}]},{"name":"BetaTrace® Copper","created_at":"2024-09-23T11:23:17.448Z","published_at":"2025-03-13T07:27:53.344Z","updated_at":"2025-03-13T07:27:53.360Z","id":552228066,"uuid":"0c8bf8cb-53bc-4201-b4d1-1606e134792e","content":{"Name":"BetaTrace® Copper","Type":["Trace Minerals"],"_uid":"571c4d8d-f93d-4bdb-b7f6-6c54a1b7ff81","Views":"0","Ranking":"1","Soluble":true,"Benefits":["836818d7-6299-4d0f-a38c-1a040308689c","61d06ed5-ca69-4c72-a5be-4a96a41ae521","0eac4a69-73b9-4d1b-b391-1dbb8c432134","11cd1108-a112-42af-b90e-1fe872d23e3e","7877074c-be10-4b45-87f7-cedab763338f","9e71df74-9831-45a9-9a79-382093623511","a4ba2fe7-bef5-4c1a-b58d-a875dc89bf22","5e31ea35-a733-4052-9d15-baae2b86ea95"],"no_index":false,"component":"product","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"BetaTrace® Copper - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/1000x750/f56afb5740/betatrace_cu.webp","og_title":"BetaTrace® Copper - Biochem","description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Copper is a unique molecule—betaine bound to copper and designed to unlock the full nutritional potential of your feed.","twitter_image":"https://a.storyblok.com/f/190033/1000x750/f56afb5740/betatrace_cu.webp","twitter_title":"BetaTrace® Copper - Biochem","og_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Copper is a unique molecule—betaine bound to copper and designed to unlock the full nutritional potential of your feed.","twitter_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Copper is a unique molecule—betaine bound to copper and designed to unlock the full nutritional potential of your feed."},"Challenges":["Immune Deficiency","Lameness","Heat Stress","Eggshell Quality"],"Application":["c7feb605-b7e1-48c3-be69-447f36fb5166","875e6ce7-84f6-4a73-97d9-8b0d6f6b8232","de4ccaae-c9fa-4fbf-88c5-c2df45a19d1e"],"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Trace elements have the smallest proportion in feed, but they make all the difference! ","type":"text"},{"text":"BetaTrace® Copper","type":"text","marks":[{"type":"bold"}]},{"text":" is a unique molecule—betaine bound to copper and designed to unlock the full nutritional potential of your feed. Benefit from the sustainable effects of the highly bioavailable copper and the metabolic powerhouse betaine and experience improved animal growth, immunity, and production. ","type":"text"},{"text":"BetaTrace® Copper","type":"text","marks":[{"type":"bold"}]},{"text":" is the perfect choice for all your animals!","type":"text"}]}]},"Heat_Stable":true,"Video_Links":[],"Availability":true,"Package_Size":["25 KG","1000 KG"],"Product_Form":["Powder & Granulate"],"Display_Image":{"id":16666290,"alt":"Betatrace_Cu","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/f56afb5740/betatrace_cu.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Cu","title":"","source":"","copyright":""},"is_external_url":false},"Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","fd1eeff1-3fec-434c-8cbc-39e38f966007","888ff53a-18a3-46b2-8333-ff560e35e5a1","55d3b968-2ba6-474c-8926-7cf0e779b6e0","68e0ff4d-df74-4e39-88f4-db24d095692d"],"Feed_Solutions":["0b70fc3f-fc3f-4201-84a5-be656f27c716","6b994c69-a560-4fc5-9942-3a00876716f2","4d20b04c-d593-4dac-bcd3-ae4cf3e6f77c"],"canonical_link":"","Mode_of_Actions":["79e5d266-68e4-470d-b2e3-7392c4bccc10","10451d25-08bd-40ac-ad22-cd70363820b9","03f06042-bcd6-4c94-9cb1-3eedc0ba51ea"],"Side_Bar_Filter":["1_1","1_2","1_3","5_3","1_1_3","1_2_1","1_3_1","5_3_1","3_2","2_1","2_2","2_3","4_1","4_2","5_1","5_2","1_1_1","1_1_2","2_1_1","2_1_3","2_3_1","3_1","3_3"],"Country_Specific":[],"Related_Products":["0c8bf8cb-53bc-4201-b4d1-1606e134792e","f5274c6a-af67-43df-825f-3edbe545141f","b178460e-bb50-4d76-88b2-021d0949dfa6","984342f5-f5a8-4a99-9ad8-7f3662405f4d"],"Product_Information":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"BetaTrace® Copper ","type":"text","marks":[{"type":"bold"}]},{"text":"is a unique form of organic copper with numerous advantages over inorganic forms of copper such as copper sulfate. The binding partner for","type":"text"},{"text":" BetaTrace® Copper ","type":"text","marks":[{"type":"bold"}]},{"text":"is the metabolic powerhouse betaine. This means that ","type":"text"},{"text":"BetaTrace® Copper","type":"text","marks":[{"type":"bold"}]},{"text":" not only has superior absorption and bioavailability, but also great capacity to donate essential methyl groups—perfect for high-yielding and young animals with high demands.","type":"text"}]},{"type":"paragraph","content":[{"text":"Copper is important for healthy animals. Copper has many physiological functions. It participates in iron metabolism, energy metabolism, and the formation of normal hair color. It is essential for body, bone, and wool growth, healthy nerve fibers, and white blood cell function. In shrimp, copper is part of the protein that transports oxygen in the blood.","type":"text"}]},{"type":"paragraph","content":[{"text":"Despite copper’s importance, it is often supplemented as inorganic copper such as copper oxide or sulfate. However, inorganic copper is easily separated in the gut allowing for the formation of insoluble complexes with other free metals or other dietary components. This results in unabsorbed copper being excreted in the feces, potentially contaminating the environment.","type":"text"}]},{"type":"paragraph","content":[{"text":"Organically bound copper is copper bound to another molecule, amino acid, or small peptide to enhance absorption. Organic copper has greater binding strength and is better protected from antagonistic effects in the gut. The result is copper that is better absorbed and metabolized, with a direct impact on animal health and productivity.","type":"text"}]},{"type":"paragraph","content":[{"text":"BetaTrace® Copper","type":"text","marks":[{"type":"bold"}]},{"text":" focuses on the key challenges of modern livestock farming for higher productivity and well-being. Both betaine and copper play a significant role in many important metabolic processes. With superior absorption over inorganic copper, ","type":"text"},{"text":"BetaTrace® Copper","type":"text","marks":[{"type":"bold"}]},{"text":" is a perfect choice!","type":"text"}]}]},"Product_Specification":[{"_uid":"5093f96e-a991-416a-9af4-1971a940a243","Animals_3":"Cattle, Dairy Cattle, Beef Cattle, Calves, Goats, Kids, Sheep, Lambs, Chicken, Breeders, Broiler, Layers, Ducks, Turkeys, Fattening Turkeys, Sows, Piglets, Fattening Pigs, Fish, Shrimp, Dogs, Cats, Horses, Foals","Soluble_7":"Yes","component":"Specification","Challenges_5":"Immune Deficiency, Nutrient Deficiency","Heat_Stable_6":"Yes","Availability_9":"*This product may not be available in all markets. ","Package_Size_8":"25 kg, 1000 kg","Product_Form_2":"Granulate","Product_Group_1":"Trace Minerals","Main_Ingredients_4":""}],"Product_Information_Images":[{"id":16666290,"alt":"Betatrace_Cu","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/f56afb5740/betatrace_cu.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Cu","title":"","source":"","copyright":""}}]},"slug":"betatrace-copper","full_slug":"products/betatrace-copper","sort_by_date":null,"position":-800,"tag_list":[],"is_startpage":false,"parent_id":310901628,"meta_data":null,"group_id":"a762a198-f521-40c2-807d-eee601f31b97","first_published_at":"2024-05-29T10:57:33.519Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"products/betatrace-copper","translated_slugs":[{"path":"products/betatrace-copper","name":"BetaTrace® Copper","lang":"de","published":true},{"path":"products/betatrace-copper","name":null,"lang":"es","published":null},{"path":"products/betatrace-copper","name":null,"lang":"pt-br","published":null}]},{"name":"BetaTrace® Iron","created_at":"2024-09-23T11:05:22.792Z","published_at":"2025-03-13T07:28:17.578Z","updated_at":"2025-03-13T07:28:17.599Z","id":552183369,"uuid":"f5274c6a-af67-43df-825f-3edbe545141f","content":{"Name":"BetaTrace® Iron","Type":["Trace Minerals"],"_uid":"571c4d8d-f93d-4bdb-b7f6-6c54a1b7ff81","Views":"0","Ranking":"1","Soluble":true,"Benefits":["836818d7-6299-4d0f-a38c-1a040308689c","61d06ed5-ca69-4c72-a5be-4a96a41ae521","0eac4a69-73b9-4d1b-b391-1dbb8c432134","11cd1108-a112-42af-b90e-1fe872d23e3e","7877074c-be10-4b45-87f7-cedab763338f","9e71df74-9831-45a9-9a79-382093623511","a4ba2fe7-bef5-4c1a-b58d-a875dc89bf22","5e31ea35-a733-4052-9d15-baae2b86ea95"],"no_index":false,"component":"product","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"BetaTrace® Iron - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/1000x750/ae5f2a2995/betatrace_fe.webp","og_title":"BetaTrace® Iron - Biochem","description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Iron is a unique molecule—betaine bound to iron and designed to unlock the full nutritional potential of your feed. ","twitter_image":"https://a.storyblok.com/f/190033/1000x750/ae5f2a2995/betatrace_fe.webp","twitter_title":"BetaTrace® Iron - Biochem","og_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Iron is a unique molecule—betaine bound to iron and designed to unlock the full nutritional potential of your feed. ","twitter_description":"Trace elements have the smallest proportion in feed, but they make all the difference! BetaTrace® Iron is a unique molecule—betaine bound to iron and designed to unlock the full nutritional potential of your feed. "},"Challenges":["Immune Deficiency","Lameness","Heat Stress","Eggshell Quality"],"Application":["c7feb605-b7e1-48c3-be69-447f36fb5166","875e6ce7-84f6-4a73-97d9-8b0d6f6b8232","de4ccaae-c9fa-4fbf-88c5-c2df45a19d1e"],"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Trace elements have the smallest proportion in feed, but they make all the difference! ","type":"text"},{"text":"BetaTrace® Iron","type":"text","marks":[{"type":"bold"}]},{"text":" is a unique molecule—betaine bound to iron and designed to unlock the full nutritional potential of your feed. Benefit from the sustainable effects of the highly bioavailable iron and the metabolic powerhouse betaine and experience improved animal growth, immunity, and production. ","type":"text"},{"text":"BetaTrace® Iron","type":"text","marks":[{"type":"bold"}]},{"text":" is the perfect choice for all your animals!","type":"text"}]}]},"Heat_Stable":true,"Video_Links":[],"Availability":true,"Package_Size":[],"Product_Form":["Powder & Granulate"],"Display_Image":{"id":16666292,"alt":"Betatrace_Fe","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/ae5f2a2995/betatrace_fe.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Fe","title":"","source":"","copyright":""},"is_external_url":false},"Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","fd1eeff1-3fec-434c-8cbc-39e38f966007","888ff53a-18a3-46b2-8333-ff560e35e5a1","55d3b968-2ba6-474c-8926-7cf0e779b6e0","68e0ff4d-df74-4e39-88f4-db24d095692d"],"Feed_Solutions":["6b994c69-a560-4fc5-9942-3a00876716f2","4d20b04c-d593-4dac-bcd3-ae4cf3e6f77c","0b70fc3f-fc3f-4201-84a5-be656f27c716"],"canonical_link":"","Mode_of_Actions":["79e5d266-68e4-470d-b2e3-7392c4bccc10","10451d25-08bd-40ac-ad22-cd70363820b9","03f06042-bcd6-4c94-9cb1-3eedc0ba51ea"],"Side_Bar_Filter":["1_1","1_2","1_3","5_3","1_1_3","1_2_1","1_3_1","5_3_1","3_2","2_1","2_2","2_3","4_1","4_2","5_1","5_2","1_1_1","1_1_2","2_1_1","2_1_3","2_3_1","3_1","3_3"],"Country_Specific":[],"Related_Products":["0c8bf8cb-53bc-4201-b4d1-1606e134792e","f5274c6a-af67-43df-825f-3edbe545141f","b178460e-bb50-4d76-88b2-021d0949dfa6","984342f5-f5a8-4a99-9ad8-7f3662405f4d"],"Product_Information":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"BetaTrace® Iron ","type":"text","marks":[{"type":"bold"}]},{"text":"is a unique form of organic iron with numerous advantages over inorganic forms of iron such as iron sulfate. The binding partner for","type":"text"},{"text":" BetaTrace® Iron ","type":"text","marks":[{"type":"bold"}]},{"text":"is the metabolic powerhouse betaine. This means that ","type":"text"},{"text":"BetaTrace® Iron","type":"text","marks":[{"type":"bold"}]},{"text":" not only has superior absorption and bioavailability, but also great capacity to donate essential methyl groups—perfect for high-yielding and young animals with high demands.","type":"text"}]},{"type":"paragraph","content":[{"text":"Iron is important for healthy animals. Its primary role is as a component of hemoglobin and myoglobin, which are key to the transport and movement of oxygen throughout the body. Iron also functions in several enzymes that are key to energy metabolism and is a component of the antioxidant system.","type":"text"}]},{"type":"paragraph","content":[{"text":"Despite iron’s importance, it is often supplemented as inorganic iron such as sulfate. However, inorganic iron is easily separated in the gut allowing for the formation of insoluble complexes with other free metals or other dietary components. This results in unabsorbed iron being excreted in the feces, potentially contaminating the environment.","type":"text"}]},{"type":"paragraph","content":[{"text":"Organically bound iron is iron bound to another molecule, amino acid, or small peptide to enhance absorption. Organic iron has greater binding strength and is better protected from antagonistic effects in the gut. The result is iron that is better absorbed and metabolized, with a direct impact on animal health and productivity.","type":"text"}]},{"type":"paragraph","content":[{"text":"BetaTrace® Iron","type":"text","marks":[{"type":"bold"}]},{"text":" focuses on the key challenges of modern livestock farming for higher productivity and well-being. Both betaine and iron play a significant role in many important metabolic processes. With superior absorption over inorganic iron, ","type":"text"},{"text":"BetaTrace® Iron","type":"text","marks":[{"type":"bold"}]},{"text":" is a perfect choice!","type":"text"}]}]},"Product_Specification":[{"_uid":"5093f96e-a991-416a-9af4-1971a940a243","Animals_3":"Cattle, Dairy Cattle, Beef Cattle, Calves, Goats, Kids, Sheep, Lambs, Chicken, Breeders, Broiler, Layers, Ducks, Turkeys, Fattening Turkeys, Sows, Piglets, Fattening Pigs, Fish, Shrimp, Dogs, Cats, Horses, Foals","Soluble_7":"Yes","component":"Specification","Challenges_5":"Immune Deficiency, Nutrient Deficiency","Heat_Stable_6":"Yes","Availability_9":"*This product may not be available in all markets. ","Package_Size_8":"25 kg, 1000 kg","Product_Form_2":"Granulate","Product_Group_1":"Trace Minerals","Main_Ingredients_4":""}],"Product_Information_Images":[{"id":16666292,"alt":"Betatrace_Fe","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/ae5f2a2995/betatrace_fe.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Betatrace_Fe","title":"","source":"","copyright":""}}]},"slug":"betatrace-iron","full_slug":"products/betatrace-iron","sort_by_date":null,"position":-800,"tag_list":[],"is_startpage":false,"parent_id":310901628,"meta_data":null,"group_id":"51fb2285-a768-4fd3-8bbd-015381666ff7","first_published_at":"2024-05-29T10:57:33.519Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"products/betatrace-iron","translated_slugs":[{"path":"products/betatrace-iron","name":"BetaTrace® Iron","lang":"de","published":true},{"path":"products/betatrace-iron","name":null,"lang":"es","published":null},{"path":"products/betatrace-iron","name":null,"lang":"pt-br","published":null}]},{"name":"Colo-Ig®","created_at":"2024-03-25T09:41:21.544Z","published_at":"2025-03-13T09:26:21.784Z","updated_at":"2025-03-13T09:26:21.802Z","id":466704947,"uuid":"55285c2e-0a0e-4204-a4e7-feb72f52e748","content":{"Name":"Colo-Ig®","Type":["Dietary Feed Supplement"],"_uid":"571c4d8d-f93d-4bdb-b7f6-6c54a1b7ff81","Views":"0","Ranking":"1","Soluble":true,"Benefits":["efd631a3-415f-4975-a40a-2e3fdeedce98","c98ab461-f760-4797-b311-318bea0a5e0d","3fea5af0-b5d6-4d6e-893a-14cfde7e63a6","720ca160-8bb1-418b-823f-665b6e31e792"],"no_index":false,"component":"product","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"Colo-Ig® - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/1000x750/9ec2d54f31/colo-ig-isr-20kg.webp","og_title":"Colo-Ig® - Biochem","description":"Colo-Ig® is a powerful immune support formula for newborn animals. It combines high levels of bovine colostrum and an effective prebiotic in a palatable product that improves passive immunity in newborns.","twitter_image":"https://a.storyblok.com/f/190033/1000x750/9ec2d54f31/colo-ig-isr-20kg.webp","twitter_title":"Colo-Ig® - Biochem","og_description":"Colo-Ig® is a powerful immune support formula for newborn animals. It combines high levels of bovine colostrum and an effective prebiotic in a palatable product that improves passive immunity in newborns.","twitter_description":"Colo-Ig® is a powerful immune support formula for newborn animals. It combines high levels of bovine colostrum and an effective prebiotic in a palatable product that improves passive immunity in newborns."},"Challenges":["Nutrient Deficiency","Immune Deficiency"],"Application":["de4ccaae-c9fa-4fbf-88c5-c2df45a19d1e","c7feb605-b7e1-48c3-be69-447f36fb5166"],"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Colo-Ig® ","type":"text","marks":[{"type":"bold"}]},{"text":"is a powerful immune support formula for newborn animals. It combines high levels of bovine colostrum and an effective prebiotic in a palatable product that improves passive immunity in newborns. Don't jeopardize your newborn's future. Colo-Ig® gives your newborns the immune support they need to thrive.","type":"text"}]}]},"Heat_Stable":false,"Video_Links":[],"Availability":true,"Package_Size":["360 g","1440 g"],"Product_Form":["Powder & Granulate"],"Display_Image":{"id":16058024,"alt":"Colo-IG","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/9ec2d54f31/colo-ig-isr-20kg.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Colo-IG","title":"","source":"","copyright":""},"is_external_url":false},"Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","68e0ff4d-df74-4e39-88f4-db24d095692d","fd1eeff1-3fec-434c-8cbc-39e38f966007"],"Feed_Solutions":["0b70fc3f-fc3f-4201-84a5-be656f27c716","4d20b04c-d593-4dac-bcd3-ae4cf3e6f77c"],"canonical_link":"","Mode_of_Actions":["2324d93f-d3ad-40b4-b56d-1d9d00a776b2","1528951f-864b-475a-a3bd-6d5f5367270c","aa945c3b-ad1a-4cec-9cfa-a026a9f80d91","c2b4ace8-9f29-43e8-a108-238dc077d436"],"Side_Bar_Filter":["1_1","1_2","1_3","5_3","1_1_3","1_2_1","1_3_1","5_3_1","3_2"],"Country_Specific":[],"Related_Products":[],"Product_Information":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The first days of life are critical for newborn animals. They need an adequate supply of high-quality colostrum to ensure a healthy life. While farm management and colostrum quality are critical factors, they can sometimes be difficult to control or improve. This can result in increased disease incidence, mortality, and reduced growth. In these situations, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Colo-Ig®","type":"text","marks":[{"type":"bold"}]},{"text":" is a reliable solution for improving colostrum supply and providing optimal support for young animals.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Colo-Ig®","type":"text","marks":[{"type":"bold"}]},{"text":" is a potent immunity support formula for newborn animals. It contains a high level of bovine colostrum—39 % immunoglobulin content on a protein basis. This makes ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Colo-Ig®","type":"text","marks":[{"type":"bold"}]},{"text":" a rich source of active immunoglobulins, growth factors, and bioactive compounds. This critical ingredient promotes survival, growth, and ongoing health in young animals through passive immunity.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"In addition to bovine colostrum, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Colo-Ig®","type":"text","marks":[{"type":"bold"}]},{"text":" contains a prebiotic that can bind pathogenic bacteria. Moreover, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Colo-Ig","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"®","type":"text","marks":[{"type":"bold"}]},{"text":" is highly palatable and very well accepted. In this, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Colo-Ig","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"®","type":"text","marks":[{"type":"bold"}]},{"text":" both protects and supports newborn animals.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"By supplementing the natural content of colostrum or replacing maternal colostrum entirely, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Colo-Ig","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"®","type":"text","marks":[{"type":"bold"}]},{"text":" effectively improves newborn immunity, reduces the risk of passive immune transfer failure, and provides a solid foundation for a healthy life.