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","type":"text"}]},{"type":"paragraph","content":[{"text":"Water: More than just refreshing; it’s the very essence of life. Often called the “elixir of life,” water’s vital role in sustaining life is undeniable.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"While most animals can go weeks without food, survival without water is limited to a few days at most, underscoring its crucial status as the most important of all nutrients.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Reading the Signs: Water as a Health Indicator","type":"text"}]},{"type":"paragraph","content":[{"text":"Water is involved in several essential metabolic functions (Figure 1). For example, it is essential for the osmotic balance of cells, transporting nutrients and removing harmful substances from the body, and regulating body temperature and digestion, to name but a few. 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For example, reduced water intake can be a sign that the house temperature is too low or of a possible disease outbreak (such as coccidiosis).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Increased water intake can often be a sign of an impending outbreak of an inflammatory disease, or that the temperature is too high, leading to thermal stress. Under thermal stress from heat, birds will drink more to cool themselves if the water is colder than their body temperature. Thus, water intake can be viewed as an early warning system for poultry, and changes in water intake can be a sign of an impending problem.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Water-Based Supplementation","type":"text"}]},{"type":"paragraph","content":[{"text":"Poultry needs support during periods of stress or disease. One way to provide support is through medicated feed additives (pain relievers, antibiotics, etc.). Drinking water supplementation can also be an effective way to support birds during critical periods. The decision to use one or the other depends on the urgency of the problem. Feed additives are a valuable choice to provide the stable foundation needed for optimal growth and performance. However, it is difficult to address sudden changes in a bird’s needs with feed additives.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Drinking water supplements are uniquely positioned for spontaneous use in urgent situations. Often used in high doses for short periods of time, they are used as an adjunct to treatment and in addition to feed additives to provide short-term support in critical situations. 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In addition, stressed or sick animals often reduce or stop eating but continue to drink water, making in-feed treatments ineffective but water support highly successful.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The use of additives in the water gives the farmer full control over their use. This means that the type, dosage, and duration can be adjusted to best meet the needs of the animals. In addition, the supplement can be applied immediately, bypassing the longer ordering, manufacturing and delivery times required for an in-feed application. This provides excellent flexibility in terms of treatment types, schedules, and duration.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Water Quality: A Foundation for Health","type":"text"}]},{"type":"paragraph","content":[{"text":"Clean, quality water is the foundation of good animal husbandry. Several factors influence poultry’s acceptance of water; in fact, the taste of the water has a major impact. Poultry can detect basic tastes—salty, sweet, bitter, and sour—but are more sensitive to bitter flavors, which may help them avoid potentially toxic substances. Moreover, they prefer slightly acidic tasting water and, while not necessarily rejecting alkaline water, will reduce water intake when water pH rises above 8. Water from different regions and sources can vary in quality and characteristics—such as high levels of trace minerals—which can negatively affect taste.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20182952,"alt":"Figure g: The Irreplaceable Nutrient","src":"https://a.storyblok.com/f/190033/2880x1400/d61d439cab/figure-g-the-irreplaceable-nutrient.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure g: The Irreplaceable Nutrient","title":"","source":"","copyright":""}}},{"text":"In addition to taste, water quality is critical and requires regular monitoring of pH level, mineral content, and microbial contamination. Another important but difficult factor to manage is water temperature as cool water improves water intake in warm temperatures and helps to minimize biofilm development. This is especially important when adding supplements to the water line.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Some ways to provide cool water include insulating water lines and reservoirs, placing watering devices in covered or shaded areas, refilling water containers with cool, fresh water throughout the day, and increasing the size of water containers. In extreme heat, it may be necessary to install cooling systems to cool the air around the watering system.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The quality, condition, and design of an irrigation system can also affect biofilm development. Increased water pressure and constant flow can help prevent biofilm development compared to low flow or stagnant water, dry lines, and dead ends. Stainless steel piping is more resistant to biofilm buildup than plastic components, which can become porous or cracked, providing the ideal surface for biofilm attachment.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"A biofilm’s nutrient supply largely depends on the quality of the water and any supplements added. The levels of Ca","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"2+","type":"text","marks":[{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" and Fe","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"2+","type":"text","marks":[{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" ions also play an important role, as they can be metabolized by certain bacteria or used as structures for attachment. These ions may also affect the function of the watering system resulting in decreased water intake and poor performance. Added nutrients, minerals, and probiotics that benefit the animals may also benefit the microorganisms in the biofilm.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"General water quality standards, including ideal mineral levels, are readily available on the Internet. A particularly useful overview has been published on ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"The Poultrysite by Dr. S. Watkins","type":"text","marks":[{"type":"link","attrs":{"href":"https://www.thepoultrysite.com/articles/water-identifying-and-correcting-challenges","uuid":null,"anchor":null,"custom":{},"target":"_blank","linktype":"url"}},{"type":"textStyle","attrs":{"color":""}}]},{"text":", a leading expert in evaluating and improving drinking water quality for livestock production.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Water Line Hygiene: A Crucial Component","type":"text"}]},{"type":"paragraph","content":[{"text":"When administering supplements or medications in drinking water, water line hygiene is key. Ultimately, the goal is to keep the lines free of non-beneficial microbes, an often-elusive task. Flushing the lines regularly—daily, at best—is the simplest method of improving water line hygiene. This removes old, warm water, and microbes. Daily flushing is especially important during the first few days of housing, when temperatures are high, and water intake is low. In addition, flushing the lines after each supplement water application will help remove any residue.