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Don’t let the challenges of colostrum supply compromise the future of your animals. ","type":"text"},{"text":"Colo-Ig® ","type":"text","marks":[{"type":"bold"}]},{"text":"gives your newborn animals the immunity they need to thrive.","type":"text"}]}]},"Product_Specification":[{"_uid":"5093f96e-a991-416a-9af4-1971a940a243","Animals_3":"Calves, Lambs, Kids, Piglets, Foals","Soluble_7":"Yes","component":"Specification","Challenges_5":"Immune Deficiency, Nutrient Deficiency","Heat_Stable_6":"","Availability_9":"*This product may not be available in all markets. ","Package_Size_8":"360 g, 1440 g","Product_Form_2":"Powder","Product_Group_1":"Dietary Feed Supplements","Main_Ingredients_4":""}],"Product_Information_Images":[{"id":16058024,"alt":"Colo-IG","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1000x750/9ec2d54f31/colo-ig-isr-20kg.webp","copyright":"","fieldtype":"asset","meta_data":{"alt":"Colo-IG","title":"","source":"","copyright":""}}]},"slug":"colo-ig","full_slug":"products/colo-ig","sort_by_date":null,"position":-800,"tag_list":[],"is_startpage":false,"parent_id":310901628,"meta_data":null,"group_id":"f2aa58ed-dc2e-471f-b1bc-c8a4e721673b","first_published_at":"2024-05-29T10:57:33.519Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"products/colo-ig","translated_slugs":[{"path":"products/colo-ig","name":"Colo-Ig","lang":"de","published":true},{"path":"products/colo-ig","name":null,"lang":"es","published":null},{"path":"products/colo-ig","name":null,"lang":"pt-br","published":null}]}],"Icons":{"dcd74202-ba01-4f86-bd3f-f333607f395d":{"id":11769941,"alt":"Cattle","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/18x16/66dcfea614/cattle.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"888ff53a-18a3-46b2-8333-ff560e35e5a1":{"id":11769942,"alt":"Chicken","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/24x16/779f87a961/chicken.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"fd1eeff1-3fec-434c-8cbc-39e38f966007":{"id":11769940,"alt":"Swine","name":"","focus":"","title":"Swine","source":"","filename":"https://a.storyblok.com/f/190033/23x16/938878805c/swine.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"55d3b968-2ba6-474c-8926-7cf0e779b6e0":{"id":11769947,"alt":"Fish","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/19x16/96a9a5b85a/fish.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"68e0ff4d-df74-4e39-88f4-db24d095692d":{"id":11769945,"alt":"Dog","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/20x16/e96b6234ec/dog.svg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false}},"country_code":"US"},{"_uid":"f87235a2-0dd1-4db4-9727-de6dbd2c4b6a","Button":[{"Icon":[],"Name":"See All Articles","_uid":"5748af13-3c59-48d0-ac06-a2f29ce0d56a","data_Id":"CTA Button - Page Body","component":"Button"}],"Heading":"Related Articles.","Articles":[{"name":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health.","created_at":"2024-03-04T08:51:28.690Z","published_at":"2025-01-29T09:24:45.948Z","updated_at":"2025-01-29T09:24:45.990Z","id":454588824,"uuid":"3dfe74ec-e595-4dd0-9736-4026aa169522","content":{"Tags":[{"_uid":"b784cf3c-461c-44af-a698-b091126fa3c3","Products":["0624700d-72ab-4012-8013-8785f081fbce","8ae1a0c1-a663-4df1-8a09-90307f34cf67","c616d010-1662-4b95-a5fd-54cc969abda7","a87420ff-9300-4f79-89c7-bb08456a496b","bded2ce6-9dee-4c9d-bbeb-ce111ae2c0fb"],"_editable":"","component":"Tags","Animal_Species":["888ff53a-18a3-46b2-8333-ff560e35e5a1"],"Feed_Solutions":["fcc755b6-e358-48cd-aa0c-0ae722252c04","00925c7f-584a-4ca8-9180-967d87cf7261","6b994c69-a560-4fc5-9942-3a00876716f2","abc9dcbc-1d46-4635-b3a9-26b833e011c1"]}],"_uid":"7a18c452-fcbc-470f-9a3c-467b15c5895a","Image":{"id":15021714,"alt":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health.","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/1200x800/9124cede9e/conquering-coccidia-betaine-s-role-in-protecting-poultry-health.png","copyright":"","fieldtype":"asset","meta_data":{"alt":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health.","title":"","source":"","copyright":""},"is_external_url":false},"Title":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health.","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":"language-html"},"content":[{"text":"

","type":"text"}]},{"type":"horizontal_rule"},{"type":"heading","attrs":{"level":6},"content":[{"text":"Key Takeaways:","type":"text","marks":[{"type":"bold"}]}]},{"type":"bullet_list","content":[{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"Coccidiosis is a widespread and costly parasitic disease in poultry, damaging the gut and impacting growth and production.","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"Traditional control methods like medication and vaccination have downsides, including potential drug resistance and physiologic stress.","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"Betaine, a feed additive, offers a promising approach to managing the effects of coccidiostats and vaccination.","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"Betaine works by protecting intestinal cells, improving nutrient absorption, and supporting methylation, a vital cellular process.","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"Overall, betaine emerges as a powerful tool for poultry producers seeking to improve bird health, performance, and profitability.","type":"text"}]}]}]},{"type":"horizontal_rule"},{"type":"paragraph","content":[{"text":"Some 3.5 billion years ago, in the oceans of a planet very different from the one we see today, a simple, single-celled organism emerged that would eventually set the stage for all that followed. The exact evolutionary path from the prokaryotic cyanobacteria to the eukaryotic cell is lost to time, but what remains is the diversity of eukaryotic life as we know it. This includes the diverse and microscopic world of unicellular eukaryotic protozoa.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Tiny Troublemakers.","type":"text","marks":[{"type":"bold"}]}]},{"type":"paragraph","content":[{"text":"Protozoa are a diverse group of single-celled, microscopic organisms found in a wide variety of habitats. These microscopic organisms play essential roles in various ecosystems, including breaking down and recycling organic matter and helping to maintain soil fertility. However, some protozoa act as predators, consuming bacteria, algae, and other microscopic organisms. While most protozoa are harmless, some species cause parasitic infections.","type":"text"}]},{"type":"paragraph","content":[{"text":"The intracellular, parasitic protozoa responsible for disease in many farm animals belongs to the genus ","type":"text"},{"text":"Eimeria","type":"text","marks":[{"type":"italic"}]},{"text":". These protozoa, also known as coccidia, cause infectious diseases of the gastrointestinal tract. Several ","type":"text"},{"text":"Eimeria","type":"text","marks":[{"type":"italic"}]},{"text":" spp. are known to cause disease in poultry (Figure 1). The pathogenicity of coccidiosis is influenced by genetics, nutritional factors, concurrent diseases, age, and species of coccidium.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":14446504,"alt":"Figure 1: E. acervulina is the most common cause of infection","src":"https://a.storyblok.com/f/190033/1440x768/079b2d5445/figure-1-conquering-coccidia-betaine-s-role-in-protecting-poultry-health.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: E. acervulina is the most common cause of infection","title":"","source":"","copyright":""}}},{"text":"Figure 1: E. acervulina is the most common cause of infection and produces lesions in the upper half of the small intestine. E. necatrix produces major lesions in the proximal and mid portions of the small intestine. E. brunetti is found in the lower small intestine, rectum, ceca, and cloaca. E. maxima develops in the small intestine. E. tenella infections are found only in the ceca.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Eimeria ","type":"text","marks":[{"type":"italic"}]},{"text":"are almost universally present in poultry farms. It is estimated that approximately 90 % of reared poultry are infected. Birds recovering from severe infections may never return to full growth or production levels and subclinical coccidiosis is a major cause of economic loss.","type":"text"}]},{"type":"paragraph","content":[{"text":"Coccidial infection results in damage to intestinal cells, diarrhea, osmotic stress in the intestine, and, consequently, malabsorption of nutrients. In addition, apparently mild, subclinical infections can lead to secondary infections, particularly with ","type":"text"},{"text":"Clostridium","type":"text","marks":[{"type":"italic"}]},{"text":" spp., resulting in necrotic enteritis.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Controlling Coccidia.","type":"text","marks":[{"type":"bold"}]}]},{"type":"paragraph","content":[{"text":"Practical management methods cannot completely prevent coccidial infection. However, management options to reduce exposure include an all-in-all-out rearing cycle in which housing is thoroughly cleaned and disinfected between cycles. Another strategy is to use anticoccidials with or without live vaccination.","type":"text"}]},{"type":"paragraph","content":[{"text":"In broilers, anticoccidials are given in the feed to prevent disease and economic losses are often associated with a subacute infection. However, continuous use of one type of coccidiostat promotes drug resistance. This has led to the introduction of a rotation system for coccidiostats but can also lead to cross-resistance.","type":"text"}]},{"type":"paragraph","content":[{"text":"There are two main categories of coccidiostats: synthetic coccidiostats and naturally occurring polyether ionophores. Ionophore coccidiostats work by complexing with various ions, usually sodium, potassium, and calcium, and transporting them across the lipid membrane.","type":"text"}]},{"type":"paragraph","content":[{"text":"This alters the osmotic and electrochemical balance of coccidia. However, these effects are not limited to the eukaryotic protozoa—ionophores can also affect eukaryotic intestinal cells. Ultimately, this ionic and osmotic imbalance in the host can result in decreased feed intake and nutrient absorption.","type":"text"}]},{"type":"paragraph","content":[{"text":"Coccidiostats are not used in laying hens because these compounds can build up in the eggs. Instead, layer pullets are often vaccinated with live vaccines to increase the animals’ own defense mechanisms. This is the basis of a vaccination strategy—a challenge with low levels of ","type":"text"},{"text":"Eimeria","type":"text","marks":[{"type":"italic"}]},{"text":" that stimulates an immune response. This means that these birds will be exposed to the effects of a subclinical infection during this time.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Betaine: A Multi-Talented Molecule.","type":"text","marks":[{"type":"bold"}]}]},{"type":"paragraph","content":[{"text":"Betaine is a general term for the trimethyl derivative of the amino acid glycine. It is found in many plants and animals as a bipolar molecule—this is called betaine anhydrous. Betaine is a strong methyl donor and can compensate for a lack of dietary methyl groups or during periods of increased demand. The importance of methyl groups cannot be overstated. Animals that are under stress—any stress—but especially immune challenges and tissue repair require a larger supply of dietary methyl groups.","type":"text"}]},{"type":"paragraph","content":[{"text":"Betaine’s bipolar structure makes it one of nature’s most powerful organic osmolytes. Osmolytes are important in dehydration conditions because they reduce water loss against an osmotic gradient. Betaine accumulates in both healthy and stressed intestinal cells and helps maintain balance during osmotic challenges, whether from feeding, the environment, coccidiostat use, or coccidiosis (Figure 2).","type":"text"}]},{"type":"paragraph","content":[{"text":" ","type":"text"},{"type":"image","attrs":{"id":14446503,"alt":"Figure 2: During a coccidia challenge, betaine levels accumulate","src":"https://a.storyblok.com/f/190033/1440x800/ad23d59ddf/figure-2-conquering-coccidia-betaine-s-role-in-protecting-poultry-health.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: During a coccidia challenge, betaine levels accumulate","title":"","source":"","copyright":""}}},{"text":"Figure 2: During a coccidia challenge, betaine levels accumulate in challenged tissues in greater amounts compared to unchallenged tissue (control). Increased levels of betaine can help stabilize the intestinal epithelium, maintaining function during coccidiosis. Kettunen H, et al. Dietary betaine accumulates in the liver and intestinal tissue and stabilizes the intestinal epithelial structure in healthy and coccidia-infected broiler chicks. Comp Biochem Physiol A Mol Integr Physiol. 2001 Nov;130(4):759-69.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Supporting intestinal osmoregulation helps maintain efficient nutrient absorption and reduces energy loss for ion pump activity. The accumulation of betaine may have a stabilizing effect on the intestinal epithelium and preserve cell function. In fact, cell regeneration and preservation of normal cell function is key to maintaining health and performance in the face of subclinical coccidiosis—whether caused by vaccination or limited coccidiostat efficacy.","type":"text"}]},{"type":"paragraph","content":[{"text":"Extensive research has demonstrated the beneficial effects of high levels of anhydrous betaine on chicken health during coccidial infection. This knowledge could be extended to vaccinated flocks, as the vaccine induces a controlled infection. Whether betaine can strengthen the immune reaction induced by vaccination requires further study, however.","type":"text"}]},{"type":"paragraph","content":[{"text":"Dealing with the challenges posed by parasitic protozoa will require the optimal application of all available tools. This is the only way to limit the economic damage and ensure productive poultry farming. Using anhydrous betaine is an excellent method for ensuring successful countermeasures.","type":"text"}]}]},"_uid":"23c33d84-dcdf-4be9-b03e-a9b4172b1f6e","noSpace":true,"_editable":"","component":"General_Text_Section"}],"no_index":false,"_editable":"","component":"article","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/1200x800/9124cede9e/conquering-coccidia-betaine-s-role-in-protecting-poultry-health.png","og_title":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health - Biochem","description":"Tiny, single-celled creatures may sound harmless, but they cause big problems for poultry farmers. Even our current control measures can cause a drop in performance. ","twitter_image":"https://a.storyblok.com/f/190033/1200x800/9124cede9e/conquering-coccidia-betaine-s-role-in-protecting-poultry-health.png","twitter_title":"Conquering Coccidia: Betaine's Role in Protecting Poultry Health - Biochem","og_description":"Tiny, single-celled creatures may sound harmless, but they cause big problems for poultry farmers. Even our current control measures can cause a drop in performance. ","twitter_description":"Tiny, single-celled creatures may sound harmless, but they cause big problems for poultry farmers. Even our current control measures can cause a drop in performance. "},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Tiny, single-celled creatures may sound harmless, but they cause big problems for poultry farmers. Even our current control measures can cause a drop in performance. But there’s hope! Learn about the science behind betaine and how this powerful tool can help your poultry operation. Read on to unlock the secrets to healthy, thriving poultry!","type":"text"}]}]},"Search_Tags":[],"Published_on":"2024-03-27 00:00","canonical_link":""},"slug":"conquering-coccidia-betaine-s-role-in-protecting-poultry-health","full_slug":"news/articles/conquering-coccidia-betaine-s-role-in-protecting-poultry-health","sort_by_date":null,"position":-10,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"aa2ec45e-6337-4b92-9207-29a3f6249e83","first_published_at":"2023-10-18T09:20:54.031Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/conquering-coccidia-betaine-s-role-in-protecting-poultry-health","translated_slugs":[{"path":"news/articles/kokzidien-zu-besiegen:-die-rolle-von-betain-beim-schutz-der-gefluegelgesundheit","name":"Kokzidien zu besiegen: Die Rolle von Betain beim Schutz der Geflügelgesundheit.","lang":"de","published":true},{"path":"news/articles/la-conquista-de-los-coccidios:-el-papel-de-la-betaina-en-la-proteccion-de-la-salud-de-las-aves","name":"La conquista de los coccidios: el papel de la betaína en la protección de la salud de las aves.","lang":"es","published":true},{"path":"news/articles/combatendo-a-coccidia:-o-papel-da-betaina-na-protecao-da-saude-das-aves","name":"Combatendo a coccidia: o papel da betaína na proteção da saúde das aves.","lang":"pt-br","published":true}]},{"name":"Betaine – an often underestimated feed additive","created_at":"2023-09-28T13:03:26.374Z","published_at":"2025-03-28T12:49:22.151Z","updated_at":"2025-03-28T12:49:22.190Z","id":378249202,"uuid":"45298973-4f3a-4c07-a74b-676337d20c37","content":{"Tags":[{"_uid":"09402056-1b8a-4533-907d-892a2d090278","Products":["0624700d-72ab-4012-8013-8785f081fbce","8ae1a0c1-a663-4df1-8a09-90307f34cf67","c616d010-1662-4b95-a5fd-54cc969abda7","a87420ff-9300-4f79-89c7-bb08456a496b","bded2ce6-9dee-4c9d-bbeb-ce111ae2c0fb"],"component":"Tags","Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","888ff53a-18a3-46b2-8333-ff560e35e5a1","fd1eeff1-3fec-434c-8cbc-39e38f966007","55d3b968-2ba6-474c-8926-7cf0e779b6e0"],"Feed_Solutions":["abc9dcbc-1d46-4635-b3a9-26b833e011c1"]}],"Time":"10 min read","_uid":"b44837fc-8f41-44f4-a88f-f047b6431aba","Image":{"id":12056954,"alt":"Betaine—An Often Underestimated Feed Additive","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/6000x4000/10a60203c0/betaine-feed-additive.jpeg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Title":"Betaine – An Often Underestimated Feed Additive.","Author":"Biochem Team","Content":{"type":"doc","content":[{"type":"heading","attrs":{"level":1},"content":[{"text":"Oral rehydration in calves","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"Approximately 25–40% of the estimated 264 million calves born each year will be replacements for dairy cows that are removed from the herd. The current crop of female calves will become tomorrow's herd. The stakes cannot be higher for the outlook of the dairy farm—rearing healthy, productive cows are crucial to future success. However, the path to healthy calves is paved with obstacles ranging from failure of passive transfer to a multitude of infectious diseases.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Today, as throughout history, diarrhea poses a major threat to the health of a calf in the first weeks of life. A study of on-farm mortality in the UK showed that between 2011 and 2018, 25% of all deaths occurred in cattle under 3 months of age [1]. In fact, diarrhea in calves is the most economically significant disease on a dairy farm. In a 2020 survey, 81% of UK farmers had seen diarrhea in calves during the previous 12 months and 50% had lost animals to the disease over the same period. Another UK-based study has shown that diarrhea is the main cause of mortality in calves younger than two months [2].","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Many causes - one result","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"Diarrhea in calves is not a single disease. Rather, it is a manifestation of the many infectious and non-infectious causes associated with it. From the moment of calving, a newborn calf is exposed to numerous pathogens—bacteria, viruses, parasites, protozoa—all of which harm the intestinal tract and cause diarrhea. The most common bacteria responsible for diarrhea are E. coli, Salmonella, and Clostridium perfringens; viral and protozoal causes include rotavirus, coronavirus, bovine viral diarrhea virus, cryptosporidium, and coccidia.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Non-infectious causes of calf diarrhea include inadequate nutrition, unsanitary pens, overcrowding, and inadequate colostrum intake. Colostrum intake is crucial for passive immunity and the development of a functioning immune system. Lack of colostrum feeding increases the risk of various infections and causes a higher sensitivity to environmental pathogens. Ensuring sufficient colostrum intake is vital for future health. A calf should drink at least 3–4 liters of good-quality colostrum within the first four hours of life.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Although there are several forms of diarrhea, the secretory and osmotic forms are common among calves, and because of the numerous causes, a calf may often have both forms simultaneously. Secretory diarrhea involves toxins binding to intestinal cells, which allows fluid to move into the intestinal lumen. A common cause of this type of diarrhea is E. coli. Osmotic diarrhea results from a disruption of intestinal structures leading to unabsorbed nutrients, thereby creating an osmotic gradient, pulling fluid into the lumen.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Regardless of the form and the cause, the clinical signs of diarrhea are similar. Most noted is a decreased appetite and fluid intake, fever (usually over 40°C), and a weak appearance with sunken eyes. A severe case may present lying down with a low body temperature (cold to the touch). The fecal consistency may appear differently depending on the severity, alternating between greasy and fluid. Affected calves also show an increased frequency of defecation.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Metabolic acidosis - the next phase","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"In calves, metabolic acidosis is a common result of diarrhea-induced dehydration. Without treatment, metabolic acidosis is a prime factor in the death of many of these calves. Early and intensive oral electrolyte therapy at the onset of diarrhea in calves is critical to replenish fluids and correct metabolic acidosis. Therapy should be started as soon as possible regardless of whether evidence of dehydration is seen. The clinical signs of dehydration are not obvious until the calf has lost at least 6% of its body weight in fluid (figure 1). The course of therapy depends on the severity of symptoms. Calves still able to stand and suckle can often be treated with oral rehydration solutions alone to avoid continued fluid losses and restore extracellular cell fluid volume. If there are signs of systemic illness, a veterinarian should be consulted for additional therapies such as anti-inflammatories or intravenous fluids.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"type":"image","attrs":{"id":9273987,"alt":"","src":"https://a.storyblok.com/f/190033/1220x422/352e310604/3-1.png","title":"","source":"","copyright":"","meta_data":"[object Object]"}},{"text":"Keep calves eating!","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"Calves must eat. A sufficient energy intake is essential to maintain the calf's defense against infections while continuing to grow and develop. Calves have large energy requirements and little energy reserves. Since electrolyte solutions do not meet calf energy requirements; milk should not be withheld. Although feeding milk may increase fecal volume, it also provides a critical energy supply and may promote gut healing. Additionally, free access to drinking water should be provided.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Rehydration solutions are not all the same","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"“They are all the same to me!” This is a common thought among farmers when thinking about rehydration solutions for calves. With so many products available, it can be difficult to choose. However, selecting an oral rehydration solution is important. It should be effective and easily added to the daily milk ration. It should also meet the goals of oral rehydration therapy, such as the correction of dehydration through normalization of the extracellular fluid volume, provision of additional energy, supply of a buffer to prevent or correct metabolic acidosis and increase sodium and water absorption from the intestines.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"The alkalizing ability of an oral rehydration solution is dependent on the alkalizing agent. Alkalizing agents, more commonly known as buffering agents, are used to counteract acidosis. Oral electrolyte solutions have traditionally contained sodium bicarbonate because it has been shown to be highly effective. However, bicarbonate has several disadvantages. High concentrations of bicarbonate alkalize the abomasum, which interferes with abomasal milk clotting. The use of bicarbonate in rehydrating solutions could lead to a higher number of coliform bacteria that reach the small intestine, thus increasing the severity, duration, and mortality risk.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Other commonly used alkalizing agents include acetate and propionate—both with a similar alkalizing ability to bicarbonate. However, these agents offer additional benefits that bicarbonate does not. Unlike bicarbonate, acetate and propionate exert their alkalizing effects after they are absorbed and metabolized. These alkalizing agents help facilitate sodium and water absorption, produce energy when metabolized, and do not alkalinize the abomasum or interfere with milk clotting (figure 2). The administration of oral rehydration solutions containing acetate or propionate in milk or milk replacer have shown to be beneficial. Calves that have been fed with milk recover quicker and perform better than those that are taken off milk.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"type":"image","attrs":{"id":9273989,"alt":"","src":"https://a.storyblok.com/f/190033/1220x423/ceaa6c052b/3-2.png","title":"","source":"","copyright":"","meta_data":"[object Object]"}},{"text":"Combating the negative impact of diarrhea","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"A large amount of sodium and potassium are lost when a calf has diarrhea. This can result in a lowering of blood pH (metabolic acidosis), which cannot be corrected without intervention. An oral rehydration solution must be capable of efficiently buffering (counteracting) the low blood pH. The efficiency of the buffering capacity of an oral rehydration solution is defined by the strong ion difference (SID value). For moderate acidosis, oral rehydration solutions with a high SID formulation can help—an effective oral rehydrating solution should have a SID value between 60 and 80.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Calves with diarrhea not only have a reduced ability to absorb nutrients. They also have an increased demand for energy for immune function and intestinal epithelium repair. Increasing sodium absorption is one of the functions of an oral rehydration solution and cannot be achieved without an energy source. Therefore, oral rehydration solutions should provide an energy source—often in the form of sucrose or glucose.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Formulated with sodium propionate, betaine, zinc, and glucose, Prolyt Pack® Extra meets all the requirements of an effective oral rehydrating solution. Prolyt Pack® Extra has a SID value of 79—a highly effective buffer. The propionate in Prolyt Pack® Extra serves several functions. As an alkalizing agent, propionate does not alter the pH in the abomasum, which means there is no interference with milk clotting. Propionate also enhances sodium absorption in the small intestine and can be a source of energy for the calf.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Betaine is included in the formula to function as an osmolyte to improve cellular hydration. When betaine is taken up by the cells, they can maintain water volume without having to increase ion levels thus reducing ion pump use during hyperosmotic stress. The result is that less energy is needed to maintain the osmotic balance. Prolyt Pack® Extra also contains organically bound zinc to regenerate damaged intestinal epithelium and improve intestinal barrier function, helping the calf quickly return to performance levels.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Prolyt Pack® Extra","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]},{"text":" is easily added to the milk or milk replacer","type":"text"},{"type":"hard_break"},{"text":"- act early to restore your calf's water balance!","type":"text"}]},{"type":"paragraph","content":[{"text":"Hyde, R.M., et al., Quantitative analysis of calf mortality in Great Britain. Journal of Dairy Science, 2020. 103(3): p. 2615-2623.","type":"text"},{"type":"hard_break"},{"text":"Johnson, K.F., et al., Prospective cohort study to assess rates of contagious disease in pre‐weaned UK dairy heifers: management practices, passive transfer of immunity and associated calf health. Veterinary Record Open, 2017. 4(1): p. e000226.","type":"text"}]}]},"Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Betaine (trimethyglycine) is typically used as an alternative methyl group donor to replace choline chloride. The possibility to reduce methionine is additionally discussed and betaine acts as a strong osmolyte to support intestinal osmoregulation. To understand the full potential of betaine, a closer look into the different levels of digestion and metabolism might help:","type":"text"}]},{"type":"bullet_list","content":[{"type":"list_item","content":[{"type":"paragraph","content":[{"text":" On intestinal level, betaine supports enterocytes in their osmoregulation to save energy and ensure nutrient absorption as well as water and mineral balance in stress situations","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":" On metabolic level, betaine improves the availability of methyl groups to eliminate limitations in the transmethylation process and maximize the responsiveness of animals to any kind of stress","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":" On nutritional level, betaine increases the glycine supply to safeguard carcass quality and avoid growth restrictions caused by low protein diets limiting the glycine availability","type":"text"}]}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Different sources and forms of betaine available on the market.","type":"text"}]},{"type":"paragraph","content":[{"text":"Betaine was first obtained in sugar beets and this source still plays an important role in the market. It is the only source of betaine allowed in organic feed production. Natural betaine opens a great opportunity to improve the nutritional value of organic feed, as many synthetic feed additives cannot be used. It is available as a liquid and as a crystalline product. Betaine, derived from sugar beets, has a lower risk of contamination compared to synthetic products. This makes its use interesting for all feed producers, especially considering its positive image as a natural product.","type":"text"}]},{"type":"paragraph","content":[{"text":"In all organisms, where betaine can be found, it is present as a bipolar molecule. In feedstuff, this form is labeled as betaine anhydrous. Besides the natural betaine, synthetic products are also available as betaine anhydrous. Synthetic production starts with a reaction of trimethylamine and chloroacetic acid. Therefore, synthetic betaine is additionally available as betaine hydrochloride (betaine-HCl). Betaine-HCl is often used in premixes as it is less hygroscopic and easier to handle than anhydrous powder products. The strong water attraction is a good indicator of the strong osmotic power of betaine anhydrous.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Betaine’s effects as an osmolyte on intestinal level.","type":"text"}]},{"type":"paragraph","content":[{"text":"After intestinal absorption, enterocytes can accumulate betaine and use its osmotic power to maintain their osmoregulation. This reduces the demand for energy-consuming ion pump activity and supports the cells to maintain their function during stress periods.","type":"text"}]},{"type":"paragraph","content":[{"text":"Stressors can be climate conditions (high temperature-humidity-index), where betaine anhydrous has a supportive effect on water and electrolyte balance. Consuming less energy for osmoregulation means avoiding additional metabolic heat production and the associated involuntary reduction of feed intake in that particular situation.","type":"text"}]},{"type":"paragraph","content":[{"text":"Betaine supports the cells to maintain their normal function during other challenges for the intestinal enterocytes, such as coccidiosis infections or diarrhea situations. This improves intestinal integrity and reduces the negative impact of these diseases on animal performance and well-being. All this support of intestinal osmoregulation is based on the presence and accumulation of betaine. Therefore, it is also available for metabolism with a slight delay.","type":"text"}]},{"type":"heading","attrs":{"level":1},"content":[{"text":"Betaine’s effects as a methyl group donor on metabolic level.","type":"text"}]},{"type":"paragraph","content":[{"text":"Methyl groups are non-independent molecules. As a one-carbon group (CH3), they are always part of larger compounds. Transmethylation is a core process in the endogenous synthesis of vital substances. In the methylation pathway, methionine plays a central role as S-adenosyl methionine (SAM) donates the methyl groups and converts to homocysteine. It can be irreversibly transformed to cysteine or remethylated to methionine if a methyl group donor is available to avoid an accumulation of the cytotoxic homocysteine. Betaine delivers this methyl group via the enzyme BHMT (betaine-homocysteine-methyltransferase). A high level of betaine can directly increase transmethylation since this is the betaine's primary pathway in the metabolism. In contrast, choline has other basic functions and before acting as a methyl group donor, it has to undergo a two-step oxidation. For this reason, choline has a lower efficiency in increasing the availability of methyl groups.","type":"text"}]},{"type":"paragraph","content":[{"text":"Following processes require methyl groups:","type":"text","marks":[{"type":"bold"}]}]},{"type":"bullet_list","content":[{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"DNA/RNA synthesis and regulation of the gene activation by methylation","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"Protein synthesis and tissue repair","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":" Detoxification- and immune functions","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":" Adrenaline, carnitine and creatine synthesis","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":" Phosphatidylcholine (lecithin) synthesis from phosphatidylethanolamine","type":"text"}]}]}]},{"type":"paragraph","content":[{"text":"The demand for transmethylation is variable and often underestimated. Poultry diets typically have a significant safety margin of methionine to avoid performance depression in case of an increased need for methyl groups. Betaine can take over this role and be a kind of buffer stock.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Betaine’s effects as a glycine precursor on nutritional level.","type":"text"}]},{"type":"paragraph","content":[{"text":"After delivering the first methyl group, dimethylglycine and monomethylglycine will transfer the other methyl groups into THF (tetrahydrofolate) cycle. Finally, betaine ends up as glycine and increases the glycine + serine availability. These amino acids are interchangeable and non-essential, but there is much evidence that they become limiting in high productive animals fed with low crude protein diets. Glycine is needed for the synthesis of bile acid, keratin, and uric acid. It is also part of the endogenous antioxidant glutathione. One of the serine functions is the involvement in transforming homocysteine to cysteine—a direct link to the methylation cycle.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Animals’ response to betaine supplementation.","type":"text"}]},{"type":"paragraph","content":[{"text":"The use of a high dosage of betaine, preferably in anhydrous form, can support animal productivity in different ways. Many satisfied customers and several farm trials give us confidence that betaine improves intestinal integrity and optimizes nutrient availability. Animals respond with higher performance, improved carcass quality and lower mortality. Positive effects are often also observed where it was not expected. This is an indicator that betaine compensates for imbalances and helps to maintain performance during stressful situations.","type":"text"}]}]},"_uid":"4c39d992-a313-4d96-bfd9-c85bdf643db9","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"Betaine – An Often Underestimated Feed Additive - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/6000x4000/10a60203c0/betaine-feed-additive.jpeg","og_title":"Betaine – An Often Underestimated Feed Additive - Biochem","description":"Betaine is often underestimated. But it is full of useful properties for improving animal performance and health. Read how betaine can help to improve osmoregulation, act as an alternative methyl group supplier and increase glycine availability.","twitter_image":"https://a.storyblok.com/f/190033/6000x4000/10a60203c0/betaine-feed-additive.jpeg","twitter_title":"Betaine – An Often Underestimated Feed Additive - Biochem","og_description":"Betaine is often underestimated. But it is full of useful properties for improving animal performance and health. Read how betaine can help to improve osmoregulation, act as an alternative methyl group supplier and increase glycine availability.","twitter_description":"Betaine is often underestimated. But it is full of useful properties for improving animal performance and health. Read how betaine can help to improve osmoregulation, act as an alternative methyl group supplier and increase glycine availability."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Betaine is often underestimated. But it is full of useful properties for improving animal performance and health. Read how betaine can help to improve osmoregulation, act as an alternative methyl group supplier and increase glycine availability.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"Search_Tags":[],"Published_on":"2021-03-16 00:00","Animal_Species":[],"Feed_Solutions":[],"canonical_link":""},"slug":"betaine-an-often-underestimated-feed-additive","full_slug":"news/articles/betaine-an-often-underestimated-feed-additive","sort_by_date":null,"position":20,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"57e4ce16-11ca-422c-95c8-3c564ef69210","first_published_at":"2021-03-16T11:34:00.000Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/betaine-an-often-underestimated-feed-additive","translated_slugs":[{"path":"news/articles/betain-ein-oft-unterschaetztes-futteradditiv","name":"Betain – ein oft unterschätztes Futteradditiv.","lang":"de","published":true},{"path":"news/articles/betaina-un-aditivo-para-piensos-a-menudo-subestimado","name":"Betaína - un aditivo para piensos a menudo subestimado.","lang":"es","published":true},{"path":"news/articles/betaina-um-aditivo-alimentar-frequentemente-subestimado","name":"Betaína - um aditivo alimentar frequentemente subestimado.","lang":"pt-br","published":true}]},{"name":"The mightiest methyl-group donor","created_at":"2023-05-31T10:14:53.213Z","published_at":"2025-01-31T07:48:18.967Z","updated_at":"2025-01-31T07:48:19.017Z","id":316342836,"uuid":"8170b367-0c3a-4570-8970-a90afad18066","content":{"Tags":[{"_uid":"23d64b98-c22d-4532-a425-c419ea1ace98","Products":["0624700d-72ab-4012-8013-8785f081fbce","8ae1a0c1-a663-4df1-8a09-90307f34cf67","c616d010-1662-4b95-a5fd-54cc969abda7","a87420ff-9300-4f79-89c7-bb08456a496b","bded2ce6-9dee-4c9d-bbeb-ce111ae2c0fb"],"component":"Tags","Animal_Species":["888ff53a-18a3-46b2-8333-ff560e35e5a1","fd1eeff1-3fec-434c-8cbc-39e38f966007","55d3b968-2ba6-474c-8926-7cf0e779b6e0"],"Feed_Solutions":["abc9dcbc-1d46-4635-b3a9-26b833e011c1","6b994c69-a560-4fc5-9942-3a00876716f2"]}],"Time":"10 min read","_uid":"b44837fc-8f41-44f4-a88f-f047b6431aba","Image":{"id":12039437,"alt":"The Mightiest Methyl-group Donor","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/600x400/638e43e7d4/the-mightiest-methyl-group-donor.jpg","copyright":"","fieldtype":"asset","meta_data":{},"is_external_url":false},"Title":"The Mightiest Methyl-group Donor.","Author":"Biochem Team","Content":{"type":"doc","content":[{"type":"heading","attrs":{"level":1},"content":[{"text":"Oral rehydration in calves","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"Approximately 25–40% of the estimated 264 million calves born each year will be replacements for dairy cows that are removed from the herd. The current crop of female calves will become tomorrow's herd. The stakes cannot be higher for the outlook of the dairy farm—rearing healthy, productive cows are crucial to future success. However, the path to healthy calves is paved with obstacles ranging from failure of passive transfer to a multitude of infectious diseases.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Today, as throughout history, diarrhea poses a major threat to the health of a calf in the first weeks of life. A study of on-farm mortality in the UK showed that between 2011 and 2018, 25% of all deaths occurred in cattle under 3 months of age [1]. In fact, diarrhea in calves is the most economically significant disease on a dairy farm. In a 2020 survey, 81% of UK farmers had seen diarrhea in calves during the previous 12 months and 50% had lost animals to the disease over the same period. Another UK-based study has shown that diarrhea is the main cause of mortality in calves younger than two months [2].","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Many causes - one result","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"Diarrhea in calves is not a single disease. Rather, it is a manifestation of the many infectious and non-infectious causes associated with it. From the moment of calving, a newborn calf is exposed to numerous pathogens—bacteria, viruses, parasites, protozoa—all of which harm the intestinal tract and cause diarrhea. The most common bacteria responsible for diarrhea are E. coli, Salmonella, and Clostridium perfringens; viral and protozoal causes include rotavirus, coronavirus, bovine viral diarrhea virus, cryptosporidium, and coccidia.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Non-infectious causes of calf diarrhea include inadequate nutrition, unsanitary pens, overcrowding, and inadequate colostrum intake. Colostrum intake is crucial for passive immunity and the development of a functioning immune system. Lack of colostrum feeding increases the risk of various infections and causes a higher sensitivity to environmental pathogens. Ensuring sufficient colostrum intake is vital for future health. A calf should drink at least 3–4 liters of good-quality colostrum within the first four hours of life.