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Disinfecting and cleaning the lines both during and between cycles is another important aspect of water hygiene. After each cycle, the ","type":"text"},{"text":"water system should be cleaned and disinfected with the same thoroughness ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"as","type":"text"},{"text":" the rest of the house","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" using a cleaning agent that can remove any biofilm that may have accumulated","type":"text"},{"text":".","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text"},{"text":"Cleaning agents can be acids, bases, hydrogen-peroxide","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":",","type":"text"},{"text":" or chlorine","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":", which","type":"text"},{"text":" can","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" also ","type":"text"},{"text":"reduce the ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"number","type":"text"},{"text":" of microbes in the water lines (figure 2).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20182900,"alt":"Figure 2: Disinfecting water can be accomplished with several types of disinfectants including chlorine dioxide","src":"https://a.storyblok.com/f/190033/2880x1400/4917fd11b1/figure-2-disinfecting-water-can-be-accomplished-with-several-types-of-disinfectants-including-chlorine-dioxide.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: Disinfecting water can be accomplished with several types of disinfectants including chlorine dioxide","title":"","source":"","copyright":""}}},{"text":"Figure 2: Disinfecting water can be accomplished with several types of disinfectants including chlorine dioxide, hydrogen peroxide, and peracetic acid. Refer to local guidelines and regulations.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"It is important to follow the local regulations for the categories of cleaners and disinfectants that can be used for different situations. For example, the EU Biocidal Products Regulation categorizes biocidal products based on their intended use.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The PT5 category of disinfectants is used to disinfect drinking water for humans and animals, including poultry, and includes chlorine dioxide, hydrogen peroxide, and peracetic acid. Essential for preventing contamination and ensuring food safety, PT4 disinfectants are used to keep surfaces and equipment that come into contact with food and feed free of harmful pathogens. Examples include formaldehyde, glutaraldehyde, and sodium hypochlorite. As each type and method has its own advantages and considerations, it is important to choose one that best fits the specific needs and complies with local regulations.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Elevate Your Water Management","type":"text"}]},{"type":"paragraph","content":[{"text":"As water is the lifeblood of any flock, clean and properly managed waterlines provide the foundation for robust health, efficient nutrient utilization, and timely responses to emerging challenges. By continuously monitoring water quality, maintaining sanitary distribution systems, and incorporating water-based supplements and medications, producers can ensure their birds thrive in ever-changing conditions.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Now is the time to elevate your water management practices—evaluate your water lines, invest in proper sanitation protocols, and adopt flexible supplementation strategies. In doing so, you will unlock the full potential of your birds and set the stage for more resilient, productive, and profitable poultry operations. For more information on nutrient supplementation through drinking water, please contact your expert Biochem representative.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"_uid":"f789e379-1cfd-4b6e-aed3-898e6ae835dd","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"c64e50ca-89a9-4021-8c4c-4c6ac049287c","title":"Water: The Key to Poultry Success","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/2541x1588/b66dbbcd89/the-irreplaceable-nutrient.jpeg","og_title":"Water: The Key to Poultry Success","description":"Water is essential for poultry health. Learn how to optimize water management, improve water quality, and leverage water-based supplementation to enhance bird performance and resilience.","twitter_image":"https://a.storyblok.com/f/190033/2541x1588/b66dbbcd89/the-irreplaceable-nutrient.jpeg","twitter_title":"Water: The Key to Poultry Success","og_description":"Water is essential for poultry health. Learn how to optimize water management, improve water quality, and leverage water-based supplementation to enhance bird performance and resilience.","twitter_description":"Water is essential for poultry health. Learn how to optimize water management, improve water quality, and leverage water-based supplementation to enhance bird performance and resilience."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Water, often overlooked, is a critical nutrient for poultry health and performance. Discover how optimizing water management and supplementation can elevate your bird’s well-being and productivity.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"Search_Tags":[],"Published_on":"2025-01-29 00:00","canonical_link":""},"slug":"the-irreplaceable-nutrient","full_slug":"news/articles/the-irreplaceable-nutrient","sort_by_date":null,"position":-80,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"3e6fe123-0269-4f25-9b96-868b961c3106","first_published_at":"2025-01-29T07:09:13.535Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/the-irreplaceable-nutrient","translated_slugs":[{"path":"news/articles/der-unersetzbare-naehrstoff","name":"Der unersetzbare Nährstoff","lang":"de","published":true},{"path":"news/articles/el-nutriente-irremplazable","name":"El nutriente irremplazable","lang":"es","published":true},{"path":"news/articles/o-nutriente-insubstituivel","name":"O nutriente insubstituível","lang":"pt-br","published":true}]},{"name":"Battling Mycotoxins: Unlocking Dairy Performance with B.I.O.Tox® Activ8","created_at":"2025-01-27T08:14:23.619Z","published_at":"2025-01-29T07:09:13.871Z","updated_at":"2025-01-29T07:09:13.951Z","id":615247945,"uuid":"90300bbf-989a-46e7-a784-1c40fc5f9c0e","content":{"Tags":[{"_uid":"c0797583-4d11-4153-8683-05e7d460dd27","Products":["e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","45bf1a90-a3c2-46f4-9a41-e8963e411941","14611b48-2ed1-414d-a2f3-4076014a0be0","aacc42ff-bd44-41b6-a7ca-dc3e5eba3fc5"],"component":"Tags","Animal_Species":["dcd74202-ba01-4f86-bd3f-f333607f395d","888ff53a-18a3-46b2-8333-ff560e35e5a1","fd1eeff1-3fec-434c-8cbc-39e38f966007","55d3b968-2ba6-474c-8926-7cf0e779b6e0"],"Feed_Solutions":["6b994c69-a560-4fc5-9942-3a00876716f2","abc9dcbc-1d46-4635-b3a9-26b833e011c1","0b70fc3f-fc3f-4201-84a5-be656f27c716","86957ee5-17c1-4614-b390-4ff76652d072","00925c7f-584a-4ca8-9180-967d87cf7261","f337bfba-c22d-4500-aea9-71cd3355246c"]}],"_uid":"8be4491e-5c9c-4ee5-80a9-c981ac6b2ae5","Image":{"id":20181325,"alt":"Battling Mycotoxins - Unlocking Dairy Performance with BIOTox® Activ8","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/8256x5504/cc698f6405/battling-mycotoxins-unlocking-dairy-performance-with-biotox-activ8.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"Battling Mycotoxins - Unlocking Dairy Performance with BIOTox® Activ8","title":"","source":"","copyright":""},"is_external_url":false},"Title":"Battling Mycotoxins: Unlocking Dairy Performance with B.I.O.Tox® Activ8","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":null},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"Mycotoxins are naturally occurring toxic secondary metabolites produced by fungi (molds) that can have a wide range of adverse effects, including liver and kidney toxicity, central nervous system effects, and estrogenic effects, to name just a few. Mycotoxins can contaminate a wide range of feed raw materials, compromising animal welfare, reducing animal performance, and affecting the sustainability and profitability of the entire value chain. The industry-important mycotoxins include aflatoxins, zearalenone, trichothecenes, fumonisins, ochratoxin A, and the ergot alkaloids.