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Although there are several forms of diarrhea, the secretory and osmotic forms are common among calves, and because of the numerous causes, a calf may often have both forms simultaneously. Secretory diarrhea involves toxins binding to intestinal cells, which allows fluid to move into the intestinal lumen. A common cause of this type of diarrhea is E. coli. Osmotic diarrhea results from a disruption of intestinal structures leading to unabsorbed nutrients, thereby creating an osmotic gradient, pulling fluid into the lumen.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Regardless of the form and the cause, the clinical signs of diarrhea are similar. Most noted is a decreased appetite and fluid intake, fever (usually over 40°C), and a weak appearance with sunken eyes. A severe case may present lying down with a low body temperature (cold to the touch). The fecal consistency may appear differently depending on the severity, alternating between greasy and fluid. Affected calves also show an increased frequency of defecation.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Metabolic acidosis - the next phase","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"In calves, metabolic acidosis is a common result of diarrhea-induced dehydration. Without treatment, metabolic acidosis is a prime factor in the death of many of these calves. Early and intensive oral electrolyte therapy at the onset of diarrhea in calves is critical to replenish fluids and correct metabolic acidosis. Therapy should be started as soon as possible regardless of whether evidence of dehydration is seen. The clinical signs of dehydration are not obvious until the calf has lost at least 6% of its body weight in fluid (figure 1). The course of therapy depends on the severity of symptoms. Calves still able to stand and suckle can often be treated with oral rehydration solutions alone to avoid continued fluid losses and restore extracellular cell fluid volume. If there are signs of systemic illness, a veterinarian should be consulted for additional therapies such as anti-inflammatories or intravenous fluids.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"type":"image","attrs":{"id":9273987,"alt":"","src":"https://a.storyblok.com/f/190033/1220x422/352e310604/3-1.png","title":"","source":"","copyright":"","meta_data":"[object Object]"}},{"text":"Keep calves eating!","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"Calves must eat. A sufficient energy intake is essential to maintain the calf's defense against infections while continuing to grow and develop. Calves have large energy requirements and little energy reserves. Since electrolyte solutions do not meet calf energy requirements; milk should not be withheld. Although feeding milk may increase fecal volume, it also provides a critical energy supply and may promote gut healing. Additionally, free access to drinking water should be provided.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Rehydration solutions are not all the same","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"“They are all the same to me!” This is a common thought among farmers when thinking about rehydration solutions for calves. With so many products available, it can be difficult to choose. However, selecting an oral rehydration solution is important. It should be effective and easily added to the daily milk ration. It should also meet the goals of oral rehydration therapy, such as the correction of dehydration through normalization of the extracellular fluid volume, provision of additional energy, supply of a buffer to prevent or correct metabolic acidosis and increase sodium and water absorption from the intestines.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"The alkalizing ability of an oral rehydration solution is dependent on the alkalizing agent. Alkalizing agents, more commonly known as buffering agents, are used to counteract acidosis. Oral electrolyte solutions have traditionally contained sodium bicarbonate because it has been shown to be highly effective. However, bicarbonate has several disadvantages. High concentrations of bicarbonate alkalize the abomasum, which interferes with abomasal milk clotting. The use of bicarbonate in rehydrating solutions could lead to a higher number of coliform bacteria that reach the small intestine, thus increasing the severity, duration, and mortality risk.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Other commonly used alkalizing agents include acetate and propionate—both with a similar alkalizing ability to bicarbonate. However, these agents offer additional benefits that bicarbonate does not. Unlike bicarbonate, acetate and propionate exert their alkalizing effects after they are absorbed and metabolized. These alkalizing agents help facilitate sodium and water absorption, produce energy when metabolized, and do not alkalinize the abomasum or interfere with milk clotting (figure 2). The administration of oral rehydration solutions containing acetate or propionate in milk or milk replacer have shown to be beneficial. Calves that have been fed with milk recover quicker and perform better than those that are taken off milk.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"type":"image","attrs":{"id":9273989,"alt":"","src":"https://a.storyblok.com/f/190033/1220x423/ceaa6c052b/3-2.png","title":"","source":"","copyright":"","meta_data":"[object Object]"}},{"text":"Combating the negative impact of diarrhea","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]}]},{"type":"paragraph","content":[{"text":"A large amount of sodium and potassium are lost when a calf has diarrhea. This can result in a lowering of blood pH (metabolic acidosis), which cannot be corrected without intervention. An oral rehydration solution must be capable of efficiently buffering (counteracting) the low blood pH. The efficiency of the buffering capacity of an oral rehydration solution is defined by the strong ion difference (SID value). For moderate acidosis, oral rehydration solutions with a high SID formulation can help—an effective oral rehydrating solution should have a SID value between 60 and 80.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Calves with diarrhea not only have a reduced ability to absorb nutrients. They also have an increased demand for energy for immune function and intestinal epithelium repair. Increasing sodium absorption is one of the functions of an oral rehydration solution and cannot be achieved without an energy source. Therefore, oral rehydration solutions should provide an energy source—often in the form of sucrose or glucose.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Formulated with sodium propionate, betaine, zinc, and glucose, Prolyt Pack® Extra meets all the requirements of an effective oral rehydrating solution. Prolyt Pack® Extra has a SID value of 79—a highly effective buffer. The propionate in Prolyt Pack® Extra serves several functions. As an alkalizing agent, propionate does not alter the pH in the abomasum, which means there is no interference with milk clotting. Propionate also enhances sodium absorption in the small intestine and can be a source of energy for the calf.","type":"text"},{"type":"hard_break"},{"type":"hard_break"},{"text":"Betaine is included in the formula to function as an osmolyte to improve cellular hydration. When betaine is taken up by the cells, they can maintain water volume without having to increase ion levels thus reducing ion pump use during hyperosmotic stress. The result is that less energy is needed to maintain the osmotic balance. Prolyt Pack® Extra also contains organically bound zinc to regenerate damaged intestinal epithelium and improve intestinal barrier function, helping the calf quickly return to performance levels.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Prolyt Pack® Extra","type":"text","marks":[{"type":"textStyle","attrs":{"color":"rgb(149, 193, 31)"}}]},{"text":" is easily added to the milk or milk replacer","type":"text"},{"type":"hard_break"},{"text":"- act early to restore your calf's water balance!","type":"text"}]},{"type":"paragraph","content":[{"text":"Hyde, R.M., et al., Quantitative analysis of calf mortality in Great Britain. Journal of Dairy Science, 2020. 103(3): p. 2615-2623.","type":"text"},{"type":"hard_break"},{"text":"Johnson, K.F., et al., Prospective cohort study to assess rates of contagious disease in pre‐weaned UK dairy heifers: management practices, passive transfer of immunity and associated calf health. Veterinary Record Open, 2017. 4(1): p. e000226.","type":"text"}]}]},"Sections":[{"Text":{"type":"doc","content":[{"type":"heading","attrs":{"level":2},"content":[{"text":"The Case for Betaine.","type":"text","marks":[{"type":"bold"}]}]},{"type":"paragraph","content":[{"text":"It all begins with the methyl-group. Methyl-groups are highly stable molecules composed of one central carbon atom bonded to three hydrogen atoms. They do not exist solitarily—but rather as part of a larger molecule. They are involved in methylation—a process by which the entire group transfers to another molecule. This process is an extremely important metabolic process that imparts a sizable influence on cellular functions. ","type":"text"}]},{"type":"paragraph","content":[{"text":"Methyl-group metabolism is a metabolically demanding process that has significant nutritional implications. The availability of methyl groups is vital for RNA and DNA synthesis, gene regulation, immune function, protein synthesis, and fatty acid metabolism. The more than 50 critical methylation pathways all share the same need for a common substrate—methyl-groups. During growth and development, these pathways are highly active, not only for maintaining basic functions but also to meet the demands for growth. ","type":"text"}]},{"type":"paragraph","content":[{"text":"Animals cannot synthesize methyl-groups and thus need to receive them via feed. The animal’s primary source of methyl groups come methionine—however, methionine is not only the primary source of methyl groups but also is required for protein synthesis. Once methionine gives up its methyl-group, the resulting cytotoxic molecule—homocysteine—can either be re-methylated (when there are additional sources of methyl-groups) or converted to cysteine when there are no available methyl-groups for re-methylation. ","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Adding methyl-groups to the system.","type":"text","marks":[{"type":"bold"}]}]},{"type":"paragraph","content":[{"text":"There are several molecules that function as a source of additional methyl-groups—namely folate, choline, betaine. Choline is—and has been—added to the feed as a methyl donor and to spare methionine. Choline is a pro-vitamin that is required at a much higher level than other vitamins. Typically thought of as a methyl-group donor, choline has its own important functions in the body: ","type":"text"}]},{"type":"bullet_list","content":[{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"As a precursor for neurotransmitter synthesis ","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"As a required constituent of cell membranes ","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"As a component needed for fat metabolism in the liver ","type":"text"}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"As a methyl group donor after being oxidized to betaine ","type":"text"}]}]}]},{"type":"paragraph","content":[{"text":"Unlike most vitamins, choline can be synthetized by the majority of animal species. However, synthesis may become insufficient requiring supplementation in the diet. The need for dietary supplementation depends on the species and age of the animal as well as the amount of choline contained in the feed’s raw materials. It should be noted, though, that most feedstuffs contain enough choline to meet the animal’s basic needs. Additional choline added to the feed formulation will be mainly a source of additional methyl groups. ","type":"text"}]},{"type":"paragraph","content":[{"text":"The most common choline source for addition to the diet is choline chloride. However, despite widespread use, choline chloride has several disadvantages. Choline chloride interacts adversely with vitamins—studies have demonstrated that in premixes with added choline chloride, vitamins K, C, B","type":"text"},{"text":"1","type":"text","marks":[{"type":"subscript"}]},{"text":", and A stability decreased dramatically compared to premixes without choline chloride. ","type":"text"}]},{"type":"paragraph","content":[{"text":"Choline chloride is incompletely absorbed in the intestine—often requiring a high inclusion rate. The risk of unabsorbed choline chloride is the transformation into trimethylamine by intestinal microbiota, which can be absorbed and is associated with a fishy smell in eggs. Additionally, the manufacture of synthetic choline chloride uses ethylene oxide—another possible risk of contamination. Choline chloride has a corrosive nature and can damage feed mill equipment. ","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Now, it's time for betaine! ","type":"text","marks":[{"type":"bold"}]}]},{"type":"paragraph","content":[{"text":"Betaine, like choline and methionine, is an important donator of methyl groups, which can reduce the requirements for other methyl group donors. It is a natural compound widely distributed in plants, animals, and microorganisms. Betaine can be formed from the oxidation of choline or obtained from the diet. Both the kidneys and liver express transport systems that take up betaine from the blood. The liver stores betaine where it functions primarily as a methyl donor (figure 1). ","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":12040021,"alt":"Figure 1 Betain role in methlyation cycle","src":"https://a.storyblok.com/f/190033/8819x7907/14388e23cc/figure-1-betain-role-in-methlyation-cycle.png","title":"","source":"","copyright":"","meta_data":{"size":"6668x4144"}}},{"text":"Figure 1. Betaine’s role in the methylation cycle (adapted from Eklund etal., 2005).","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Increasing stress—such as heat stress—increases an animal’s need for methyl groups. Moreover, this need is not fixed and changes with time and conditions. Ensuring a ready supply of methyl groups in the liver allows for optimal performance and resistance to stressors. Betaine is the ideal molecule to achieve this—not only is it more efficient than choline chloride, with its wide margin if safety, betaine is a better option than increasing methionine. A high betaine concentration in the liver maximizes the availability of methyl groups imparting a resilience that is key for successful animal production.","type":"text"}]},{"type":"paragraph","content":[{"text":"Two forms of betaine are often used as feed additives—anhydrous betaine, and betaine hydrochloride. Betaine anhydrous is a bipolar molecule similar to natural betaine whereas betaine hydrochloride is a synthetic molecule. Betaine has numerous advantages over choline chloride in diets. Betaine is a much more efficient supplier of methyl groups than choline. Before it can serve as a methyl-group donor, choline must be oxidized to betaine—supplying betaine in the diet eliminates this step. It has been demonstrated that, compared to betaine, choline is only 55% as efficient in supplying methyl groups. Moreover, since betaine has a lower molecular weight than choline chloride, you get more bang for your buck. Betaine is 2.17 times more efficient in donating methyl groups compared to choline chloride.","type":"text"}]},{"type":"paragraph","content":[{"text":"Betaine can be especially helpful in poultry diets. To maintain the optimal electrolyte balance, a balanced supply of cations (Na","type":"text"},{"text":"+","type":"text","marks":[{"type":"superscript"}]},{"text":" and K","type":"text"},{"text":"+","type":"text","marks":[{"type":"superscript"}]},{"text":") and anions (Cl","type":"text"},{"text":"-","type":"text","marks":[{"type":"superscript"}]},{"text":") are necessary. When adding choline chloride to poultry diets as a methyl group donor, there is often an increase in chloride anions. As such, the addition of sodium bicarbonate is used to increase sodium cations, which is inefficient and costly. Betaine has a chloride sparing effect. Replacing choline chloride with betaine means that less sodium bicarbonate is used in the formulation and chloride anions can be balanced with sodium chloride for a cost savings.","type":"text"}]},{"type":"paragraph","content":[{"text":"One further advantage to betaine use over choline chloride—specifically betaine anhydrous—is its osmolyte effect. Osmolytes are small compounds that are accumulated by cells during stressful external conditions. As an osmolyte, betaine increases water retention in the call. Betaine will also protect cellular structures such as proteins, enzymes, and DNA and is very important for cells experiencing osmotic stress. Lastly, betaine does not react with, and may even be protective of, sensitive vitamins in premixes or feed and is non-destructive to feed mill equipment.","type":"text"}]},{"type":"paragraph","content":[{"text":"Hepatron","type":"text","marks":[{"type":"link","attrs":{"href":"/products/hepatron-95","uuid":"a87420ff-9300-4f79-89c7-bb08456a496b","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"superscript"}]},{"text":" is a range of liquid and powder betaine feed additives that are an efficient solution for increasing the availability of methyl-groups. ","type":"text"},{"text":"Hepatron","type":"text","marks":[{"type":"bold"}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"superscript"}]},{"text":" ","type":"text","marks":[{"type":"bold"}]},{"text":"offers superior flexibility in its application—add it to premixes or directly into the feed mixer.","type":"text"},{"text":" Hepatron","type":"text","marks":[{"type":"bold"}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"superscript"}]},{"text":" consists of several established betaine products that vary in their effects, handling, and costs. We have years of experience using betaine and offer a comprehensive selection of ","type":"text"},{"text":"Hepatron","type":"text","marks":[{"type":"bold"}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"superscript"}]},{"text":" products to meet your individual feed needs. Contact us to find out how any of the ","type":"text"},{"text":"Hepatron","type":"text","marks":[{"type":"bold"}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"superscript"}]},{"text":" family can benefit you and your animals.","type":"text"}]},{"type":"paragraph","content":[{"text":"Although betaine is not able to replace the primary and essential functions of choline, it can deliver methyl-groups quicker and with less energy loss than choline chloride. Adding betaine to the feed allows methionine and choline do their crucial work—if you are adding choline chloride to your formulation to increase methyl-groups, then betaine is the better bet!","type":"text"}]},{"type":"paragraph","content":[{"text":"Leave the methyl-group donating to the mightiest methyl-group donor—betaine!","type":"text","marks":[{"type":"bold"}]}]}]},"_uid":"e2202e51-654e-45cb-b8b8-3c89233e8685","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"The Mightiest Methyl-group Donor - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/600x400/638e43e7d4/the-mightiest-methyl-group-donor.jpg","og_title":"The Mightiest Methyl-group Donor - Biochem","description":"Learn about the advantages of betaine as a source of methyl groups, including its natural presence in plants and animals and its ability to decrease the need for other methyl donors.","twitter_image":"https://a.storyblok.com/f/190033/600x400/638e43e7d4/the-mightiest-methyl-group-donor.jpg","twitter_title":"The Mightiest Methyl-group Donor - Biochem","og_description":"Learn about the advantages of betaine as a source of methyl groups, including its natural presence in plants and animals and its ability to decrease the need for other methyl donors.","twitter_description":"Learn about the advantages of betaine as a source of methyl groups, including its natural presence in plants and animals and its ability to decrease the need for other methyl donors."},"Description":"Learn about the advantages of betaine as a source of methyl groups, including its natural presence in plants and animals and its ability to decrease the need for other methyl donors.","Search_Tags":[],"Published_on":"2023-02-06 00:00","Animal_Species":[],"Feed_Solutions":[],"canonical_link":""},"slug":"the-mightiest-methyl-group-donor","full_slug":"news/articles/the-mightiest-methyl-group-donor","sort_by_date":null,"position":20,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"e508f73f-85bd-473f-afbd-b981d2b45987","first_published_at":"2023-09-20T11:15:45.563Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/the-mightiest-methyl-group-donor","translated_slugs":[{"path":"news/articles/der-maechtigste-methylgruppenlieferant","name":"Der mächtigste Methylgruppenlieferant.","lang":"de","published":true},{"path":"news/articles/el-donante-de-grupos-metilo-mas-poderoso","name":"El donante de grupos metilo más poderoso.","lang":"es","published":true},{"path":"news/articles/o-mais-poderoso-doador-de-grupo-metil","name":"O mais poderoso doador de grupo metil.","lang":"pt-br","published":true}]},{"name":"How Yeast Cell Walls Are Shaping the Future of Poultry Production.","created_at":"2025-03-24T08:06:33.633Z","published_at":"2025-03-27T12:46:54.756Z","updated_at":"2025-03-27T12:46:54.849Z","id":644224085,"uuid":"eac597ef-7f49-44dd-b81f-13ee2d115438","content":{"Tags":[{"_uid":"8f9c3283-ed2d-470e-8d7a-f9c6837e4e0f","Products":["b3dda12e-2aa9-4511-820b-433933286824"],"component":"Tags","Animal_Species":["888ff53a-18a3-46b2-8333-ff560e35e5a1"],"Feed_Solutions":[]}],"_uid":"b511f6b3-b968-41a1-a5cb-5f8178bda64f","Image":{"id":21493179,"alt":"How Yeast Cell Walls Are Shaping the Future of Poultry Production","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/7360x4912/e54b8375ac/how-yeast-cell-walls-are-shaping-the-future-of-poultry-production.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"How Yeast Cell Walls Are Shaping the Future of Poultry Production","title":"","source":"","copyright":""},"is_external_url":false},"Title":"How Yeast Cell Walls Are Shaping the Future of Poultry Production.","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":"language-html"},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"The world’s population continues to grow and is expected to reach 9.6 billion by 2050. To meet the food needs of this growing population, inter alia poultry production has increased significantly. Global poultry meat production rose to almost 140 million tons in 2023, significantly exceeding pork production. This means poultry has become one of the largest and most important agricultural sectors, providing an important source of protein. The market for poultry meat is growing rapidly, with consumption projected to increase by 65%.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Advances Driving Poultry Productivity.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"This impressive growth in the poultry industry has been driven by remarkable advances in nutrition, housing, management practices, and genetics. Poultry production has improved enormously in the last 30 years built on higher growth rates, better egg production, and improved feed conversion. Improvements inter alia focused on growth rate, feed efficiency, skeletal and organ health, and egg production and quality, thus modern laying hens can maintain production for up to 100 weeks and the fattening time of broilers has been reduced to roughly 35 days. Genetic selection programs now emphasize not only productivity but also bird health and welfare.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"However, this increased productivity also means that poultry are now closer to their biological limits. As a result, factors such as nutrition, environment, and management have become even more critical. The removal of antibiotic growth promoters from feed has created new challenges in maintaining gut health and optimal bird performance.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The intestinal tract represents 70 % of a bird’s immune system, it produces and stores immune cells, supporting immunity by releasing cell-signaling proteins (cytokines) when activated. At hatch, chicks have an incomplete immune system, which develops at a few weeks of age. Thus, supporting immune defense is very important.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"As such, gut health is now recognized as one of the most important challenges in the poultry industry, affecting nutrient digestion and absorption and ultimately overall performance. Issues such as maintaining gut health during diet changes, managing rising feed costs (doing more with less) and increased pressure from pathogens such as ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Salmonella","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" are ongoing concerns.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Mounting Pathogenic Pressure.","type":"text"}]},{"type":"paragraph","content":[{"text":"Antibiotic resistance in pathogenic bacteria has become a defining public health challenge of the 21st century, impacting human and animal health. A significant contributing factor is the role of livestock and food of animal origin, which have become reservoirs for resistant pathogens, enabling their transfer to humans. Among these, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Salmonella","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" infections remain critical concerns worldwide.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Salmonella","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is recognized as a leading cause of foodborne illness worldwide and is the most critical foodborne pathogen within the EU. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"This pathogen causes millions of infections annually, resulting in a wide range of symptoms and significant economic burdens, estimated at billions of euros each year in the EU alone. The insidious nature of ","type":"text"},{"text":"Salmonella","type":"text","marks":[{"type":"italic"}]},{"text":"’s transmission, often occurring without obvious signs in birds, underscores the urgent need for effective strategies to reduce its prevalence at the farm level to safeguard the food chain.","type":"text"}]},{"type":"paragraph","content":[{"text":"E. coli","type":"text","marks":[{"type":"italic"}]},{"text":" is one of the most commonly occurring and economically devastating bacterial infections of poultry worldwide, resulting in multimillion dollar losses annually, restricting the development of the poultry industry. Naturally ","type":"text"},{"text":"found in the intestines of poultry, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" has also great capacity to cause serious infections","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" and is ","type":"text"},{"text":"responsible for high morbidity and mortality, with high levels of colonization. Whereas ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Salmonella","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" infection mostly impacts on the human population as a foodborne illness, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" has greater effects on birds themselves causing devastating disease and losses.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Yeast Cell Walls: A Natural Defense.","type":"text"}]},{"type":"paragraph","content":[{"text":"Yeasts have been integral to animal nutrition due to their rich nutritional content and their ability to enhance gut health. In poultry nutrition, mainly inactive, prebiotic yeast products are used, often in the form of yeast cell wall products. The yeast cell wall, a complex structure providing shape and strength, contains various components such as β-glucans, mannan-oligosaccharides (MOS), proteins, lipids, and chitin.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Among these, β-glucans and MOS are the primary active components responsible for the yeast cell wall’s beneficial properties. MOS are located in the outer layer, while β-glucans are found in the inner layer. These two yeast cell wall components exert inter alia prebiotic effects, favoring healthy bacteria like ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"lactobacilli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"bifidobacteria","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":".","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The usage of yeast cell walls aims to reduce pathogens by high MOS levels & stimulate the immune system by an adequate proportion of β-Glucans. These two components of the yeast cell wall are able by their specific outer structure either to bind on gram-negative pathogens making them harmless or trigger immune cells for increased immune defending capacities.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Pathogen Reduction: ","type":"text"},{"text":"Displacement of Pathogens by MOS","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":".","type":"text"}]},{"type":"paragraph","content":[{"text":"Mannan oligosaccharides have been shown to reduce the incidence of gram-negative pathogens like ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Salmonella","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"by binding them, mitigating their adverse effects. Additionally, MOS supports a positive gut microbiota (eubiosis), which helps to get higher protection against harmful bacteria, reducing both the infection and transmission.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Adhesion to host tissues is a critical event in gram-negative pathogenesis, with type-1 fimbriae being one of the most common adhesive structures in this family.","type":"text"},{"text":" ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"These fimbriae are important virulence factors. ","type":"text"},{"text":"Bacteria with these fimbriae can adhere to receptors of the intestinal wall, which is the first step of bacterial infection.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Due to their specific structure, MOS are able to bind to the type-1-fimbriae of gram-negative bacteria like ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Salmonella","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", preventing the adhesion of the pathogen to the intestinal wall and reducing its virulence (Figure 1). The complex of MOS and bacteria is then excreted in the feces. For a highly efficient binding, however, a large amount of small-particle-sized MOS is necessary.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21493974,"alt":"","src":"https://a.storyblok.com/f/190033/2880x1400/a3477d9c09/figure-1-mos-can-bind-to-the-type-1-fimbriae-of-gram-negative-bacteria.jpg","title":"","source":"","copyright":"","meta_data":{}}},{"text":"Figure 1: MOS can bind to the type-1 fimbriae of gram-negative bacteria, reducing adhesion to the intestine, inhibiting multiplication, and facilitating their removal ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"(diagrammatic illustration)","type":"text","marks":[{"type":"italic"}]},{"text":".","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Immune Stimulation: Boosting Birds’ Defenses.","type":"text"}]},{"type":"paragraph","content":[{"text":"Research shows that β-glucans from yeast cell walls can stimulate both innate, the first line of defense against pathogens, and acquired immunity. β-glucans are known activators of macrophages—a type of white blood cell that consumes and digests pathogens—and can also enhance acquired immunity by activating T-cells. Moreover, β-glucans can induce B cells to produce IgG immunoglobulin and stimulate cytokine production and release (Figure 2).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21493973,"alt":"","src":"https://a.storyblok.com/f/190033/2925x1295/b6a40ee119/1-6-glucans-diagrammatic-illustration.jpg","title":"","source":"","copyright":"","meta_data":{}}},{"text":"Figure 2: Immune system activation by β -1,3/1,6-glucans (diagrammatic illustration).","type":"text","marks":[{"type":"italic"}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"TechnoMos®: Elevating Quality and Thus Health","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"TechnoMos®","type":"text","marks":[{"type":"link","attrs":{"href":"/products/technomos","uuid":"b3dda12e-2aa9-4511-820b-433933286824","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"is a premium yeast cell wall product, derived from a primary grown yeast, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Saccharomyces cerevisiae","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", fermented under highly controlled conditions. This manufacturing process is focused on producing a unique product with a consistent quality. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®’s","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" quality is directly linked to the level of active ingredients like MOS and β-glucans.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"TechnoMos®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" features a high content of MOS and the right amount of β-1,3/1,6-glucans with a particularly small particle size for optimal efficacy. This means ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos® ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"excels in its ability to bind gram-negative bacteria such as ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Salmonella ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", while providing effective immune stimulation and favoring a healthy environment for the growth of positive microbiota (Figure 3). This results in improved production measures like increased daily weight gain and feed conversion rate (Figure 4).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21493976,"alt":"Figure 3: TechnoMos® supplementation at different dosages reduces ileal count of Salmonella spp","src":"https://a.storyblok.com/f/190033/6000x2917/e29fe41cfb/figure-3-technomos-supplementation-at-different-dosages-reduces-ileal-count-of-salmonella-spp.webp","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 3: TechnoMos® supplementation at different dosages reduces ileal count of Salmonella spp","title":"","source":"","copyright":""}}},{"text":"Figure 3: ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®","type":"text","marks":[{"type":"bold"},{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" supplementation at different dosages reduces ileal count of Salmonella spp. and increases beneficial ileal Lactobacillus spp. count in 70 days old laying hens under E. coli challenging conditions; different letters indicate significant differences ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"ab","type":"text","marks":[{"type":"italic"},{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" P<0.05","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21493975,"alt":"Figure 4: Body weight gain and feed conversion rate after 42 days of growth in broilers","src":"https://a.storyblok.com/f/190033/2880x1400/b7706bafa4/figure-4-body-weight-gain-and-feed-conversion-rate-after-42-days-of-growth-in-broilers.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 4: Body weight gain and feed conversion rate after 42 days of growth in broilers","title":"","source":"","copyright":""}}},{"text":"Figure 4: Body weight gain and feed conversion rate after 42 days of growth in broilers treated with ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®","type":"text","marks":[{"type":"bold"},{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" during starter (0.1%), grower (0.1%) and finisher (0.05%) phase compared to a non-treated control under a semi-challenged housing conditions (no cleaning, no disinfection, no coccidiostats); different letters indicate significant differences; ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"ab ","type":"text","marks":[{"type":"italic"},{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"P<0.05, ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"AB","type":"text","marks":[{"type":"italic"},{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" P<0.1","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Compared to by-product yeasts, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®","type":"text","marks":[{"type":"link","attrs":{"href":"/products/technomos","uuid":"b3dda12e-2aa9-4511-820b-433933286824","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"as a primary grown yeast","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"exhibits excellent quality stability and a typical yeast odor and typical yeast flavor. Additionally, the low starch and adequate protein level in ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" can be seen as an indicator for a pure yeast cell wall product. In poultry flocks infected with","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" Salmonella ","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"or ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"E. coli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", using ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" can contribute to a reduced shedding rate, thus minimizing the spread of these pathogens in the environment. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos® ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"is part of a multifaceted approach that helps maintain a balanced gut microbiota, promoting overall health, disease resilience, and improved performance.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"_uid":"e3d9de26-9c0e-4d6d-85fa-c0d1e8c688bc","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"cb4b0296-e4da-4259-9076-65b86af43005","title":"Poultry Gut Health: Natural Defense with Yeast Cell Walls","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/7360x4912/e54b8375ac/how-yeast-cell-walls-are-shaping-the-future-of-poultry-production.jpeg","og_title":"Poultry Gut Health: Natural Defense with Yeast Cell Walls","description":"Combat poultry pathogens like Salmonella & E. coli naturally with yeast cell walls. TechnoMos® boosts gut health, immunity & performance without antibiotics. Read more!","twitter_image":"https://a.storyblok.com/f/190033/7360x4912/e54b8375ac/how-yeast-cell-walls-are-shaping-the-future-of-poultry-production.jpeg","twitter_title":"Poultry Gut Health: Natural Defense with Yeast Cell Walls","og_description":"Combat poultry pathogens like Salmonella & E. coli naturally with yeast cell walls. TechnoMos® boosts gut health, immunity & performance without antibiotics. Read more!","twitter_description":"Combat poultry pathogens like Salmonella & E. coli naturally with yeast cell walls. TechnoMos® boosts gut health, immunity & performance without antibiotics. Read more!"},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Poultry production is soaring to meet the protein needs of a rapidly expanding global population. With antibiotic restrictions and pathogen pressure pushing birds to their limits, gut health is now mission-critical for success. Discover how yeast cell walls like ","type":"text"},{"text":"TechnoMos®","type":"text","marks":[{"type":"bold"}]},{"text":" are transforming poultry performance, supporting disease resistance, and boosting productivity.","type":"text"}]}]},"Search_Tags":[],"Published_on":"2025-03-26 00:00","canonical_link":""},"slug":"how-yeast-cell-walls-are-shaping-the-future-of-poultry-production","full_slug":"news/articles/how-yeast-cell-walls-are-shaping-the-future-of-poultry-production","sort_by_date":null,"position":-110,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"9bb22ba9-3576-4176-813b-fb82f57df3cb","first_published_at":"2025-03-27T07:39:29.081Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/how-yeast-cell-walls-are-shaping-the-future-of-poultry-production","translated_slugs":[{"path":"news/articles/wie-hefezellwaende-die-zukunft-der-gefluegelproduktion-unterstuetzen","name":"Wie Hefezellwände die Zukunft der Geflügelproduktion unterstützen.","lang":"de","published":true},{"path":"news/articles/como-las-paredes-celulares-de-levadura-estan-dando-forma-al-futuro-de-la-produccion-avicola","name":"Cómo las paredes celulares de levadura están dando forma al futuro de la producción avícola.","lang":"es","published":true},{"path":"news/articles/como-as-paredes-celulares-de-levedura-estao-moldando-o-futuro-da-producao-avicola","name":"Como as paredes celulares de levedura estão moldando o futuro da produção avícola.","lang":"pt-br","published":true}]},{"name":"Navigating Weaning Challenges: Optimizing Piglet Health and Performance.","created_at":"2025-03-24T07:26:54.920Z","published_at":"2025-03-27T08:57:53.900Z","updated_at":"2025-03-27T08:57:53.957Z","id":644215217,"uuid":"fb2629d8-d12c-422b-a14f-f6c7a8de9fee","content":{"Tags":[{"_uid":"51930652-5691-419d-976b-ac3f72d1d200","Products":["af9cac01-28d4-4ea8-af74-79da5b1b7882","b3dda12e-2aa9-4511-820b-433933286824","ab84c3e0-964b-41f6-b2ee-7fd74be2583e","772e0fa6-e94b-4293-a013-dcba3f76799f"],"component":"Tags","Animal_Species":["fd1eeff1-3fec-434c-8cbc-39e38f966007"],"Feed_Solutions":[]}],"_uid":"11f7cc79-69b5-46ee-9d50-af27767db9c4","Image":{"id":21492702,"alt":"Navigating Weaning Challenges: Optimizing Piglet Health and Performance","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/4560x3420/bfa15afb67/navigating-weaning-challenges-optimizing-piglet-health-and-performance.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"Navigating Weaning Challenges: Optimizing Piglet Health and Performance","title":"","source":"","copyright":""},"is_external_url":false},"Title":"Navigating Weaning Challenges: Optimizing Piglet Health and Performance.","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":"language-html"},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"Weaning, a critical part of swine production, is challenging for young piglets. Commercially weaned pigs transition at 3–4 weeks, much earlier than the natural weaning age of 12–17 weeks. This early separation, along with dietary changes and social regrouping, causes stress that can lead to reduced feed intake, weight loss, diarrhea, and increased mortality. Understanding these stressors and their effects on the piglet’s digestive system is essential for developing effective management and nutritional strategies to support a healthy weaning transition.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"What is a “Healthy Gut?”","type":"text"}]},{"type":"paragraph","content":[{"text":"The small intestine’s interior features finger-like projections called villi, made up of intestinal cells with smaller projections called microvilli. Intestinal cells are replaced in “crypts,” where stem cells divide and differentiate into mature intestinal cells and mucus-producing goblet cells. These cells migrate to the villus tip and are eventually shed into the intestinal lumen (Figure 1).