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Hidden Threats in Silage: Unveiling Mycotoxin Contamination","type":"text"}]},{"type":"paragraph","content":[{"text":"Mycotoxins occur in a range of livestock feeds, including concentrates, forages, hay, and silage. A survey of the global occurrence of mycotoxins found that 81 % of feed samples collected in the Americas, Europe, and Asia were positive for at least one mycotoxin.","type":"text"}]},{"type":"paragraph","content":[{"text":"A review of the literature shows that the contribution of silage, a major component of the dairy cow diet, to the total amount of mycotoxins ingested by cows can be significant. Indeed, silage was responsible for approximately 3 times more mycotoxin ingestion by dairy cows than other feed ingredients in a study of ensiled forages on 24 farms in the Netherlands.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"DON in Dairy: The Silent Saboteur Affecting Herd Health","type":"text"}]},{"type":"paragraph","content":[{"text":"Deoxynivalenol (DON) is a Fusarium produced mycotoxin that is commonly detected in feed. It is also called vomitoxin as it is associated with vomiting in swine and dogs. Among the livestock species, ruminants appear to be less sensitive to the effects of DON because of ruminal microbial degradation.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"However, additional metabolic burdens on ruminal microbes like concentrate-rich diets, faster rumen turnover rates, reduced pH, or high dietary DON levels, may restrict the ruminal detoxification capacity in high-yielding dairy cows. Under these conditions, DON exposure may cause problems comparable to those seen in monogastric animals.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The influence of (DON) on health and performance parameters of dairy cows has been widely reported. In short, DON shifts rumen microbial composition, alters rumen metabolism of unsaturated fatty acids and amino acids, and increases the risk of oxidative stress, inflammation, and reduced immune responses in dairy cows, leading to a wide range of symptoms such as decreased milk yield, altered milk quality, or an increase of metabolic and infectious diseases (Figure 1).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181781,"alt":"Figure 1: The effects of DON exposure to the health and productivity of dairy cows","src":"https://a.storyblok.com/f/190033/2880x1486/08f6b95543/figure-1-the-effects-of-don-exposure-to-the-health-and-productivity-of-dairy-cows.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: The effects of DON exposure to the health and productivity of dairy cows","title":"","source":"","copyright":""}}},{"text":"Figure 1: The effects of DON exposure to the health and productivity of dairy cows.","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"A survey of feed samples showed that DON is a common threat to livestock with a prevalence of 59 %. Another survey on the presence of mycotoxins in ensiled feed in the Netherlands found maize and wheat silage to be the main sources of DON in dairy cattle diets, and in Poland a multi-year mycotoxin survey found DON in 86 % of 143 maize silage samples.","type":"text"}]},{"type":"paragraph","content":[{"text":"These studies show, among other things, that DON is one of the most frequently detected mycotoxins in both feed and silage. As such, strategies aimed at preventing increased absorption of DON are essential for animal health and operational efficiency.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Comprehensive Mycotoxin Management: Beyond Simple Solutions","type":"text"}]},{"type":"paragraph","content":[{"text":"Comprehensive mycotoxin management is needed for effective mycotoxin control. This involves agricultural measures that should be considered before, during, and after the harvest. Toxin binders are another part of a complete toxin management strategy. Toxin binders are feed additives that can help to significantly reduce the bioavailability of mycotoxins. The","type":"text"},{"text":"y","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":" work by irreversibly binding mycotoxins, allowing for excretion in the feces. Although the concept is simple, in practice, this becomes a bit more complex.","type":"text"}]},{"type":"paragraph","content":[{"text":"For one, the different mycotoxins vary considerably in their physical and chemical properties and a good binder surface must meet these criteria to be as effective as possible. Moreover, the binder must retain these properties under the widely varying pH changes along the gastrointestinal tract, which also can influence the surface structure of the toxin binder. In essence, the goal is a binding component that stably binds all relevant mycotoxins in the intestinal tract at all pH levels.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Field Trial Success Story: B.I.O.Tox® Activ8 Boosts Dairy Performance","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The effectiveness of adding a toxin binder to the TMR was tested in a field trial on a German dairy farm with approximately 1,180 lactating cows. Farm production data showed a clear negative tendency from spring onwards, reaching a low point in June. Mycotoxins had been detected in the milk and in the TMR. Therefore, a toxin binder (","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"link","attrs":{"href":"/products/biotox-activ8","uuid":"e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":") was added to the diet of lactating cows for a period of two months, during which milk mycotoxin levels, performance, and health parameters were monitored.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The trial was conducted in an on-off design from 8 July to 10 September. Lactating cows were fed diets corresponding to their stage of lactation (start or high yield) with ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" (20 g/head/day in the start group and 25 g/head/day in the high yield group) added as a premix to the TMR.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"The TMR was analyzed for mycotoxins before the start of the study and at the end of the study. The test revealed the presence of DON and zearalenone (ZEA), indicating a continuous, natural contamination of these two mycotoxins during the trial period (Figure 2A, B).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181779,"alt":"Figure 2: DON and ZEA contamination levels in the TMR before trial start and at the end of the trial","src":"https://a.storyblok.com/f/190033/2880x1600/b06c4ab906/figure-2-don-and-zea-contamination-levels-in-the-tmr-before-trial-start-and-at-the-end-of-the-trial.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: DON and ZEA contamination levels in the TMR before trial start and at the end of the trial","title":"","source":"","copyright":""}}},{"text":"Figure 2: DON and ZEA contamination levels in the TMR before trial start and at the end of the trial.","type":"text","marks":[{"type":"italic"},{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Moreover, DON was noted in milk samples at a level of 70 µg/L before the start of the trial. The addition of ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"link","attrs":{"href":"/products/biotox-activ8","uuid":"e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" to the diet resulted in a stark reduction in DON milk levels at the end of the trial (70 µg/L to 17.3 µg/L; Figure 3). The clear reduction of DON-derivates in the milk in the face of constant mycotoxin contamination in the TMR underscores the efficiency of ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" in reducing DON’s bioavailability.