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21492756,"alt":"Figure 1: Structure of a healthy intestinal tract","src":"https://a.storyblok.com/f/190033/2881x1434/71143691b6/figure-1-structure-of-a-healthy-intestinal-tract.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: Structure of a healthy intestinal tract","title":"","source":"","copyright":""}}},{"text":"Figure 1: Structure of a healthy intestinal tract.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Villi and microvilli increase the surface area for nutrient absorption, with villi increasing it 40-fold and microvilli 600-fold. Villi are connected to blood vessels, allowing nutrients to be used throughout the body. Thus, the intestine is a key site for nutrient digestion and absorption and an animal’s growth and performance are linked to villus height.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"The Barrier Function of the Gut.","type":"text"}]},{"type":"paragraph","content":[{"text":"The intestinal monolayer is also responsible for maintaining a strong barrier against toxins, antigens, and pathogenic microbes, preventing these substances from crossing into the body. It plays an important role in maintaining the homeostasis of the gut internal environment. This barrier can be broadly divided into three parts: a microbial barrier, a mucosal barrier, and an immunological barrier (Figure 2).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21492757,"alt":"Figure 2: The intestinal monolayer maintains a strong barrier against toxins","src":"https://a.storyblok.com/f/190033/2881x1434/80b9c69ac5/figure-2-the-intestinal-monolayer-maintains-a-strong-barrier-against-toxins.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: The intestinal monolayer maintains a strong barrier against toxins","title":"","source":"","copyright":""}}},{"text":"Figure 2: The intestinal monolayer maintains a strong barrier against toxins, antigens, and pathogenic microbes and ","type":"text","marks":[{"type":"italic"}]},{"text":"is divided into three parts: a microbial barrier, a mucosal barrier, and an immunological barrier.","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Piglets develop a diverse and complex microbial community in the gastrointestinal tract through milk consumption and exposure to the external environment. This dynamic balance between different beneficial gut microbiota constitutes the microbial barrier. The microbial barrier has three basic functions that provide a first line of defense against pathogens: 1) occupying binding and attachment sites; 2) competing with pathogenic bacteria for nutrients; and 3) improving gut function. The microbiota are frequently exposed to various antigens and microbial components from feed are particularly influenced by diet. Moreover, microbial changes can significantly impact animal growth and development.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The mucosal barrier is both mechanical and chemical. The mechanical barrier consists of healthy intestinal cells and tight junctions that close spaces between cells, controlling the movement of ions and small molecules from the gut to the bloodstream, filtering nutrients, electrolytes, and water. The chemical barrier includes mucus from goblet cells as well as bacteriostatic substances from non-pathogenic bacteria, which form a protective layer to prevent pathogenic bacteria from binding to intestinal cells.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Up to 70 % of immune cells are in the intestine, where innate and adaptive immunity work closely together to form the immunological barrier. The main method of defense is the production of secretory antibodies, primarily IgA and IgM. These non-specific antibodies protect by binding antigens near the intestinal surface or by neutralizing viruses and endotoxins within intestinal cells.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Two critical periods of maximum antigen exposure occur—one immediately after birth and one at weaning. During weaning, abrupt changes in diet and environment can alter the mucosal immune response. Understanding these interactions is essential for developing strategies to support healthy growth and development during these vulnerable periods.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Functional Changes During Weaning.","type":"text"}]},{"type":"paragraph","content":[{"text":"During weaning, piglets experience significant changes in their intestines due to abrupt shifts in diet and environment, greatly impacting piglet growth and development. Within 24 hours of weaning, villus height decreases by 75 %, usually from increased cell loss and/or decreased crypt cell production, resulting in the loss of mature intestinal cells and reduced nutrient absorption. Additionally, reduced activity of digestive enzymes such as lactase and peptidases and nutrient transporters have been correlated with shortened villus height.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The activity of digestive enzymes, including pepsin, trypsin, chymotrypsin, and amylase, undergoes a significant decline within one week of early weaning. This reduction of enzyme activity complicates feed digestion, resulting in reduced nutrient absorption, an accumulation of undigested nutrients in the intestine, and an overgrowth of potentially harmful bacteria. Weaning also causes compromised barrier function, which increases permeability and allows toxins, allergenic compounds, and bacteria to enter the body, triggering inflammatory responses.","type":"text"}]},{"type":"paragraph","content":[{"text":"The immune system in the intestine of pigs reaches an adult-like structure at around 7 weeks. As such, the weaning process also affects the immune response and the systemic development of innate and adaptive immunity. The withdrawal of milk and the introduction of new diets lead to up-regulated expression of pro-inflammatory cytokines and oxidative stress, further impairing intestinal function. Controlling intestinal inflammation processes and maintaining a normal oxidative state may alleviate subsequent intestinal disorders induced by weaning stress.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"At weaning, the abrupt changes in the diet and environment induce changes in the intestinal microbiota, with a notable decrease in beneficial bacteria like ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Lactobacilli","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and a shift toward fiber-degrading bacteria. These changes in the composition and activity of the intestinal microbial community are often correlated with pathogenic infections during weaning, highlighting the importance of managing the weaning transition to support piglet health.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Nutritional Strategies: Dietary Feed Supplements.","type":"text"}]},{"type":"paragraph","content":[{"text":"One way to reduce weaning-associated intestinal dysfunction and impaired growth is through feed additives and nutritional supplements. Feed additives, including protein hydrolysates, emulsifiers, prebiotics, probiotics, feed enzymes, nucleotides, organic acids, phytogenic feed additives, colostrum, and toxin binders, are commonly used in weaned pig diets to promote growth and intestinal health.","type":"text"}]},{"type":"paragraph","content":[{"text":"Dietary supplements are on-farm strategies that take advantage of the synergistic effects of a combination of ingredients that can be administered quickly for targeted support. Some also have the advantage of being water soluble. This is especially helpful In cases where feed intake may be reduced.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Bimulac® Weaner","type":"text","marks":[{"type":"link","attrs":{"href":"/products/bimulac-weaner","uuid":"772e0fa6-e94b-4293-a013-dcba3f76799f","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Bimulac® Pure","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" are two feed supplements that are formulated with ingredients that have been well defined and researched to inhibit and bind pathogens and stimulate the immune system. Specifically tailored to the weaned piglet, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Bimulac® Weaner","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Bimulac® Pure","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" combine ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoSpore®","type":"text","marks":[{"type":"link","attrs":{"href":"/products/technospore","uuid":"ab84c3e0-964b-41f6-b2ee-7fd74be2583e","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"—a unique spore-forming and lactic acid-producing probiotic—and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"TechnoMos®","type":"text","marks":[{"type":"link","attrs":{"href":"/products/technomos","uuid":"b3dda12e-2aa9-4511-820b-433933286824","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"—a yeast cell wall prebiotic with a high content of mannan-oligosaccharides and β-glucans for the best synergy effects of these two ingredients.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Bimulac® Weaner ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"also contains betaine to bring osmotic support, helping to stabilize the intestine around this critical phase. The addition of a fiber-rich polysaccharide to","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" Bimulac® Pure ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"increases the viscosity of the digestive tract, improving fecal consistency and nutrient absorption.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"When a water application is needed, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Zink SL","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Rescue Kit® SL","type":"text","marks":[{"type":"link","attrs":{"href":"/products/rescue-kit-sl","uuid":"af9cac01-28d4-4ea8-af74-79da5b1b7882","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" are two carefully formulated water soluble supplements. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Zink SL","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is a balanced dietary feed supplement of organically bound trace elements in combination with essential vitamins and betaine whereas ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Rescue Kit® SL ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"contains unique, highly effective probiotic strains, betaine, and a blend of organically bound trace minerals. These two supplements stimulate gut immunity and function and help to support healthy intestinal cells and minimize fecal water loss.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Don’t let weaning be a struggle for your piglets. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Bimulac® Weaner","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Bimulac® Pure","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", along with ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Zink SL","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"Rescue Kit® SL","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", offer targeted nutritional support to optimize gut health, boost immunity, and promote healthy growth during this critical transition. Contact us today to learn how our innovative solutions can help you navigate the weaning challenge and unlock the full potential of your piglets.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"_uid":"688b5a9a-14fd-4030-b81a-72171f9acd3d","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"74cd4e8f-6762-4d5b-90e2-619d11b9efa6","title":"Optimizing Weaning Piglet Health: Strategies for a Smooth Transition","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/4560x3420/bfa15afb67/navigating-weaning-challenges-optimizing-piglet-health-and-performance.jpeg","og_title":"Optimizing Weaning Piglet Health: Strategies for a Smooth Transition","description":"Struggling with piglet weaning? Discover the changes that occur at weaning and strategies for a smooth transition and optimal growth.","twitter_image":"https://a.storyblok.com/f/190033/4560x3420/bfa15afb67/navigating-weaning-challenges-optimizing-piglet-health-and-performance.jpeg","twitter_title":"Optimizing Weaning Piglet Health: Strategies for a Smooth Transition","og_description":"Struggling with piglet weaning? Discover the changes that occur at weaning and strategies for a smooth transition and optimal growth.","twitter_description":"Struggling with piglet weaning? Discover the changes that occur at weaning and strategies for a smooth transition and optimal growth."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Weaning can be a make-or-break moment for piglet health and performance. Learn what “gut health” looks like and how the process of weaning affects piglets. Discover how targeted nutritional strategies, including prebiotics, probiotics, and more, can minimize stress, support gut health, and pave the way for a smooth transition and optimal growth.","type":"text"}]}]},"Search_Tags":[],"Published_on":"2025-03-26 00:00","canonical_link":""},"slug":"navigating-weaning-challenges-optimizing-piglet-health-and-performance","full_slug":"news/articles/navigating-weaning-challenges-optimizing-piglet-health-and-performance","sort_by_date":null,"position":-100,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"fed79a1e-030b-40a0-adc9-f3d63d147b54","first_published_at":"2025-03-27T07:39:34.038Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/navigating-weaning-challenges-optimizing-piglet-health-and-performance","translated_slugs":[{"path":"news/articles/herausforderungen-beim-absetzen-meistern-optimierung-von-ferkelgesundheit-und-leistung","name":"Herausforderungen beim Absetzen meistern: Optimierung von Ferkelgesundheit und -leistung.","lang":"de","published":true},{"path":"news/articles/superar-los-retos-del-destete-optimizar-la-salud-y-el-rendimiento-de-los-lechones","name":"Superar los retos del destete: optimizar la salud y el rendimiento de los lechones.","lang":"es","published":true},{"path":"news/articles/enfrentando-os-desafios-do-desmame-otimizando-a-saude-e-o-desempenho-dos-leitoes","name":"Enfrentando os desafios do desmame: otimizando a saúde e o desempenho dos leitões.","lang":"pt-br","published":true}]},{"name":"Heat: A Cow’s Kryptonite.","created_at":"2025-03-24T06:17:51.858Z","published_at":"2025-03-27T07:39:39.759Z","updated_at":"2025-03-27T07:39:39.799Z","id":644206910,"uuid":"00cf2766-9c83-4da4-ab3a-61c7129c6d91","content":{"Tags":[{"_uid":"ced8220d-7430-4ca1-9e6f-d1e25537bc2b","Products":[],"component":"Tags","Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d"],"Feed_Solutions":[]}],"_uid":"93907064-772e-451e-8127-bb3d36e73673","Image":{"id":21492313,"alt":"Heat A Cow’s Kryptonite","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/4884x3482/8df8fbd013/heat-a-cow-s-kryptonite.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"Heat A Cow’s Kryptonite","title":"","source":"","copyright":""},"is_external_url":false},"Title":"Heat: A Cow’s Kryptonite.","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":"language-html"},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"Cows have superpowers. Humans and cows share a long history, with humans relying on these animals for a stable food source. The symbiotic relationship between cows and their ruminal microorganisms is crucial to produce highly nutritious food from poor-quality feed—using plants, stems, and by-products that are unsuitable for other production animals. Consequently, they play a substantial role as a valuable source of food.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"A 4-legged Heating Power Station.","type":"text"}]},{"type":"paragraph","content":[{"text":"The cow is a so-called homeothermic animal. That is, they can maintain their body temperature through metabolic activity. With a constantly active metabolism, cows are excellent feed-to-food converters. However, these superpowers come at a cost; they generate an incredible amount of heat. In an adult cow, this can be almost 1.2 kWh of heat, enough to theoretically heat a small house with the excess heat from three cows. A fact that has been exploited by farmers for centuries.","type":"text"}]},{"type":"paragraph","content":[{"text":"A cow’s metabolism is a complex interplay of microbial activity and physiological efficiency, which generates heat from basal metabolism, activity, digestion, and production. Basal metabolic heat comes from basic cell functions that keep the body alive. It also comes from muscle activity, and from the heat produced by other bodily processes that help with growth, lactation, pregnancy, and the production of proteins or fats.","type":"text"}]},{"type":"paragraph","content":[{"text":"The digestion of feedstuffs also releases heat. At the center of digestion is the rumen—a large-volume anaerobic bioreactor system containing billions of bacteria, protozoa, and fungi—and much of the heat generated is from the intense microbial activity here (Figure 1). Ruminal fermentation generates enough heat to raise the rumen temperature to about 1° C higher than the core body temperature of 38 – 39° C.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21492360,"alt":"Figure 1: The rumen is home to a wide variety of bacterial, fungal, and protozoal species","src":"https://a.storyblok.com/f/190033/3840x2160/1df82172a5/figure-1-the-rumen-is-home-to-a-wide-variety-of-bacterial-fungal-and-protozoal-species.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: The rumen is home to a wide variety of bacterial, fungal, and protozoal species","title":"","source":"","copyright":""}}},{"text":"Figure 1: The rumen is home to a wide variety of bacterial, fungal, and protozoal species. All these make up the rumen microbiome.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"These microorganisms in the rumen break down carbohydrates from the diet fermentation into volatile fatty acids (VFAs) such as acetate, propionate, and butyrate. These VFAs are absorbed through the rumen wall and are used by the cow as a primary source of energy, generating more heat through processing, particularly during gluconeogenesis in the liver. This makes the cow a true “thermal power station on four legs.”","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"When Superpowers Fail.","type":"text"}]},{"type":"paragraph","content":[{"text":"Although a biomechanical masterpiece, the dairy cow is vulnerable to high ambient temperatures. As soon as the temperature rises, her finely tuned balance of heat production and loss is disrupted, and the consequences can be severe. Heat stress—the invisible kryptonite of dairy cows worldwide—has a significant impact on their health, welfare, and production.","type":"text"}]},{"type":"paragraph","content":[{"text":"Thermoregulation is the process of maintaining core body temperature within a narrow range and is thought to optimize organ and system function. Homotherms, such as cows, control the exchange of heat between their body and the environment so that the heat gained from metabolism is balanced by the heat lost to the environment (Figure 2). In this way, body temperature remains stable.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21492359,"alt":"Figure 2: To maintain thermal energy balance","src":"https://a.storyblok.com/f/190033/2880x1400/1a06597e5d/figure-2-to-maintain-thermal-energy-balance.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: To maintain thermal energy balance","title":"","source":"","copyright":""}}},{"text":"Figure 2: To maintain thermal energy balance, heat generated by metabolism (maintenance, activity, growth, lactation, gestation, and feed intake) must be compensated for by heat lost to the environment. This thermal balance cannot be maintained if an animal does not give off enough heat.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"The relationship between core body temperature and the temperature of the environment can be described in terms of several zones that distinguish different physiological responses. The narrowest zone is the thermoneutral zone (TNZ).","type":"text"}]},{"type":"paragraph","content":[{"text":"This zone describes the cow’s comfort zone. Within the thermoneutral zone, they do not need to expend additional energy to keep their body temperature stable: heat production and heat loss are in a harmonious balance.","type":"text"}]},{"type":"paragraph","content":[{"text":"On either side of the TNZ is the temperature range at which heat balance can be achieved, but the metabolic rate or evaporative heat loss will change to maintain balance. In this range, metabolic rate increases at low temperatures and evaporative cooling increases at high temperatures. As such, a homeotherm is under thermal stress whenever it is outside of its TNZ. A dairy cow’s TNZ is between approximately 5 – 20° C (Figure 3) although when lactating, they can withstand lower temperatures.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21492358,"alt":"Figure 3: On either side of the TNZ is the temperature range","src":"https://a.storyblok.com/f/190033/2880x1400/1719b1143c/figure-3-on-either-side-of-the-tnz-is-the-temperature-range.