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181780,"alt":"Figure 3: DON contamination levels in the milk before trial start and at the end of the trial","src":"https://a.storyblok.com/f/190033/2880x1600/8ac276c8a3/figure-3-don-contamination-levels-in-the-milk-before-trial-start-and-at-the-end-of-the-trial.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 3: DON contamination levels in the milk before trial start and at the end of the trial","title":"","source":"","copyright":""}}},{"text":"Figure 3: DON contamination levels in the milk before trial start and at the end of the trial.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Compared to the previous nine-month average, the June (pre-trial) milk yield was down 12.9 % (Figure 4A). In addition, milk fat in tank milk had decreased significantly in June compared to the previous month (Figure 4B). By the end of the trial, milk yield had increased by 8 % compared to June and milk fat in tank milk had increased dramatically to levels greater than before the trial (Figure 4B).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20181778,"alt":"Figure 4: Official testing milking averages before and during the trial (A)","src":"https://a.storyblok.com/f/190033/2880x1600/58bad1ad4a/figure-4-official-testing-milking-averages-before-and-during-the-trial-a.jpg","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 4: Official testing milking averages before and during the trial (A)","title":"","source":"","copyright":""}}},{"text":"Figure 4: Official testing milking averages before and during the trial (A), Percentage milk fat in tank milk for the two months preceding the trial and during the trial (B).","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"In addition, compared to the preceding nine-month average, the SSC had increased from 328 (x 1000/mL) to 475 (x 1000/mL) in June. After the addition of ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" during the trial period, the SCC was reduced to near baseline levels of 390 (x 1000/mL) in September (data not shown). Blood serum measurements of liver enzymes showed improved liver health at the end of the trial (data not shown).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"B.I.O.Tox® Activ8: Your Holistic Solution for Mycotoxin Control","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"link","attrs":{"href":"/products/biotox-activ8","uuid":"e2b57bfe-8a38-4f40-bb3b-c06f7be91dd8","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"’s supreme binding capabilities make it highly effective against all major mycotoxins, including aflatoxins, ochratoxins, zearalenone, T-2/HT2-toxin, DON, and fumonisins. However, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8 ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"is more than just a mycotoxin binder; it also contains natural detoxifiers that support the liver’s antioxidative and detoxifying processes. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8 ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"helps to prevent or counteract the damage caused by mycotoxins and improves overall performance.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"B.I.O.Tox®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" ","type":"text","marks":[{"type":"bold"},{"type":"superscript"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is a reliable and scientifically supported solution to mycotoxin contamination in animal feed. Its combination of supreme binding capabilities and natural detoxifiers makes it a holistic solution for improving animal health and performance as well as protecting human safety.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is your solution for fast and efficient mycotoxin control!","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"_uid":"f789e379-1cfd-4b6e-aed3-898e6ae835dd","noSpace":true,"component":"General_Text_Section"}],"no_index":false,"component":"article","meta_tags":{"_uid":"c64e50ca-89a9-4021-8c4c-4c6ac049287c","title":"B.I.O.Tox® Activ8: Combat Mycotoxins to Boost Dairy Cow Health & Yield","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/8256x5504/cc698f6405/battling-mycotoxins-unlocking-dairy-performance-with-biotox-activ8.jpeg","og_title":"B.I.O.Tox® Activ8: Combat Mycotoxins to Boost Dairy Cow Health & Yield","description":"Discover how B.I.O.Tox® Activ8 combats mycotoxins like DON in dairy feed, enhancing cow health and boosting milk yield. 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Discover how ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"B.I.O.Tox® Activ8","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", a powerful toxin binder, effectively reduces mycotoxin bioavailability, boosts milk production, and enhances overall herd health. 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","type":"text"}]},{"type":"paragraph","content":[{"text":"The essential nature of trace minerals in the diet is well known and that this need increases with production or stress is also well described. Trace minerals are divided between inorganic and organic forms. While inorganic trace minerals are readily available and inexpensive, organic trace minerals reign supreme in absorption, effectiveness, and overall benefits. Typically, organic trace minerals are complexed with small peptides or amino acids to enhance their uptake.","type":"text"}]},{"type":"paragraph","content":[{"text":"Now, there’s a new player in town: introducing ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"BetaTrace","type":"text","marks":[{"type":"link","attrs":{"href":"/products/betatrace-iron","uuid":"f5274c6a-af67-43df-825f-3edbe545141f","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":", a unique, patent-pending organic trace mineral source where the mineral is bound to betaine—a functional binding partner. 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Betaine is an amazing ingredient that provides excellent methyl group donor capability, which is essential for protein and lipid metabolism. Both high-yielding and young animals have particularly high requirements here, and ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"BetaTrace","type":"text","marks":[{"type":"link","attrs":{"href":"/products/betatrace-zinc","uuid":"984342f5-f5a8-4a99-9ad8-7f3662405f4d","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"®","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is the perfect solution! This incredible 2-in-1 invention supports performance and health even more intensively, making it a must-have for any animal nutrition program.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"Both betaine and organic trace minerals play significant roles in various physiological metabolic processes. Organic minerals serve as essential components and cofactors for numerous enzymes, vitamins, and hormones (Figure 1). Meanwhile, the metabolic powerhouse betaine provides excellent methyl group donor capabilities. This is especially important for protein and lipid metabolism (Figure 2).","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20180738,"alt":"Figure 1 - The many essential functions of trace minerals","src":"https://a.storyblok.com/f/190033/2881x1744/f2052091e2/figure-1-the-many-essential-functions-of-trace-minerals.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1 - The many essential functions of trace minerals","title":"","source":"","copyright":""}}},{"text":"Figure 1: The many essential functions of trace minerals.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":20383537,"alt":"Figure 2: The importance of betaine in methylation. 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","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"BetaTrace","type":"text","marks":[{"type":"link","attrs":{"href":"/products/betatrace-manganese","uuid":"b178460e-bb50-4d76-88b2-021d0949dfa6","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"® ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"assists in the metabolism of carbohydrates and cholesterol. In addition, ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"BetaTrace® ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"helps to improve the free passage of nutrients into cells and to regulate glucose levels and fatty acid breakdown. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"BetaTrace® ","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"provides the methyl groups needed for creatine and carnitine synthesis—important for energy conservation and fatty acid metabolism.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"The BetaTrace® Effect.","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]},{"type":"paragraph","content":[{"text":"BetaTrace® Zn","type":"text","marks":[{"type":"link","attrs":{"href":"/products/betatrace-zinc","uuid":"984342f5-f5a8-4a99-9ad8-7f3662405f4d","anchor":null,"custom":{},"target":"_self","linktype":"story"}},{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" was tested in a 35-day feeding trial for its effects on production parameters at Poznań University of Life Sciences. 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","type":"text"}]},{"type":"paragraph","content":[{"text":"The health of young calves has a significant impact on their entire lifespan, affecting growth rates, reproductive efficiency and even future milk production. In fact, calves are more susceptible to mortality during the first three weeks of life than during the rest of their rearing period, which makes this period extremely important, economically. Numerous factors, including animal, environmental and management practices, contribute to calf health and disease (Figure 1).","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":17407767,"alt":"Figure 1: The many factors associated with the health and morbidity of calves","src":"https://a.storyblok.com/f/190033/3840x2160/92e5906256/figure-1-the-many-factors-associated-with-the-health-and-morbidity-of-calves.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: The many factors associated with the health and morbidity of calves","title":"","source":"","copyright":""}}},{"text":"Figure 1: The many factors associated with the health and morbidity of calves.","type":"text","marks":[{"type":"italic"}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"The Critical First Weeks.","type":"text"}]},{"type":"paragraph","content":[{"text":"Neonatal disease, especially diarrhea, has a significant impact on growth during the rearing period, long-term future performance and loss of genetic potential for future herd improvement. To effectively control calf diarrhea, a proactive approach is essential.","type":"text"}]},{"type":"paragraph","content":[{"text":"Implementing strong biosecurity measures, including cow vaccination programs and maintaining a clean environment, is critical. Providing newborn calves with an adequate amount of high-quality colostrum in a timely manner is another cornerstone of calf health. By focusing on these preventive strategies, farmers can build calf immunity and reduce disease incidence. However, despite significant advances in the understanding of neonatal diarrhea, it remains one of the leading causes of death in calves.","type":"text"}]},{"type":"paragraph","content":[{"text":"There are numerous infectious and non-infectious agents associated with calf diarrhea—it is not a single disease. Infectious causes include bacteria such as ","type":"text"},{"text":"E. coli","type":"text","marks":[{"type":"italic"}]},{"text":", ","type":"text"},{"text":"Salmonella","type":"text","marks":[{"type":"italic"}]},{"text":", and ","type":"text"},{"text":"Clostridium perfringens","type":"text","marks":[{"type":"italic"}]},{"text":"; viruses such as rotavirus and coronavirus; and protozoa such as cryptosporidia and coccidia (Figure 2).","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":17407770,"alt":"Figure 2: The most common bacteria responsible for calf diarrhea","src":"https://a.storyblok.com/f/190033/3840x2160/ff06f89f31/figure-2-the-most-common-bacteria-responsible-for-calf-diarrhea.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: The most common bacteria responsible for calf diarrhea","title":"","source":"","copyright":""}}},{"text":"Figure 2: The most common bacteria responsible for calf diarrhea are E. Coli, Salmonella, and Clostridium perfringens. The viruses causing diarrhea in the calf are Rotavirus, Coronavirus, Bovine Viral Diarrhea Virus, and Bovine Herpesvirus 1. A few protozoan species like Cryptosporidia and coccidiosis are responsible for calf diarrhea.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Some pathogens, like ","type":"text"},{"text":"E. coli","type":"text","marks":[{"type":"italic"}]},{"text":", produce toxins that stimulate an enzyme cascade and a large release of chloride ions into the intestinal lumen. Sodium passively follows to help maintain electron neutrality, and, as the osmotic pressure in the intestine increases, so does water. This is the pathogenesis of secretory diarrhea. Other pathogens—typically rotavirus and coronaviruses—cause osmotic diarrhea. These pathogens attack the intestinal villi causing villus atrophy, reducing the intestine’s digestive and absorptive capacity. Unabsorbed nutrients then remain in the intestine causing an increased osmotic pressure and water secretion into the intestinal tract (Figure 3).","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":17407769,"alt":"Figure 3: The mechanisms of secretory and osmotic diarrhea","src":"https://a.storyblok.com/f/190033/2880x1486/31fcd27d51/figure-3-the-mechanisms-of-secretory-and-osmotic-diarrhea.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 3: The mechanisms of secretory and osmotic diarrhea","title":"","source":"","copyright":""}}},{"text":"Figure 3: The mechanisms of secretory and osmotic diarrhea. In both cases, the result is a net movement of water into the intestine, resulting in diarrhea.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"However, regardless of the pathogen or mechanism involved, diarrhea increases the loss of electrolytes and water in the feces and often decreases milk intake. The result is dehydration, potentially causing severe metabolic acidosis, electrolyte abnormalities, and negative energy balance. Even when calves recover from these infections, they may never perform as well as unaffected animals.","type":"text"}]},{"type":"paragraph","content":[{"text":"A study of the long-term growth effects of cryptosporidiosis found that calves diagnosed with severe cryptosporidiosis had significantly reduced weight gain at 6 months compared to calves with only few clinical signs of infection. This underscores the negative long-term effects of this pathogen on weight gain and production efficiency.","type":"text"}]},{"type":"paragraph","content":[{"text":"It is critical for every farm to have an effective strategy to prevent and treat calf diarrhea, as quick action should be taken when diarrhea occurs. The priority is to minimize the calf’s fluid loss to prevent dehydration and reduce the risk of metabolic acidosis. Stabilizing the intestinal microbiota and promoting the regeneration of intestinal villi are additional key points to address in cases of calf diarrhea.","type":"text"}]},{"type":"paragraph","content":[{"text":"There are two main strategies for treating diarrhea. One is the compensation of existing fluid loss with products containing electrolytes like ","type":"text"},{"text":"Prolyt Pack® Extra","type":"text","marks":[{"type":"bold"}]},{"text":". The second is the reduction of fluid loss itself by using water-attracting products. This strategy works to decrease fluid loss, retaining it in the body.