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 3: On either side of the TNZ is the temperature range","title":"","source":"","copyright":""}}},{"text":"Figure 3: On either side of the TNZ is the temperature range at which heat balance can be achieved, but the metabolic rate or evaporative heat loss will change to achieve balance. In this range, metabolic rate increases at low temperatures and evaporative cooling increases at high temperatures, meaning that more energy or more water is required for thermal homeostasis. As such, a homeotherm is under thermal stress whenever it is outside of its TNZ.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Conduction, convection, radiation, and evaporation are just some of the ways cattle can dissipate heat. The difference between a cattle’s body temperature and the ambient temperature determines the success of these techniques and can quickly reach its limits (Figure 4). When the outside temperature rises in combination with high humidity, thermal stress often reaches critical levels as evaporation becomes negligible.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21537366,"alt":"","src":"https://a.storyblok.com/f/190033/2880x1400/643ad8fad7/fig-4-the-severity-of-heat-stress-is-strongly-dependent-on-the-ambient-temperature-and.png","title":"","source":"","copyright":"","meta_data":{}}},{"text":"Figure 4: The severity of heat stress is strongly dependent on the ambient temperature and humidity.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Exposure to temperatures just above TNZ causes an adjustment in heat transfer by increasing blood flow to the skin. This increases the removal of metabolic heat to the periphery where it is lost. However, when the ambient temperature exceeds the skin surface temperature (~ 36° C), heat is transferred from the warmer air to the cooler skin, adding to body heat. To maintain thermal balance, evaporative cooling—through sweating and panting—must increase to match the additional heat load.","type":"text"}]},{"type":"paragraph","content":[{"text":"Unlike more heat tolerant animals like horses, cows only have about 800 sweat glands per cm². As a result, cows sweat inefficiently and rely more on increased respiration for evaporative cooling, increasing from 40 – 60 breaths per minute to over 100 breaths per minute. The onset of panting impacts the cow’s acid/base balance and can lead to respiratory alkalosis. At the same time, water requirements increase dramatically—heat stressed cows have increased water requirements of up to 200 liters per day.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Consequences of heat stress.","type":"text"}]},{"type":"paragraph","content":[{"text":"When heat dissipation is no longer sufficient, physiological adaptation mechanisms kick in. The cow reduces feed intake as microbial fermentation in the rumen generates additional heat leading to a cascade of physiological responses (Figure 5). As blood distribution is diverted to the skin to dissipate heat, blood flow to organs such as the rumen and liver is reduced, further compromising digestive efficiency and metabolic processes. This can lead to reduced energy supply, increased oxidative stress, mobilization of body reserves, hormonal imbalances and reduced milk yield. Immune defenses are also compromised, making animals more susceptible to infection and inflammation.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":21492357,"alt":"Figure 5: Heat stress is a combination of internal and external stimuli","src":"https://a.storyblok.com/f/190033/2880x1400/456d9bcb01/figure-5-heat-stress-is-a-combination-of-internal-and-external-stimuli.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 5: Heat stress is a combination of internal and external stimuli","title":"","source":"","copyright":""}}},{"text":"Figure 5: Heat stress is a combination of internal and external stimuli that works to increase body temperature and produce a physiological reaction.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"The negative effects of heat stress on dairy cattle are well documented. In addition to reduced health and performance, the reproduction and fertility of dairy cows are severely affected, affecting the next generation. The fertility of a dairy cow is influenced by many factors, but environmental factors appear to be the most important.","type":"text"}]},{"type":"paragraph","content":[{"text":"Heat stress can alter estrus duration, uterine function, endocrine status, and follicular growth and development. Prolonged heat stress may also affect early embryonic development and survival, fetal growth, and colostrum quality. In addition, conception rates in dairy cows are negatively affected by extended periods of heat stress, resulting in longer calving intervals.","type":"text"}]},{"type":"paragraph","content":[{"text":"Conception rates in high yielding dairy cows have been declining—often attributed to physiological changes, management changes and increased milk production. However, during periods of heat stress, conception rates decrease even further compared to periods without heat stress. One study found up to a 23% decrease in conception rate for heat stressed cows compared to non-heat stressed cows, and another found that body temperatures > 39.1° C caused conception rates to drop from 21% to 15%. Finally, a third study found that exposure to heat stress 3 weeks prior to artificial insemination can negatively affect conception rates. Only in the TNZ can dairy cows reach their full genetic potential at the lowest physiological cost and highest productivity.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Counteracting the Effects of a Cow’s Kryptonite.","type":"text"}]},{"type":"paragraph","content":[{"text":"There are several different approaches to significantly reduce the pressure of heat stress on cows. They all have the same goal: how can I get my herd to suffer fewer losses and less health stress during hot periods? These approaches range from housing conditions, such as the correct placement, orientation, and strength of fans and spray systems, to management with adapted feeding times, to our specialty: feed technology.","type":"text"}]},{"type":"paragraph","content":[{"text":"We are researching innovative approaches, including the use of phytogenic additives, to support the cow’s natural metabolic processes and sustainably reduce heat stress. Our results so far are very promising—stay tuned for this exciting new solution. Let’s take on this challenge together!","type":"text"}]}]},"_uid":"247e60d5-7757-4979-8bfa-0775cd6a38c3","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"fe04cd37-19d2-43ac-98bf-10f3a413ab30","title":"Cows’ Thermal Superpowers: The Heat, the Stress, the Solutions","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/4884x3482/8df8fbd013/heat-a-cow-s-kryptonite.jpeg","og_title":"Cows’ Thermal Superpowers: The Heat, the Stress, the Solutions","description":"Discover how cows turn poor-quality feed into valuable food, generate heat in the process, and what happens when the heat gets too much.","twitter_image":"https://a.storyblok.com/f/190033/4884x3482/8df8fbd013/heat-a-cow-s-kryptonite.jpeg","twitter_title":"Cows’ Thermal Superpowers: The Heat, the Stress, the Solutions","og_description":"Discover how cows turn poor-quality feed into valuable food, generate heat in the process, and what happens when the heat gets too much.","twitter_description":"Discover how cows turn poor-quality feed into valuable food, generate heat in the process, and what happens when the heat gets too much."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Did you know three cows can generate enough heat to warm a small house? Their superpowers come from a unique partnership with ruminal microbes, allowing them to transform poor-quality feed into highly nutritious food. But like any superhero, cows have a vulnerability: heat stress. Explore how these living “thermal power stations” maintain their body temperature—and what happens when scorching temperatures tip the balance.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"Search_Tags":[],"Published_on":"2025-03-26 00:00","canonical_link":""},"slug":"heat-a-cow-s-kryptonite","full_slug":"news/articles/heat-a-cow-s-kryptonite","sort_by_date":null,"position":-90,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"85b1f2f3-bb30-4509-b3af-53bf79d4cc5c","first_published_at":"2025-03-27T07:39:39.759Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/heat-a-cow-s-kryptonite","translated_slugs":[{"path":"news/articles/hitze-das-kryptonit-der-kuh","name":"Hitze - Das Kryptonit der Kuh.","lang":"de","published":true},{"path":"news/articles/calor-la-kriptonita-de-las-vacas","name":"Calor: la kriptonita de las vacas.","lang":"es","published":true},{"path":"news/articles/calor-a-kryptonita-de-uma-vaca","name":"Calor: A kryptonita de uma vaca.","lang":"pt-br","published":true}]},{"name":"The Irreplaceable Nutrient","created_at":"2025-01-27T09:21:20.406Z","published_at":"2025-01-30T10:35:49.556Z","updated_at":"2025-01-30T10:35:49.627Z","id":615271946,"uuid":"4e0a81e8-2182-4b09-8661-977098ae54de","content":{"Tags":[{"_uid":"c0797583-4d11-4153-8683-05e7d460dd27","Products":[],"component":"Tags","Animal_Species":["888ff53a-18a3-46b2-8333-ff560e35e5a1"],"Feed_Solutions":[]}],"_uid":"8be4491e-5c9c-4ee5-80a9-c981ac6b2ae5","Image":{"id":20182590,"alt":"The Irreplaceable Nutrient","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/2541x1588/b66dbbcd89/the-irreplaceable-nutrient.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"The Irreplaceable Nutrient","title":"","source":"","copyright":""},"is_external_url":false},"Title":"The Irreplaceable Nutrient","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":null},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"Water: More than just refreshing; it’s the very essence of life. Often called the “elixir of life,” water’s vital role in sustaining life is undeniable.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"While most animals can go weeks without food, survival without water is limited to a few days at most, underscoring its crucial status as the most important of all nutrients.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Reading the Signs: Water as a Health Indicator","type":"text"}]},{"type":"paragraph","content":[{"text":"Water is involved in several essential metabolic functions (Figure 1). For example, it is essential for the osmotic balance of cells, transporting nutrients and removing harmful substances from the body, and regulating body temperature and digestion, to name but a few. In general, birds consume about twice as much water as feed, but this depends on several factors such as:","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"bullet_list","content":[{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"temperature","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"humidity","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"stocking density","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"breed, age","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},{"type":"list_item","content":[{"type":"paragraph","content":[{"text":"weight","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20182901,"alt":"Figure 1: Water has many essential functions in the body","src":"https://a.storyblok.com/f/190033/2880x732/85b1d3eaf7/figure-1-water-has-many-essential-functions-in-the-body.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: Water has many essential functions in the body","title":"","source":"","copyright":""}}},{"text":"Figure 1: Water has many essential functions in the body.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"As water is fundamental to many metabolic functions, water consumption can be used as an indication that the birds are not feeling well or that something is wrong—even before the first signs of illness are seen. For example, reduced water intake can be a sign that the house temperature is too low or of a possible disease outbreak (such as coccidiosis).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Increased water intake can often be a sign of an impending outbreak of an inflammatory disease, or that the temperature is too high, leading to thermal stress. Under thermal stress from heat, birds will drink more to cool themselves if the water is colder than their body temperature. Thus, water intake can be viewed as an early warning system for poultry, and changes in water intake can be a sign of an impending problem.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Water-Based Supplementation","type":"text"}]},{"type":"paragraph","content":[{"text":"Poultry needs support during periods of stress or disease. One way to provide support is through medicated feed additives (pain relievers, antibiotics, etc.). Drinking water supplementation can also be an effective way to support birds during critical periods. The decision to use one or the other depends on the urgency of the problem. Feed additives are a valuable choice to provide the stable foundation needed for optimal growth and performance. However, it is difficult to address sudden changes in a bird’s needs with feed additives.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Drinking water supplements are uniquely positioned for spontaneous use in urgent situations. Often used in high doses for short periods of time, they are used as an adjunct to treatment and in addition to feed additives to provide short-term support in critical situations. Water is an ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"efficient and ","type":"text"},{"text":"effective delivery vehicle for","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text"},{"text":"water-soluble medicaments and supplements","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":".","type":"text"}]},{"type":"paragraph","content":[{"text":"For one, water treatments can reduce overall handling stress, such as during vaccinations, but it is also an excellent medium for treatments or support during illness when handling is difficult or when in-feed treatments are ineffective due to reduced feed intake. In addition, stressed or sick animals often reduce or stop eating but continue to drink water, making in-feed treatments ineffective but water support highly successful.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The use of additives in the water gives the farmer full control over their use. This means that the type, dosage, and duration can be adjusted to best meet the needs of the animals. In addition, the supplement can be applied immediately, bypassing the longer ordering, manufacturing and delivery times required for an in-feed application. This provides excellent flexibility in terms of treatment types, schedules, and duration.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Water Quality: A Foundation for Health","type":"text"}]},{"type":"paragraph","content":[{"text":"Clean, quality water is the foundation of good animal husbandry. Several factors influence poultry’s acceptance of water; in fact, the taste of the water has a major impact. Poultry can detect basic tastes—salty, sweet, bitter, and sour—but are more sensitive to bitter flavors, which may help them avoid potentially toxic substances. Moreover, they prefer slightly acidic tasting water and, while not necessarily rejecting alkaline water, will reduce water intake when water pH rises above 8. Water from different regions and sources can vary in quality and characteristics—such as high levels of trace minerals—which can negatively affect taste.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20182952,"alt":"Figure g: The Irreplaceable Nutrient","src":"https://a.storyblok.com/f/190033/2880x1400/d61d439cab/figure-g-the-irreplaceable-nutrient.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure g: The Irreplaceable Nutrient","title":"","source":"","copyright":""}}},{"text":"In addition to taste, water quality is critical and requires regular monitoring of pH level, mineral content, and microbial contamination. Another important but difficult factor to manage is water temperature as cool water improves water intake in warm temperatures and helps to minimize biofilm development. This is especially important when adding supplements to the water line.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Some ways to provide cool water include insulating water lines and reservoirs, placing watering devices in covered or shaded areas, refilling water containers with cool, fresh water throughout the day, and increasing the size of water containers. In extreme heat, it may be necessary to install cooling systems to cool the air around the watering system.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The quality, condition, and design of an irrigation system can also affect biofilm development. Increased water pressure and constant flow can help prevent biofilm development compared to low flow or stagnant water, dry lines, and dead ends. Stainless steel piping is more resistant to biofilm buildup than plastic components, which can become porous or cracked, providing the ideal surface for biofilm attachment.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"A biofilm’s nutrient supply largely depends on the quality of the water and any supplements added. The levels of Ca","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"2+","type":"text","marks":[{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and Fe","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"2+","type":"text","marks":[{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" ions also play an important role, as they can be metabolized by certain bacteria or used as structures for attachment. These ions may also affect the function of the watering system resulting in decreased water intake and poor performance. Added nutrients, minerals, and probiotics that benefit the animals may also benefit the microorganisms in the biofilm.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"General water quality standards, including ideal mineral levels, are readily available on the Internet. A particularly useful overview has been published on ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"The Poultrysite by Dr. S. Watkins","type":"text","marks":[{"type":"link","attrs":{"href":"https://www.thepoultrysite.com/articles/water-identifying-and-correcting-challenges","uuid":null,"anchor":null,"custom":{},"target":"_blank","linktype":"url"}},{"type":"textStyle","attrs":{"color":""}}]},{"text":", a leading expert in evaluating and improving drinking water quality for livestock production.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Water Line Hygiene: A Crucial Component","type":"text"}]},{"type":"paragraph","content":[{"text":"When administering supplements or medications in drinking water, water line hygiene is key. Ultimately, the goal is to keep the lines free of non-beneficial microbes, an often-elusive task. Flushing the lines regularly—daily, at best—is the simplest method of improving water line hygiene. This removes old, warm water, and microbes. Daily flushing is especially important during the first few days of housing, when temperatures are high, and water intake is low. In addition, flushing the lines after each supplement water application will help remove any residue.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Disinfecting and cleaning the lines both during and between cycles is another important aspect of water hygiene. After each cycle, the ","type":"text"},{"text":"water system should be cleaned and disinfected with the same thoroughness ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"as","type":"text"},{"text":" the rest of the house","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" using a cleaning agent that can remove any biofilm that may have accumulated","type":"text"},{"text":".","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text"},{"text":"Cleaning agents can be acids, bases, hydrogen-peroxide","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":",","type":"text"},{"text":" or chlorine","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":", which","type":"text"},{"text":" can","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" also ","type":"text"},{"text":"reduce the ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"number","type":"text"},{"text":" of microbes in the water lines (figure 2).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20182900,"alt":"Figure 2: Disinfecting water can be accomplished with several types of disinfectants including chlorine dioxide","src":"https://a.storyblok.com/f/190033/2880x1400/4917fd11b1/figure-2-disinfecting-water-can-be-accomplished-with-several-types-of-disinfectants-including-chlorine-dioxide.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: Disinfecting water can be accomplished with several types of disinfectants including chlorine dioxide","title":"","source":"","copyright":""}}},{"text":"Figure 2: Disinfecting water can be accomplished with several types of disinfectants including chlorine dioxide, hydrogen peroxide, and peracetic acid. Refer to local guidelines and regulations.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"It is important to follow the local regulations for the categories of cleaners and disinfectants that can be used for different situations. For example, the EU Biocidal Products Regulation categorizes biocidal products based on their intended use.