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"DiaReset: Part of an Effective Strategy.","type":"text"}]},{"type":"paragraph","content":[{"text":"One such strategy is a dietary feed supplement, ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"link","attrs":{"href":"https://app.storyblok.com/products/diareset","uuid":"f217d7d7-57d7-4368-a985-30edb8032827","anchor":null,"custom":"[object Object]","target":"_self","linktype":"story"}},{"type":"bold"}]},{"text":", designed to be given to calves during a case of diarrhea to ease the intensity, reduce fluid loss, help restore gut integrity, and minimize performance losses. This unique product contains guar gum and provides fast and effective support when needed.","type":"text"}]},{"type":"paragraph","content":[{"text":"Guar gum is composed primarily of galactomannan, a polysaccharide that forms a gel when in contact with water. Guar gum increases viscosity and fecal volume, prolongs passage rate, and reduces defecation frequency. Additionally, it is almost 100% fermentable for a positive effect on microbiota growth.","type":"text"}]},{"type":"paragraph","content":[{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":" combines two natural probiotic strains that suppress the growth of non-beneficial bacteria while promoting the growth of lactic acid producing bacteria, participate in beneficial immune modulation, and increase nutrient digestibility through the production of digestive enzymes. Together, these powerful probiotics stabilize the gut microbiota.","type":"text"}]},{"type":"paragraph","content":[{"text":"Prebiotic yeast cell walls from hydrolyzed yeast complete the synbiotic component of ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":". This prebiotic can bind gram negative pathogens such as ","type":"text"},{"text":"E. coli","type":"text","marks":[{"type":"italic"}]},{"text":" and ","type":"text"},{"text":"Salmonella","type":"text","marks":[{"type":"italic"}]},{"text":" and help to prevent these pathogens from adhering to the intestinal wall as well as modulating and stimulating the immune system. Hydrolyzed yeast also provides functional amino and nucleic acids to support intestinal development and beneficial intestinal microbiota.","type":"text"}]},{"type":"paragraph","content":[{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":" also contains a source of saponins—compounds that are part of the defense mechanism of some plants. These saponins have been shown to have antiprotozoal, antibacterial, anti-inflammatory, and immunostimulatory properties. Their effects on protozoa are particularly important as cryptosporidia is a top cause of calf diarrhea. By complexing with a cholesterol moiety of protozoan cell membranes, saponins can induce pore formation, cell lysis, and death.","type":"text"}]},{"type":"paragraph","content":[{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":" is supplemented with vitamins to support immune function and a highly bioavailable source of zinc. Zinc has many roles, including antioxidant functions, immune support, and tissue repair and healing. This includes the gut, where zinc stimulates cell proliferation, helps restore the mucosal lining, and improves barrier function.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Field-Proven Results.","type":"text"}]},{"type":"paragraph","content":[{"text":"A 12-week field trial was conducted to evaluate the effect of ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"link","attrs":{"href":"https://app.storyblok.com/products/diareset","uuid":"f217d7d7-57d7-4368-a985-30edb8032827","anchor":null,"custom":"[object Object]","target":"_self","linktype":"story"}},{"type":"bold"}]},{"text":" ","type":"text","marks":[{"type":"link","attrs":{"href":"https://app.storyblok.com/products/diareset","uuid":"f217d7d7-57d7-4368-a985-30edb8032827","anchor":null,"custom":"[object Object]","target":"_self","linktype":"story"}}]},{"text":"on the regeneration and performance of calves with diarrhea. Calves (n=23) less than two weeks old that were showing signs of diarrhea were assigned to the treatment group. The control group (n=22) consisted of healthy calves that had been matched in age, sex, and dam parity to the treatment group. Calves in the treatment group received 100 g ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":" twice daily until no signs of diarrhea were visible. The control group received no dietary feed supplement.","type":"text"}]},{"type":"paragraph","content":[{"text":"Fecal scoring was performed using the following scale: 1 = physiologically normal, 2 = pasty, 3 = thin feces but remaining on the bedding, 4 = very thin feces running through the bedding. In addition, health scoring was performed, and feed intake as well as body weight was recorded. On average, diarrhea occurred for the first time between day 9 and day 10.","type":"text"}]},{"type":"paragraph","content":[{"text":"In the trial, 81% of calves had normal fecal consistency (Grade 1) on day 3 after supplementation with ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":", and 91% of calves had normal stool consistency after 4 days, with a corresponding improvement in health score (Figure 4).","type":"text"}]},{"type":"paragraph","content":[{"text":"Although the daily weight gain of diarrheic calves often remains low, mainly due to damaged intestinal epithelium and reduced feed intake, calves supplemented with ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":" showed significantly higher weight gains during the first 28 days of life. Thus, the high acceptance of ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":" could help avoid the reduced feed intake in these cases.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":17407768,"alt":"Figure 4: Average fecal and health score of diarrhea-affected calves supplemented with DiaReset","src":"https://a.storyblok.com/f/190033/2880x1600/f39f6d0f2c/figure-4-average-fecal-and-health-score-of-diarrhea-affected-calves-supplemented-with-diareset.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 4: Average fecal and health score of diarrhea-affected calves supplemented with DiaReset","title":"","source":"","copyright":""}}},{"text":"Figure 4: Average fecal and health score of diarrhea-affected calves supplemented with ","type":"text","marks":[{"type":"italic"}]},{"text":"DiaReset","type":"text","marks":[{"type":"bold"},{"type":"italic"}]},{"text":". On day 3, 81% of calves had normal fecal consistency (Grade 1) after supplementation with ","type":"text","marks":[{"type":"italic"}]},{"text":"DiaReset","type":"text","marks":[{"type":"bold"},{"type":"italic"}]},{"text":", and 91% of calves had normal stool consistency after 4 days, with a corresponding improvement in health score.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"Whichever system is chosen, a quick response is needed. ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"bold"}]},{"text":"’s unique combination of ingredients can either help prevent or quickly reduce water loss in calves with diarrhea and support rapid regeneration for a quick return to previous performance levels.","type":"text"}]},{"type":"paragraph","content":[{"text":"Stay one step ahead with ","type":"text"},{"text":"DiaReset","type":"text","marks":[{"type":"link","attrs":{"href":"https://app.storyblok.com/products/diareset","uuid":"f217d7d7-57d7-4368-a985-30edb8032827","anchor":null,"custom":"[object Object]","target":"_self","linktype":"story"}},{"type":"bold"}]},{"text":".","type":"text"}]}]},"_uid":"f3547ba8-42f9-4c3e-859b-34dde1c0226d","noSpace":true,"_editable":"","component":"General_Text_Section"}],"no_index":false,"_editable":"","component":"article","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"Combatting Calf Diarrhea: A Cornerstone of Dairy Success - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/7008x4672/530c63967f/combatting-calf-diarrhea-a-cornerstone-of-dairy-success.jpeg","og_title":"Combatting Calf Diarrhea: A Cornerstone of Dairy Success - Biochem","description":"The first few weeks of a calf’s life are critical, with health issues like diarrhea posing serious risks to their long-term growth and productivity. ","twitter_image":"https://a.storyblok.com/f/190033/7008x4672/530c63967f/combatting-calf-diarrhea-a-cornerstone-of-dairy-success.jpeg","twitter_title":"Combatting Calf Diarrhea: A Cornerstone of Dairy Success - Biochem","og_description":"The first few weeks of a calf’s life are critical, with health issues like diarrhea posing serious risks to their long-term growth and productivity. ","twitter_description":"The first few weeks of a calf’s life are critical, with health issues like diarrhea posing serious risks to their long-term growth and productivity. "},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The first few weeks of a calf’s life are critical, with health issues like diarrhea posing serious risks to their long-term growth and productivity. ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"DiaReset","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":" is a powerful feed supplement designed to combat the impact of diarrhea, helping calves recover quickly and maintain their growth trajectory. Discover how ","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]},{"text":"DiaReset","type":"text","marks":[{"type":"bold"},{"type":"textStyle","attrs":{"color":""}}]},{"text":"’s unique combination of ingredients can support gut health, reduce fluid loss, and promote rapid recovery in your calves, ensuring they reach their full potential. Learn more about this essential tool for calf health!","type":"text","marks":[{"type":"textStyle","attrs":{"color":""}}]}]}]},"Search_Tags":[],"Published_on":"2024-09-26 00:00","canonical_link":""},"slug":"combatting-calf-diarrhea-a-cornerstone-of-dairy-success","full_slug":"news/articles/combatting-calf-diarrhea-a-cornerstone-of-dairy-success","sort_by_date":null,"position":-50,"tag_list":[],"is_startpage":false,"parent_id":315439458,"meta_data":null,"group_id":"2a49dd58-7114-4085-a1cc-9f0b1380305d","first_published_at":"2023-10-18T10:05:29.375Z","release_id":null,"lang":"default","path":null,"alternates":[],"default_full_slug":"news/articles/combatting-calf-diarrhea-a-cornerstone-of-dairy-success","translated_slugs":[{"path":"news/articles/behandlung-von-kaelberdurchfall-ein-wichtiger-faktor-fuer-den-erfolg-in-der-milchviehhaltung","name":"Behandlung von Kälberdurchfall: Ein wichtiger Faktor für den Erfolg in der Milchviehhaltung.","lang":"de","published":true},{"path":"news/articles/combatir-la-diarrea-de-los-terneros-una-piedra-angular-del-exito-lechero","name":"Combatir la diarrea de los terneros: Una piedra angular del éxito lechero.","lang":"es","published":true},{"path":"news/articles/o-pilar-para-sucesso-do-setor-de-laticinios","name":"O pilar para sucesso do setor de laticínios.","lang":"pt-br","published":true}]},{"name":"Protecting Your Pet’s Powerhouse Organs.","created_at":"2024-09-23T07:04:11.218Z","published_at":"2025-01-29T08:05:18.515Z","updated_at":"2025-01-29T08:05:18.557Z","id":552014937,"uuid":"6fbe0949-7c33-4870-ab8b-d80af2875b22","content":{"Tags":[{"_uid":"5d463760-af21-4bf4-af72-836894083749","Products":["43744eb8-465d-40d4-bf7e-8ee717f3abf6"],"_editable":"","component":"Tags","Animal_Species":["68e0ff4d-df74-4e39-88f4-db24d095692d"],"Feed_Solutions":["abc9dcbc-1d46-4635-b3a9-26b833e011c1","fcc755b6-e358-48cd-aa0c-0ae722252c04","00925c7f-584a-4ca8-9180-967d87cf7261","f337bfba-c22d-4500-aea9-71cd3355246c"]}],"_uid":"6d3f070a-00ba-4f74-b146-ab1116f4f603","Image":{"id":17403293,"alt":"Protecting Your Pet’s Powerhouse Organs.","name":"","focus":"","title":"","source":"","filename":"https://a.storyblok.com/f/190033/4792x3195/a91a9e9876/protecting-your-pet-s-powerhouse-organs.jpeg","copyright":"","fieldtype":"asset","meta_data":{"alt":"Protecting Your Pet’s Powerhouse Organs.","title":"","source":"","copyright":""},"is_external_url":false},"Title":"Protecting Your Pet’s Powerhouse Organs.","Author":"Biochem Team","Sections":[{"Text":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"The Newsletter Out Loud: Listen to this article.","type":"text","marks":[{"type":"bold"}]}]},{"type":"code_block","attrs":{"class":"language-html"},"content":[{"text":"

","type":"text"}]},{"type":"paragraph","content":[{"text":"Few organs in the body have such important functions as the kidneys and liver, yet they are often overlooked. Both are responsible for important metabolic processes necessary to sustain life, as well as the removal of toxins. The liver has many functions. It removes toxins from the blood, helps break down drugs, participates in energy metabolism, stores vitamins, and glycogen, aids in digestion, and produces proteins needed for blood clotting.","type":"text"}]},{"type":"paragraph","content":[{"text":"The kidney is an amazing multi-purpose organ. It is designed to do much more than produce urine and remove metabolic waste. It also manages hydration, blood pressure, red blood cell production, blood pH balance, calcium, phosphorus, and potassium balance, protein conservation, and more (Figure 1).","type":"text"}]},{"type":"paragraph","content":[{"text":"Because the kidneys and liver are multi-functional organs, problems with these organs can have different symptoms depending on the function affected and often affect other systems in the body. For example, a problem affecting the liver’s ability to make clotting factors may show up as bruising or uncontrolled bleeding.","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":17403361,"alt":"Figure 1: The many functions of the liver and the kidney","src":"https://a.storyblok.com/f/190033/2372x1266/1d9ece4649/figure-1-the-many-functions-of-the-liver-and-the-kidney.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 1: The many functions of the liver and the kidney","title":"","source":"","copyright":""}}},{"text":"Figure 1: The many functions of the liver and the kidney.","type":"text","marks":[{"type":"italic"}]}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Common Challenges: Kidney and Liver Problems in Pets.","type":"text"}]},{"type":"paragraph","content":[{"text":"There can be many causes for problems in an organ system. These problems can come from the organ itself (primary) or from another area affecting the organ (secondary); they can be infectious (viral or bacterial) or non-infectious (such as cancer or toxins); and they can be born with the problem (congenital) or develop during the animal’s life (acquired).","type":"text"}]},{"type":"paragraph","content":[{"text":"The most common health problem related to the kidney is chronic kidney disease (CKD). Essentially, this is when there is not enough working kidney tissue to maintain its normal waste-filtering function. Chronic kidney disease is a problem for both dogs and cats, although it is more common in cats. Among dogs 7–11 years of age, 8–12 % have signs of CKD, with the percentage increasing with age. In one study of cats, the incidence of CKD was approximately 40 % in cats less than 15 years of age and 80 % in cats 15 years of age or older.","type":"text"}]},{"type":"paragraph","content":[{"text":"Dogs and cats overlap when it comes to kidney problems, but not with the liver. In dogs, the most common liver problem is chronic hepatitis. In most cases, the cause is unknown, but this disease may have a viral component such as canine infectious hepatitis. Dogs with chronic hepatitis often present with nonspecific signs like vomiting or poor appetite and not necessarily with signs of a liver problem (Figure 2).","type":"text"}]},{"type":"paragraph","content":[{"type":"image","attrs":{"id":17403369,"alt":"Figure 2: The signs of kidney and liver problems","src":"https://a.storyblok.com/f/190033/2372x1266/b9e2358c56/figure-2-the-signs-of-kidney-and-liver-problems.png","title":"","source":"","copyright":"","meta_data":{"alt":"Figure 2: The signs of kidney and liver problems","title":"","source":"","copyright":""}}},{"text":"Figure 2: The signs of kidney and liver problems.","type":"text","marks":[{"type":"italic"}]}]},{"type":"paragraph","content":[{"text":"In cats, feline hepatic lipidosis (fatty liver) is the most common potentially fatal feline liver disease. The cat has evolved to eat several small meals throughout the day, keeping lean with minimal fat storage. This all changed when cats were domesticated—the modern domestic cat has many opportunities to become overweight.","type":"text"}]},{"type":"paragraph","content":[{"text":"While this may not be a problem on a day-to-day basis, a reduction in food intake can trigger the development of fatty liver. In fact, fatty liver can develop in as little as two weeks with a 50–75 % reduction in food intake. During this period of starvation, fat stores are mobilized to the liver for processing into lipoproteins. However, the cat’s liver cannot handle the large amount of fat; the liver becomes fatty and fails.","type":"text"}]},{"type":"paragraph","content":[{"text":"However, the most typical liver-related findings in dogs and cats are elevated liver enzymes. Elevated liver enzymes are common and often nonspecific. High liver enzyme values may indicate a specific liver disease, but in some cases, liver enzymes may be elevated due to problems elsewhere in the body or simply due to age.