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The PT5 category of disinfectants is used to disinfect drinking water for humans and animals, including poultry, and includes chlorine dioxide, hydrogen peroxide, and peracetic acid. Essential for preventing contamination and ensuring food safety, PT4 disinfectants are used to keep surfaces and equipment that come into contact with food and feed free of harmful pathogens. Examples include formaldehyde, glutaraldehyde, and sodium hypochlorite. As each type and method has its own advantages and considerations, it is important to choose one that best fits the specific needs and complies with local regulations.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Elevate Your Water Management","type":"text"}]},{"type":"paragraph","content":[{"text":"As water is the lifeblood of any flock, clean and properly managed waterlines provide the foundation for robust health, efficient nutrient utilization, and timely responses to emerging challenges. By continuously monitoring water quality, maintaining sanitary distribution systems, and incorporating water-based supplements and medications, producers can ensure their birds thrive in ever-changing conditions.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Now is the time to elevate your water management practices—evaluate your water lines, invest in proper sanitation protocols, and adopt flexible supplementation strategies. In doing so, you will unlock the full potential of your birds and set the stage for more resilient, productive, and profitable poultry operations. For more information on nutrient supplementation through drinking water, please contact your expert Biochem representative.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"_uid":"f789e379-1cfd-4b6e-aed3-898e6ae835dd","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"c64e50ca-89a9-4021-8c4c-4c6ac049287c","title":"Water: The Key to Poultry Success","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/2541x1588/b66dbbcd89/the-irreplaceable-nutrient.jpeg","og_title":"Water: The Key to Poultry Success","description":"Water is essential for poultry health. Learn how to optimize water management, improve water quality, and leverage water-based supplementation to enhance bird performance and resilience.","twitter_image":"https://a.storyblok.com/f/190033/2541x1588/b66dbbcd89/the-irreplaceable-nutrient.jpeg","twitter_title":"Water: The Key to Poultry Success","og_description":"Water is essential for poultry health. Learn how to optimize water management, improve water quality, and leverage water-based supplementation to enhance bird performance and resilience.","twitter_description":"Water is essential for poultry health. Learn how to optimize water management, improve water quality, and leverage water-based supplementation to enhance bird performance and resilience."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Water, often overlooked, is a critical nutrient for poultry health and performance. Discover how optimizing water management and supplementation can elevate your bird’s well-being and productivity.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"Search_Tags":[],"Published_on":"2025-01-29 00:00","canonical_link":""},"slug":"the-irreplaceable-nutrient","full_slug":"news/articles/the-irreplaceable-nutrient","sort_by_date":null,"position":-80,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"3e6fe123-0269-4f25-9b96-868b961c3106","first_published_at":"2025-01-29T07:09:13.535Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/the-irreplaceable-nutrient","translated_slugs":[{"path":"news/articles/der-unersetzbare-naehrstoff","name":"Der unersetzbare Nährstoff","lang":"de","published":true},{"path":"news/articles/el-nutriente-irremplazable","name":"El nutriente irremplazable","lang":"es","published":true},{"path":"news/articles/o-nutriente-insubstituivel","name":"O nutriente insubstituível","lang":"pt-br","published":true}]},{"name":"Battling Mycotoxins: Unlocking Dairy Performance with B.I.O.Tox® Activ8","created_at":"2025-01-27T08:14:23.619Z","published_at":"2025-01-29T07:09:13.871Z","updated_at":"2025-01-29T07:09:13.951Z","id":615247945,"uuid":"90300bbf-989a-46e7-a784-1c40fc5f9c0e","content":{"Tags":[{"_uid":"c0797583-4d11-4153-8683-05e7d460dd27","Products":["e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","45bf1a90-a3c2-46f4-9a41-e8963e411941","14611b48-2ed1-414d-a2f3-4076014a0be0","aacc42ff-bd44-41b6-a7ca-dc3e5eba3fc5"],"component":"Tags","Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","888ff53a-18a3-46b2-8333-ff560e35e5a1","fd1eeff1-3fec-434c-8cbc-39e38f966007","55d3b968-2ba6-474c-8926-7cf0e779b6e0"],"Feed_Solutions":["6b994c69-a560-4fc5-9942-3a00876716f2","abc9dcbc-1d46-4635-b3a9-26b833e011c1","0b70fc3f-fc3f-4201-84a5-be656f27c716","86957ee5-17c1-4614-b390-4ff76652d072","00925c7f-584a-4ca8-9180-967d87cf7261","f337bfba-c22d-4500-aea9-71cd3355246c"]}],"_uid":"8be4491e-5c9c-4ee5-80a9-c981ac6b2ae5","Image":{"id":20181325,"alt":"Battling Mycotoxins - Unlocking Dairy Performance with BIOTox® Activ8","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/8256x5504/cc698f6405/battling-mycotoxins-unlocking-dairy-performance-with-biotox-activ8.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"Battling Mycotoxins - Unlocking Dairy Performance with BIOTox® Activ8","title":"","source":"","copyright":""},"is_external_url":false},"Title":"Battling Mycotoxins: Unlocking Dairy Performance with B.I.O.Tox® Activ8","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":null},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"Mycotoxins are naturally occurring toxic secondary metabolites produced by fungi (molds) that can have a wide range of adverse effects, including liver and kidney toxicity, central nervous system effects, and estrogenic effects, to name just a few. Mycotoxins can contaminate a wide range of feed raw materials, compromising animal welfare, reducing animal performance, and affecting the sustainability and profitability of the entire value chain. The industry-important mycotoxins include aflatoxins, zearalenone, trichothecenes, fumonisins, ochratoxin A, and the ergot alkaloids.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Hidden Threats in Silage: Unveiling Mycotoxin Contamination","type":"text"}]},{"type":"paragraph","content":[{"text":"Mycotoxins occur in a range of livestock feeds, including concentrates, forages, hay, and silage. A survey of the global occurrence of mycotoxins found that 81 % of feed samples collected in the Americas, Europe, and Asia were positive for at least one mycotoxin.","type":"text"}]},{"type":"paragraph","content":[{"text":"A review of the literature shows that the contribution of silage, a major component of the dairy cow diet, to the total amount of mycotoxins ingested by cows can be significant. Indeed, silage was responsible for approximately 3 times more mycotoxin ingestion by dairy cows than other feed ingredients in a study of ensiled forages on 24 farms in the Netherlands.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"DON in Dairy: The Silent Saboteur Affecting Herd Health","type":"text"}]},{"type":"paragraph","content":[{"text":"Deoxynivalenol (DON) is a Fusarium produced mycotoxin that is commonly detected in feed. It is also called vomitoxin as it is associated with vomiting in swine and dogs. Among the livestock species, ruminants appear to be less sensitive to the effects of DON because of ruminal microbial degradation.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"However, additional metabolic burdens on ruminal microbes like concentrate-rich diets, faster rumen turnover rates, reduced pH, or high dietary DON levels, may restrict the ruminal detoxification capacity in high-yielding dairy cows. Under these conditions, DON exposure may cause problems comparable to those seen in monogastric animals.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The influence of (DON) on health and performance parameters of dairy cows has been widely reported. In short, DON shifts rumen microbial composition, alters rumen metabolism of unsaturated fatty acids and amino acids, and increases the risk of oxidative stress, inflammation, and reduced immune responses in dairy cows, leading to a wide range of symptoms such as decreased milk yield, altered milk quality, or an increase of metabolic and infectious diseases (Figure 1).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181781,"alt":"Figure 1: The effects of DON exposure to the health and productivity of dairy cows","src":"https://a.storyblok.com/f/190033/2880x1486/08f6b95543/figure-1-the-effects-of-don-exposure-to-the-health-and-productivity-of-dairy-cows.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: The effects of DON exposure to the health and productivity of dairy cows","title":"","source":"","copyright":""}}},{"text":"Figure 1: The effects of DON exposure to the health and productivity of dairy cows.","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"A survey of feed samples showed that DON is a common threat to livestock with a prevalence of 59 %. Another survey on the presence of mycotoxins in ensiled feed in the Netherlands found maize and wheat silage to be the main sources of DON in dairy cattle diets, and in Poland a multi-year mycotoxin survey found DON in 86 % of 143 maize silage samples.","type":"text"}]},{"type":"paragraph","content":[{"text":"These studies show, among other things, that DON is one of the most frequently detected mycotoxins in both feed and silage. As such, strategies aimed at preventing increased absorption of DON are essential for animal health and operational efficiency.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Comprehensive Mycotoxin Management: Beyond Simple Solutions","type":"text"}]},{"type":"paragraph","content":[{"text":"Comprehensive mycotoxin management is needed for effective mycotoxin control. This involves agricultural measures that should be considered before, during, and after the harvest. Toxin binders are another part of a complete toxin management strategy. Toxin binders are feed additives that can help to significantly reduce the bioavailability of mycotoxins. The","type":"text"},{"text":"y","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" work by irreversibly binding mycotoxins, allowing for excretion in the feces. Although the concept is simple, in practice, this becomes a bit more complex.","type":"text"}]},{"type":"paragraph","content":[{"text":"For one, the different mycotoxins vary considerably in their physical and chemical properties and a good binder surface must meet these criteria to be as effective as possible. Moreover, the binder must retain these properties under the widely varying pH changes along the gastrointestinal tract, which also can influence the surface structure of the toxin binder. In essence, the goal is a binding component that stably binds all relevant mycotoxins in the intestinal tract at all pH levels.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Field Trial Success Story: B.I.O.Tox® Activ8 Boosts Dairy Performance","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The effectiveness of adding a toxin binder to the TMR was tested in a field trial on a German dairy farm with approximately 1,180 lactating cows. Farm production data showed a clear negative tendency from spring onwards, reaching a low point in June. Mycotoxins had been detected in the milk and in the TMR. Therefore, a toxin binder (","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"link","attrs":{"href":"/products/biotox-activ8","uuid":"e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":") was added to the diet of lactating cows for a period of two months, during which milk mycotoxin levels, performance, and health parameters were monitored.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The trial was conducted in an on-off design from 8 July to 10 September. Lactating cows were fed diets corresponding to their stage of lactation (start or high yield) with ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" (20 g/head/day in the start group and 25 g/head/day in the high yield group) added as a premix to the TMR.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The TMR was analyzed for mycotoxins before the start of the study and at the end of the study. The test revealed the presence of DON and zearalenone (ZEA), indicating a continuous, natural contamination of these two mycotoxins during the trial period (Figure 2A, B).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181779,"alt":"Figure 2: DON and ZEA contamination levels in the TMR before trial start and at the end of the trial","src":"https://a.storyblok.com/f/190033/2880x1600/b06c4ab906/figure-2-don-and-zea-contamination-levels-in-the-tmr-before-trial-start-and-at-the-end-of-the-trial.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: DON and ZEA contamination levels in the TMR before trial start and at the end of the trial","title":"","source":"","copyright":""}}},{"text":"Figure 2: DON and ZEA contamination levels in the TMR before trial start and at the end of the trial.","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Moreover, DON was noted in milk samples at a level of 70 µg/L before the start of the trial. The addition of ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"link","attrs":{"href":"/products/biotox-activ8","uuid":"e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" to the diet resulted in a stark reduction in DON milk levels at the end of the trial (70 µg/L to 17.3 µg/L; Figure 3). The clear reduction of DON-derivates in the milk in the face of constant mycotoxin contamination in the TMR underscores the efficiency of ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" in reducing DON’s bioavailability.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181780,"alt":"Figure 3: DON contamination levels in the milk before trial start and at the end of the trial","src":"https://a.storyblok.com/f/190033/2880x1600/8ac276c8a3/figure-3-don-contamination-levels-in-the-milk-before-trial-start-and-at-the-end-of-the-trial.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 3: DON contamination levels in the milk before trial start and at the end of the trial","title":"","source":"","copyright":""}}},{"text":"Figure 3: DON contamination levels in the milk before trial start and at the end of the trial.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Compared to the previous nine-month average, the June (pre-trial) milk yield was down 12.9 % (Figure 4A). In addition, milk fat in tank milk had decreased significantly in June compared to the previous month (Figure 4B). By the end of the trial, milk yield had increased by 8 % compared to June and milk fat in tank milk had increased dramatically to levels greater than before the trial (Figure 4B).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181778,"alt":"Figure 4: Official testing milking averages before and during the trial (A)","src":"https://a.storyblok.com/f/190033/2880x1600/58bad1ad4a/figure-4-official-testing-milking-averages-before-and-during-the-trial-a.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 4: Official testing milking averages before and during the trial (A)","title":"","source":"","copyright":""}}},{"text":"Figure 4: Official testing milking averages before and during the trial (A), Percentage milk fat in tank milk for the two months preceding the trial and during the trial (B).","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"In addition, compared to the preceding nine-month average, the SSC had increased from 328 (x 1000/mL) to 475 (x 1000/mL) in June. After the addition of ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" during the trial period, the SCC was reduced to near baseline levels of 390 (x 1000/mL) in September (data not shown). Blood serum measurements of liver enzymes showed improved liver health at the end of the trial (data not shown).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"B.I.O.Tox® Activ8: Your Holistic Solution for Mycotoxin Control","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"link","attrs":{"href":"/products/biotox-activ8","uuid":"e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"’s supreme binding capabilities make it highly effective against all major mycotoxins, including aflatoxins, ochratoxins, zearalenone, T-2/HT2-toxin, DON, and fumonisins. However, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8 ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"is more than just a mycotoxin binder; it also contains natural detoxifiers that support the liver’s antioxidative and detoxifying processes. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8 ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"helps to prevent or counteract the damage caused by mycotoxins and improves overall performance.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"B.I.O.Tox®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"bold"},{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is a reliable and scientifically supported solution to mycotoxin contamination in animal feed. Its combination of supreme binding capabilities and natural detoxifiers makes it a holistic solution for improving animal health and performance as well as protecting human safety.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is your solution for fast and efficient mycotoxin control!","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"_uid":"f789e379-1cfd-4b6e-aed3-898e6ae835dd","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"c64e50ca-89a9-4021-8c4c-4c6ac049287c","title":"B.I.O.Tox® Activ8: Combat Mycotoxins to Boost Dairy Cow Health & Yield","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/8256x5504/cc698f6405/battling-mycotoxins-unlocking-dairy-performance-with-biotox-activ8.jpeg","og_title":"B.I.O.Tox® Activ8: Combat Mycotoxins to Boost Dairy Cow Health & Yield","description":"Discover how B.I.O.Tox® Activ8 combats mycotoxins like DON in dairy feed, enhancing cow health and boosting milk yield. Learn about effective mycotoxin management.","twitter_image":"https://a.storyblok.com/f/190033/8256x5504/cc698f6405/battling-mycotoxins-unlocking-dairy-performance-with-biotox-activ8.jpeg","twitter_title":"B.I.O.Tox® Activ8: Combat Mycotoxins to Boost Dairy Cow Health & Yield","og_description":"Discover how B.I.O.Tox® Activ8 combats mycotoxins like DON in dairy feed, enhancing cow health and boosting milk yield. Learn about effective mycotoxin management.","twitter_description":"Discover how B.I.O.Tox® Activ8 combats mycotoxins like DON in dairy feed, enhancing cow health and boosting milk yield. Learn about effective mycotoxin management."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Hidden toxins in your dairy feed could be sabotaging your herd’s health and productivity. Mycotoxins like deoxynivalenol (DON) are common contaminants in silage, posing significant risks to dairy cows, including decreased milk yield and health issues. Discover how ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", a powerful toxin binder, effectively reduces mycotoxin bioavailability, boosts milk production, and enhances overall herd health. Learn about a real-world success story where ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" made a remarkable difference.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"Search_Tags":[],"Published_on":"2025-01-29 00:00","canonical_link":""},"slug":"battling-mycotoxins-unlocking-dairy-performance-with-b-i-o-tox-activ8","full_slug":"news/articles/battling-mycotoxins-unlocking-dairy-performance-with-b-i-o-tox-activ8","sort_by_date":null,"position":-70,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"e26be2b6-0193-4057-b60b-0a00caf65e21","first_published_at":"2025-01-29T07:09:13.871Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/battling-mycotoxins-unlocking-dairy-performance-with-b-i-o-tox-activ8","translated_slugs":[{"path":"news/articles/mykotoxinbekaempfung-bewahrung-der-milchleistung-mit-b-i-o-tox-activ8","name":"Mykotoxinbekämpfung: Bewahrung der Milchleistung mit B.I.O.Tox® Activ8","lang":"de","published":true},{"path":"news/articles/combatiendo-las-micotoxinas-aumenta-el-rendimiento-lechero-con-b-i-o-tox-activ8","name":"Combatiendo las micotoxinas: aumenta el rendimiento lechero con B.I.O.Tox® Activ8.","lang":"es","published":true},{"path":"news/articles/combatendo-as-micotoxinas-liberando-o-desempenho-dos-laticinios-com-o-b-i-o-tox-activ8","name":"Combatendo as micotoxinas: Liberando o desempenho dos laticínios com o B.I.O.Tox® Activ8","lang":"pt-br","published":true}]}],"isBgGrey":true,"component":"Articles_Section","Description":"From scientific insights to innovative solutions, our collection of thought-provoking articles offers valuable insights."},{"_uid":"f2a4da9e-272c-4a1e-a8f6-4687f8f1aeca","Button":[{"Icon":[],"Name":"Subscribe Now","_uid":"174ca2d3-6169-42ba-ac19-997fd163a00e","data_Id":"","component":"Button"}],"Heading":"Subscribe to Our Newsletter.","component":"Newsletter_Section_Button","Description":"Stay in the loop! Get educational insights and product news delivered right to your inbox. Sign up for our quarterly newsletter today! *Indicates a required field."}],"no_index":false,"component":"page","meta_tags":{"_uid":"60069d35-1eec-4e01-af52-4896cb2e5bc9","title":"","plugin":"seo_metatags","og_image":"","og_title":"","description":"","twitter_image":"","twitter_title":"","og_description":"","twitter_description":""},"canonical_link":""},"addPlainHero":false}]