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"The Gut-Kidney-Liver Connection: A Delicate Balance.","type":"text"}]},{"type":"paragraph","content":[{"text":"A third organ system that is connected to both the kidneys and the liver is the intestinal tract. It has been reported that cats with CKD have altered microbiota profiles compared to healthy cats. In addition, this dysbiosis may result in the production of nitrogen-containing toxins that can damage intestinal epithelial tight junctions and reduce intestinal barrier function.","type":"text"}]},{"type":"paragraph","content":[{"text":"This can interfere with normal digestion and nutrient absorption, and it also can allow pathogenic bacteria and toxins to enter the body, with the liver being the first stop. One such group are the mycotoxins—harmful secondary metabolites produced by molds that can have devastating health effects. Aflatoxin B1, ochratoxin A, fumonisin B1, zearalenone, and deoxynivalenol are the most common mycotoxins found in food and feed for pets and livestock.","type":"text"}]},{"type":"paragraph","content":[{"text":"Not only do mycotoxins themselves damage the gut and reduce its barrier function, but aflatoxin and ochratoxin, in particular, are known to cause liver and kidney damage in animals. Dogs are more susceptible to aflatoxins, in part due to their relatively low activity of the liver enzyme glutathione S-transferase. Aflatoxin toxicosis can often be overlooked due to nonspecific clinical signs.","type":"text"}]},{"type":"heading","attrs":{"level":2},"content":[{"text":"Vital Organs, Vital Care.","type":"text"}]},{"type":"paragraph","content":[{"text":"HePaw Syn","type":"text","marks":[{"type":"link","attrs":{"href":"https://app.storyblok.com/products/hepaw-syn","uuid":"43744eb8-465d-40d4-bf7e-8ee717f3abf6","anchor":null,"custom":"[object Object]","target":"_self","linktype":"story"}},{"type":"bold"}]},{"text":" is a dietary feed supplement that is formulated for maximal pet health. It is a combination of beneficial ingredients such as betaine, a toxin binder, and pro- and prebiotics focusing on liver, kidney, and gut support. Together with highly bioavailable trace elements, vitamins, and natural phytoactive ingredients, ","type":"text"},{"text":"HePaw Syn","type":"text","marks":[{"type":"bold"}]},{"text":" is a complete formula for additional metabolic and antioxidative support.","type":"text"}]},{"type":"paragraph","content":[{"text":"Betaine is a powerful methyl group donor for methylation reactions, an essential biochemical process for all life. Research in cats with CKD shows that betaine supplementation improves body composition with benefits in lean body mass, likely due to improved energy utilization, indicating increased one-carbon metabolism. This may help combat the loss of body mass experienced by animals—especially cats—with CKD. In the liver, betaine participates in protein and lipid metabolism and increases antioxidant capacity, protecting against stress.","type":"text"}]},{"type":"paragraph","content":[{"text":"Betaine protects from osmotic stress. In the kidney, betaine preserves cell volume and function in the presence of the high osmolarity required for proper renal function. Blood levels of betaine decrease with CKD, but studies in mice show that oral supplementation with betaine significantly increased markers of improved renal function. Studies in cats with CKD show that betaine supplementation results in changes in blood markers associated with better kidney health. In dogs with early-stage kidney disease, betaine supplementation resulted in positive effects on blood and intestinal health markers.","type":"text"}]},{"type":"paragraph","content":[{"text":"As the gut is a gateway to the body, another feature of ","type":"text"},{"text":"HePaw Syn","type":"text","marks":[{"type":"bold"}]},{"text":" is its toxin binder. Mycotoxins can contaminate grains and grain by-products, which are widely used in commercial pet foods. Even with the high temperatures and pressure needed to make dry food, the mycotoxins remain unaffected and can make their way into the food. ","type":"text"},{"text":"HePaw Syn","type":"text","marks":[{"type":"bold"}]},{"text":" contains toxin binders that irreversibly bind these harmful toxins and may provide protection against mycotoxin exposure. Complementing the toxin binder are two probiotics—a live yeast probiotic and the microbial probiotic ","type":"text"},{"text":"Enterococcus faecium","type":"text","marks":[{"type":"italic"}]},{"text":". Additionally, ","type":"text"},{"text":"HePaw Syn","type":"text","marks":[{"type":"bold"}]},{"text":" contains a potent, primary cultured yeast prebiotic for effective gut microbiota support—a true synbiotic to support overall gut health and a balanced microbiota.","type":"text"}]},{"type":"paragraph","content":[{"text":"HePaw Syn","type":"text","marks":[{"type":"bold"}]},{"text":"’s unique formulation supports the function and health of vital organs like the liver, kidneys, intestine. It is perfect for supplementation when problems arise acutely, or it can be used for long-term support. ","type":"text"},{"text":"HePaw Syn","type":"text","marks":[{"type":"link","attrs":{"href":"https://app.storyblok.com/products/hepaw-syn","uuid":"43744eb8-465d-40d4-bf7e-8ee717f3abf6","anchor":null,"custom":"[object Object]","target":"_self","linktype":"story"}},{"type":"bold"}]},{"text":" is designed to keep pets healthy!","type":"text"}]}]},"_uid":"f3547ba8-42f9-4c3e-859b-34dde1c0226d","noSpace":true,"_editable":"","component":"General_Text_Section"}],"no_index":false,"_editable":"","component":"article","meta_tags":{"_uid":"acb34e7e-480f-4ed7-8f2d-b4bc341a7064","title":"Protecting Your Pet’s Powerhouse Organs - Biochem","plugin":"seo_metatags","og_image":"https://a.storyblok.com/f/190033/4792x3195/a91a9e9876/protecting-your-pet-s-powerhouse-organs.jpeg","og_title":"Protecting Your Pet’s Powerhouse Organs - Biochem","description":"Our pets rely on their kidneys, liver, and gut to maintain overall health, but these vital organs often face significant challenges.","twitter_image":"https://a.storyblok.com/f/190033/4792x3195/a91a9e9876/protecting-your-pet-s-powerhouse-organs.jpeg","twitter_title":"Protecting Your Pet’s Powerhouse Organs - Biochem","og_description":"Our pets rely on their kidneys, liver, and gut to maintain overall health, but these vital organs often face significant challenges.","twitter_description":"Our pets rely on their kidneys, liver, and gut to maintain overall health, but these vital organs often face significant challenges."},"Description":{"type":"doc","content":[{"type":"paragraph","content":[{"text":"Our pets rely on their kidneys, liver, and gut to maintain overall health, but these vital organs often face significant challenges. 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